Published in iScience
CD32 has raised conflicting results as a putative marker of the HIV-1 reservoir. We measured CD32 expression in tissues from viremic and virally suppressed humanized mice treated relatively early or late after HIV-1 infection with combined antiretroviral therapy. CD32 was expressed in a small fraction of the memory CD4+ T-cell subsets from differen...
Published in Proceedings on Privacy Enhancing Technologies
Existing anonymity systems sacrifice anonymity for efficient communication or vice-versa. Onion-routing achieves low latency, high bandwidth, and scalable anonymous communication, but is susceptible to traffic analysis attacks. Designs based on DC-Nets, on the other hand, protect the users against traffic analysis attacks, but sacrifice bandwidth. ...
Published in Scientific Reports
Several viruses of the corona family interact, via their spike (S) proteins, with human cellular receptors. Spike proteins of SARS-CoV-1 and SARS-CoV-2 virions, being structurally related but not identical, mediate attachment to the human angiotensin-converting enzyme 2 (hACE2) receptor in similar but non-identical ways. Molecular-level understandi...
Published in Scientific Reports
The spread of COVID-19 in healthcare settings is concerning, with healthcare workers representing a disproportionately high percentage of confirmed cases. Although SARS-CoV-2 virus has been found to persist on surfaces for a number of days, the extent and duration of fomites as a mode of transmission, particularly in healthcare settings, has not be...
Published in Scientific Reports
Lectins, carbohydrate-binding proteins, have been regarded as potential antiviral agents, as some can bind glycans on viral surface glycoproteins and inactivate their functions. However, clinical development of lectins has been stalled by the mitogenicity of many of these proteins, which is the ability to stimulate deleterious proliferation, especi...
Published in Scientific Reports
Foot-and-mouth disease (FMD) is one of the most contagious diseases of cloven-hoofed animals. Disinfectants are used to inactivate FMD virus (FMDV) in Japan. Reports that heat-denatured lysozyme inactivates bacteria as well as viruses, such as norovirus and hepatitis A virus, led us to determine its effects on FMDV. We show here that heat-denatured...
Published in Scientific Reports
Zika virus (ZIKV) has emerged as a serious health threat in the Americas and the Caribbean. ZIKV is transmitted by the bite of an infected mosquito, sexual contact, and blood transfusion. ZIKV can also be transmitted to the developing fetus in utero, in some cases resulting in spontaneous abortion, fetal brain abnormalities, and microcephaly. In ad...
Published in Nature Reviews Physics
Viruses are highly dynamic structures. Physics approaches are well suited to study the mechanisms behind the viral life cycle. New single-particle techniques provide unprecedented insight into viral assembly. These techniques include resistive-pulse sensing, high-speed atomic force microscopy, interferometric scattering, charge-detection mass spect...
Published in npj Vaccines
Global vaccination programs using live-attenuated oral and inactivated polio vaccine (OPV and IPV) have almost eradicated poliovirus (PV) but these vaccines or their production pose significant risk in a polio-free world. Recombinant PV virus-like particles (VLPs), lacking the viral genome, represent safe next-generation vaccines, however their pro...
Published in Materials (Basel, Switzerland)
The presented research's main objective was to develop the solution to the global problem of using steel waste obtained during rubber recovery during the tire recycling. A detailed comparative analysis of mechanical and physical features of the concrete composite with the addition of recycled steel fibres (RSF) in relation to the steel fibre concre...
