Mahiane, Severin G Marsh, Kimberly Glaubius, Robert Eaton, Jeffrey W
Published in
AIDS (London, England)
The Joint United Nations Programme on HIV/AIDS-supported Spectrum software package is used by most countries worldwide to monitor the HIV epidemic. In Spectrum, HIV incidence trends among adults (aged 15-49 years) are derived by either fitting to seroprevalence surveillance and survey data or generating curves consistent with case surveillance and ...
Jeudy, Sandra Bertaux, Lionel Alempic, Jean-Marie Lartigue, Audrey Legendre, Matthieu Belmudes, Lucid Santini, Sébastien Philippe, Nadège Beucher, Laure Biondi, Emanuele
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Acanthamoeba-infecting Mimiviridae are giant viruses with dsDNA genome up to 1.5 Mb. They build viral factories in the host cytoplasm in which the nuclear-like virus-encoded functions take place. They are themselves the target of infections by 20-kb-dsDNA virophages, replicating in the giant virus factories and can also be found associated with 7-k...
Murmann, Andrea E Bartom, Elizabeth T Schipma, Matthew J Vilker, Jacob Chen, Siquan Peter, Marcus E
Published in
iScience
MicroRNAs (miRNAs) are short double-stranded noncoding RNAs (19-23 nucleotides) that regulate gene expression by suppressing mRNAs through RNA interference. Targeting is determined by the seed sequence (position 2-7/8) of the mature miRNA. A minimal G-rich seed of just six nucleotides is highly toxic to cells by targeting genes essential for cell s...
Robin, Maëlle Chassaing, Manon Loutreul, Julie de Rougemont, Alexis Belliot, Gaël Majou, Didier Gantzer, Christophe Boudaud, Nicolas
Human noroviruses (HuNoVs) are the leading cause of viral foodborne outbreaks worldwide. To date, no available methods can be routinely used to detect infectious HuNoVs in foodstuffs. HuNoVs recognize Histo-Blood Group Antigens (HBGAs) through the binding pocket (BP) of capsid protein VP1, which promotes infection in the host cell. In this context,...
Gottlieb, Sami L Giersing, Birgitte Boily, Marie-Claude Chesson, Harrell Looker, Katharine J Schiffer, Joshua Spicknall, Ian Hutubessy, Raymond Broutet, Nathalie
Published in
Vaccine
Development of a vaccine against herpes simplex virus (HSV) is an important goal for global sexual and reproductive health. In order to more precisely define the health and economic burden of HSV infection and the theoretical impact and cost-effectiveness of an HSV vaccine, in 2015 the World Health Organization convened an expert consultation meeti...
Kamga, Larisa Gil, Anna Song, InYoung Brody, Robin M. Ghersi, Dario Aslan, Nuray Stern, Lawrence J. Selin, Liisa K. Luzuriaga, Katherine
The T cell receptor (TCR) repertoire is an essential component of the CD8 T-cell immune response. Here, we seek to investigate factors that drive selection of TCR repertoires specific to the HLA-A2-restricted immunodominant epitope BRLF1109-117 (YVLDHLIVV) over the course of primary Epstein Barr virus (EBV) infection. Using single-cell paired TCRal...
Zamperin, Gianpiero Lucas, Pierrick Cano, Irene Ryder, David Abbadi, Miriam Stone, David Cuenca, Argelia Vigouroux, Estelle Blanchard, Yannick Panzarin, Valentina
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Published in
Virology Journal
BackgroundNext generation sequencing (NGS) is becoming widely used among diagnostics and research laboratories, and nowadays it is applied to a variety of disciplines, including veterinary virology. The NGS workflow comprises several steps, namely sample processing, library preparation, sequencing and primary/secondary/tertiary bioinformatics (BI) ...
Eaton, J Brown, T Puckett, R Glaubius, R Mutai, K Bao, L Salomon, J Stover, J Mahy, M Hallett, T
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Objectives: Improve models for estimating HIV epidemic trends in sub-Saharan Africa (SSA). Design: Mathematical epidemic model fit to national HIV survey and ANC sentinel surveillance (ANC-SS) data. Methods: We modified EPP to incorporate age and sex stratification (EPP-ASM) to more accurately capture the shifting demographics of maturing HIV epide...
Case, K Johnson, L Mahy, M Marsh, K Supervie, V Eaton, J
Aslam, Yusuf Williamson, James Romashova, Veronika Elder, Elizabeth Krishna, Benjamin Wills, Mark Lehner, Paul Sinclair, John Poole, Emma
Published in
iScience
Human cytomegalovirus establishes a lifelong, latent infection in the human host and can cause significant morbidity and mortality, particularly, in immunocompromised individuals. One established site of HCMV latency and reactivation is in cells of the myeloid lineage. In undifferentiated myeloid cells, such as CD14+ monocytes, virus is maintained ...
