Alexander, Samuel Hibbard, Bill
Published in
Journal of Artificial General Intelligence
In 2011, Hibbard suggested an intelligence measure for agents who compete in an adversarial sequence prediction game. We argue that Hibbard’s idea should actually be considered as two separate ideas: first, that the intelligence of such agents can be measured based on the growth rates of the runtimes of the competitors that they defeat; and second,...
Streblow, Daniel Hirsch, Alec Stanton, Jeffrey Lewis, Anne Colgin, Lois Hessell, Ann Kreklywich, Craig Smith, Jessica Sutton, William Chauvin, David
...
Passively administered monoclonal antibodies (mAbs) given before or after viral infection can prevent or blunt disease. Here, we examine the efficacy of aerosol mAb delivery to prevent infection and disease in rhesus macaques inoculated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant via intranasal and intratrach...
Miwa, Hiromi Antao, Olivia Kelly-Scumpia, Kindra Baghdasarian, Sevana Mayer, Daniel Shang, Lily Sanchez, Gina Archang, Maani Scumpia, Philip Weinstein, Jason
...
New vaccine platforms that activate humoral immunity and generate neutralizing antibodies are required to combat emerging pathogens, including influenza virus. A slurry of antigen-loaded hydrogel microparticles that anneal to form a porous scaffold with high surface area for antigen uptake by infiltrating immune cells as the biomaterial degrades is...
ODriscoll, Megan Buddhari, Darunee Huang, Angkana Waickman, Adam Kaewhirun, Surachai Iamsirithaworn, Sopon Khampaen, Direk Farmer, Aaron Fernandez, Stefan Srikiatkhachorn, Anon
...
Infants less than 1 y of age experience high rates of dengue disease in dengue virus (DENV) endemic countries. This burden is commonly attributed to antibody-dependent enhancement (ADE), whereby concentrations of maternally derived DENV antibodies become subneutralizing, and infection-enhancing. Understanding antibody-related mechanisms of enhanced...
Reeves, Daniel Bacchus-Souffan, Charline Fitch, Mark Abdel-Mohsen, Mohamed Hoh, Rebecca Ahn, Haelee Stone, Mars Hellerstein, Marc McCune, Joseph Schiffer, Joshua
...
Persistence of HIV in people living with HIV (PWH) on suppressive antiretroviral therapy (ART) has been linked to physiological mechanisms of CD4+ T cells. Here, in the same 37 male PWH on ART we measure longitudinal kinetics of HIV DNA and cell turnover rates in five CD4 cell subsets: naïve (TN), stem-cell- (TSCM), central- (TCM), transitional- (T...
Huang, Ying Hejazi, Nima Blette, Bryan Carpp, Lindsay Benkeser, David Montefiori, David McDermott, Adrian Fong, Youyi Janes, Holly Deng, Weiping
...
The COVE trial randomized participants to receive two doses of mRNA-1273 vaccine or placebo on Days 1 and 29 (D1, D29). Anti-SARS-CoV-2 Spike IgG binding antibodies (bAbs), anti-receptor binding domain IgG bAbs, 50% inhibitory dilution neutralizing antibody (nAb) titers, and 80% inhibitory dilution nAb titers were measured at D29 and D57. We assess...
Blengio, Fabiola Hocini, Hakim Richert, Laura Lefebvre, Cécile Durand, Melany Hejblum, Boris P. Tisserand, Pascaline Mclean, Chelsea Luhn, Kerstin Thiébaut, Rodolphe
...
Ebola virus disease is a severe hemorrhagic fever with a high fatality rate. We investigate transcriptome profiles at 3 h, 1 day, and 7 days after vaccination with Ad26.ZEBOV and MVA-BN-Filo. 3 h after Ad26.ZEBOV injection, we observe an increase in genes related to antigen presentation, sensing, and T and B cell receptors. The highest response occ...
Charles-Schoeman, Christina Faure-Kumar, Emmanuelle Ferbas, Kathie Wang, Jennifer Shahbazian, Ani Truong, Linh McMahon, Maureen Yang, Howard FitzGerald, John Bae, Sangmee
...
Antibodies to Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) have been reported in pooled healthy donor plasma and intravenous immunoglobulin products (IVIG). It is not known whether administration of IVIG increases circulating anti-SARS-CoV-2 antibodies (COVID ab) in IVIG recipients. COVID ab against the receptor binding domain of th...
Takahashi, Saki Peluso, Michael Hakim, Jill Turcios, Keirstinne Janson, Owen Routledge, Isobel Busch, Michael Hoh, Rebecca Tai, Viva Kelly, J
...
Serosurveys are a key resource for measuring severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) population exposure. A growing body of evidence suggests that asymptomatic and mild infections (together making up over 95% of all infections) are associated with lower antibody titers than severe infections. Antibody levels also peak a few wee...
Thebault, Simon Gandelman, Stephanie Lane, Camryn Kim, Erin Pileggi, Caitlin Zuroff, Leah Yamashita, Luana Schindler, Matthew Chiu, Charles Berger, Joseph
...
OBJECTIVES: The objective of this study was to report on the development of neuroinvasive West Nile virus (WNV) infection in the context of anti-CD20 monotherapy for multiple sclerosis (MS). METHODS: This is a case series study. RESULTS: In 2021-2022, we observed 4 cases of neuroinvasive WNV infection in our patient population of 2009 patients with...