Saini, Heena Sharma, Harshita Mukherjee, Sudeshna Chowdhury, Shibasish Chowdhury, Rajdeep
Published in
Cancer Cell International
BackgroundOsteosarcoma (OS) is a malignant tumor of the bone mostly observed in children and adolescents. The current treatment approach includes neoadjuvant and adjuvant chemotherapy; however, drug resistance often hinders therapy in OS patients. Also, the post-relapse survival of OS patients is as low as 20%. We therefore planned to understand th...
Wei, Changran Li, Xiangqi
Published in
BMC Cancer
BackgroundBreast cancer (BC) can be divided into five subtypes: Lumina1A, Lumina1B, HER-2 overexpression, Basal-like and Normal breast-like subtype, based on the differently expressed genes in breast cancer tissue. The Hippo signaling pathway plays an indispensable role in BC. The YAP gene is a terminal effector of Hippo pathway, and hyperactivatio...
Zhou, Xiangxiang Chen, Na Xu, Hongzhi Zhou, Xiaoming Wang, Jianhong Fang, Xiaosheng Zhang, Ya Li, Ying Yang, Juan Wang, Xin
...
Published in
Journal of Hematology & Oncology
BackgroundHippo-Yes-associated protein (YAP) signaling is a key regulator of organ size and tumorigenesis, yet the underlying molecular mechanism is still poorly understood. At present, the significance of the Hippo-YAP pathway in diffuse large B-cell lymphoma (DLBCL) is ill-defined.MethodsThe expression of YAP in DLBCL was determined in public dat...
Dasari, Venkata Ramesh Carey, David J. Gogoi, Radhika
Published in
BMC Cancer
BackgroundEpithelial ovarian cancers (EOCs) comprises the majority of malignant ovarian neoplasms. Combination treatment with chemotherapeutic agents seems to be a promising strategy in ovarian cancer (OVCA) patients in order to overcome drug resistance. In this in vitro study, we investigated the therapeutic efficacy of verteporfin (VP) alone and ...
Wang, Bo Shao, Wenyu Shi, Yue Liao, Jiongbo Chen, Xiaojun Wang, Chao
Published in
American Journal of Cancer Research
Yes-associated protein (YAP or YAP1) has been proposed to function as an oncogene in most cancers, with nuclear localization of YAP1 correlating with poor prognosis. Photosensitizer Verteporfin has been proven as an inhibitor of YAP1 through preventing the combination of YAP1 with TEA domain transcription factor (TEAD). We showed previously that th...
García, Patricia Rosa, Lorena Vargas, Sergio Weber, Helga Espinoza, Jaime A. Suárez, Felipe Romero-Calvo, Isabel Elgueta, Nicole Rivera, Vanessa Nervi, Bruno
...
Published in
Cancers
Gallbladder cancer is an aggressive disease with late diagnosis and no efficacious treatment. The Hippo-Yes-associated protein 1 (YAP1) signaling pathway has emerged as a target for the development of new therapeutic interventions in cancers. However, the role of the Hippo-targeted therapy has not been addressed in advanced gallbladder cancer (GBC)...
Sun, Tianyanxin Diaz, Francisco J.
Published in
Reproductive Biology and Endocrinology
BackgroundThe Hippo pathway plays critical roles in regulating cell proliferation, differentiation and survival among species. Hippo pathway proteins are expressed in the ovary and are involved in ovarian function. Deletion of Lats1 causes germ cell loss, ovarian stromal tumors and reduced fertility. Ovarian fragmentation induces nuclear YAP1 accum...
Zucchini, Cinzia Manara, Maria Cristina Cristalli, Camilla Carrabotta, Marianna Greco, Sara Pinca, Rosa Simona Ferrari, Cristina Landuzzi, Lorena Pasello, Michela Lollini, Pier-Luigi
...
Published in
Journal of Experimental & Clinical Cancer Research
BackgroundThe treatment of metastatic osteosarcoma (OS) remains a challenge for oncologists, and novel therapeutic strategies are urgently needed. An understanding of the pathways that regulate OS dissemination is required for the design of novel treatment approaches. We recently identified Rho-associated coiled-coil containing protein kinase 2 (RO...
Wang, Yuting Wang, Lei Wise, James T F Shi, Xianglin Chen, Zhimin
Published in
Toxicology and applied pharmacology
Inflammation is a physiologic response to damage triggered by infection, injury or chemical irritation. Chronic inflammation produces repeated damage to cells and tissues, which can induce a variety of human diseases including cancer. Verteporfin, an FDA approved drug, is used for the treatment of age-related macular degeneration. The anti-tumor ef...
Chuang, Huai-Chia Tan, Tse-Hua
Published in
Journal of Biomedical Science
MAP4K3 (also named GLK) is a serine/threonine kinase, which belongs to the mammalian Ste20-like kinase family. At 22 years of age, GLK was initially cloned and identified as an upstream activator of the MAPK JNK under an environmental stress and proinflammatory cytokines. The data derived from GLK-overexpressing or shRNA-knockdown cell lines sugges...