Quan, Yi Li, Zhi Zhu, Kangshun Liang, Jundi
Published in
Lipids in Health and Disease
BackgroundThis study aimed to explore the effect of inhibiting the Hippo/Yes-associated protein (YAP) signaling pathway on the outcomes of transcatheter arterial chemoembolization (TACE) in treating transplanted hepatocellular carcinoma (HCC).MethodsA transplanted HCC rat model was established. Then, rats were randomly divided into four groups: Sha...
Roelofs, Kelsey A Fabian, Ido Didi Arora, Amit K Cohen, Victoria M L Sagoo, Mandeep S
Published in
Ophthalmology. Retina
To report the long-term outcomes of patients with small, pigmented, posteriorly located choroidal melanoma undergoing primary treatment using photodynamic therapy (PDT) with verteporfin at the London Ocular Oncology Service. Retrospective, interventional, consecutive case series. All patients undergoing primary treatment using PDT with verteporfin ...
Saini, Heena Sharma, Harshita Mukherjee, Sudeshna Chowdhury, Shibasish Chowdhury, Rajdeep
Published in
Cancer Cell International
BackgroundOsteosarcoma (OS) is a malignant tumor of the bone mostly observed in children and adolescents. The current treatment approach includes neoadjuvant and adjuvant chemotherapy; however, drug resistance often hinders therapy in OS patients. Also, the post-relapse survival of OS patients is as low as 20%. We therefore planned to understand th...
Shi-wen, Xu Racanelli, Michael Ali, Aaisham Simon, Amara Quesnel, Katherine Stratton, Richard J. Leask, Andrew
Published in
Journal of Cell Communication and Signaling
Fibrosis is perpetuated by an autocrine, pro-adhesive signaling loop maintained by the synthetic and contractile abilities of myofibroblasts and the stiff, highly-crosslinked extracellular matrix. Transcriptional complexes that are exquisitely responsive to mechanotransduction include the co-activator YAP1, which regulates the expression of members...
Morice, Sarah Mullard, Mathilde Brion, Regis Dupuy, Maryne Renault, Sarah Tesfaye, Robel Brounais-Le Royer, Bénédicte Ory, Benjamin Redini, Françoise Verrecchia, Franck
...
Published in
Cancers
Although some studies suggested that disruption of the Hippo signaling pathway is associated with osteosarcoma progression, the molecular mechanisms by which YAP regulates primary tumor growth is not fully clarified. In addition, the validation of YAP as a therapeutic target through the use of inhibitors in a preclinical model must be demonstrated....
Gu, Chenjian Wu, Yang Guo, Huimin Zhu, Yuanfei Xu, Wei Wang, Yuyan Zhou, Yu Sun, Zhiping Cai, Xia Li, Yutang
...
Published in
Science Bulletin
The SARS-CoV-2 infection is spreading rapidly worldwide. Efficacious antiviral therapeutics against SARS-CoV-2 is urgently needed. Here, we discovered that protoporphyrin IX (PpIX) and verteporfin, two Food and Drug Administration (FDA)-approved drugs, completely inhibited the cytopathic effect produced by SARS-CoV-2 infection at 1.25 μmol/L and 0....
Wei, Changran Li, Xiangqi
Published in
BMC Cancer
BackgroundBreast cancer (BC) can be divided into five subtypes: Lumina1A, Lumina1B, HER-2 overexpression, Basal-like and Normal breast-like subtype, based on the differently expressed genes in breast cancer tissue. The Hippo signaling pathway plays an indispensable role in BC. The YAP gene is a terminal effector of Hippo pathway, and hyperactivatio...
Koytak, Arif Bayraktar, Havvanur Ozdemir, Hakan
Published in
International ophthalmology
The aim of this study is to investigate the results of fluorescein angiography (FA)-guided reduced-fluence photodynamic therapy (PDT) in the treatment of chronic central serous chorioretinopathy (CSCR), with the hypothesis that indocyanine green angiography (ICGA) guidance is avoidable in some cases. This retrospective study includes a consecutive ...
Zhou, Xiangxiang Chen, Na Xu, Hongzhi Zhou, Xiaoming Wang, Jianhong Fang, Xiaosheng Zhang, Ya Li, Ying Yang, Juan Wang, Xin
...
Published in
Journal of Hematology & Oncology
BackgroundHippo-Yes-associated protein (YAP) signaling is a key regulator of organ size and tumorigenesis, yet the underlying molecular mechanism is still poorly understood. At present, the significance of the Hippo-YAP pathway in diffuse large B-cell lymphoma (DLBCL) is ill-defined.MethodsThe expression of YAP in DLBCL was determined in public dat...
Dasari, Venkata Ramesh Carey, David J. Gogoi, Radhika
Published in
BMC Cancer
BackgroundEpithelial ovarian cancers (EOCs) comprises the majority of malignant ovarian neoplasms. Combination treatment with chemotherapeutic agents seems to be a promising strategy in ovarian cancer (OVCA) patients in order to overcome drug resistance. In this in vitro study, we investigated the therapeutic efficacy of verteporfin (VP) alone and ...
