Ong, Wei-Yi Go, Mei-Lin Wang, De-Yun Cheah, Irwin Kee-Mun Halliwell, Barry
Published in
Molecular neurobiology
The SARS-CoV-2 virus that is the cause of coronavirus disease 2019 (COVID-19) affects not only peripheral organs such as the lungs and blood vessels, but also the central nervous system (CNS)-as seen by effects on smell, taste, seizures, stroke, neuropathological findings and possibly, loss of control of respiration resulting in silent hypoxemia. C...
Zhu, Ningwei Liang, Xiao Zhang, Ming Yin, Xiaolan Yang, Hui Zhi, Yajun Ying, Guizhen Zou, Jialing Chen, Lei Yao, Xiaokun
...
Published in
Behavioral and Brain Functions
ObjectiveThe purpose of this study was to evaluate the effect of astaxanthin (AST) on cognition function, inflammatory response and oxidative stress in vascular dementia (VD) mice.MethodVD mice model was established by left unilateral common carotid arteries occlusion (LUCCAO). Following LUCCAO, AST was intragastrically administered for 30 days. Ob...
Zhou, Tiantian Lin, Lu Hao, Chizi Liao, Weijing
Published in
Neuroscience letters
Increasing evidence demonstrated the promising effects of environmental enrichment (EE) on brain recovery and cognitive performance in animal models of various diseases. However, the effect and molecular mechanisms of EE on vascular dementia (VD) remain to be studied. The aim of this study was to explore the effect of EE on cognitive decline and it...
Martins-Filho, Rui Kleber Zotin, Maria Clara Rodrigues, Guilherme Pontes-Neto, Octavio
Published in
Dementia and geriatric cognitive disorders
The damage in the endothelium and the neurovascular unit appears to play a key role in the pathogenesis of vascular cognitive impairment (VCI). Although there have been many advances in understanding the physiopathology of this disease, several questions remain unanswered. The association with other degenerative diseases and the heterogeneity of it...
Damodaran, Thenmoly Cheah, Pike See Murugaiyah, Vikneswaran Hassan, Zurina
Published in
Neurochemistry international
Clitoria ternatea (CT) is an herbal plant that has been used as a memory booster in folk medicine. CT root extract has been proven to restore chronic cerebral hypoperfusion (CCH)-induced memory deficits in a rat model, but the underlying mechanisms and the toxicity profile following repeated exposure have yet to be explored. To investigate the effe...
Song, Min Kyung Kim, Yoon Ju Lee, Jae-Min Kim, Youn-Jung
Published in
Brain research bulletin
Vascular dementia (VaD) is one of the most common types of dementia followed by Alzheimer's disease (AD). Recent studies showed that approximately 30 %-35 % of patients with AD at post-mortem exhibited vascular pathologies, which suggested that mixed dementia may be the most common type of dementia. Permanent bilateral common carotid artery occlusi...
Deng, Minzhen Huang, Liping Zhong, Xiaoqin Huang, Manting
Published in
Journal of molecular neuroscience : MN
This study tried to investigate the dynamic changes of Beclin-1 in the hippocampus of male mice with vascular dementia (VD) at different time points. The mouse model of VD was established by the four-vessel blocking method. Then, the VD mice were randomly divided into five groups (n = 12) according to the disease duration: the 0.1-day model group, ...
Davison, William J. Myint, Phyo K. Loke, Yoon K. Ravenhill, Garth Turner, David Fox, Chris Shepstone, Lee Potter, John F.
Published in
BMC Geriatrics
BackgroundCognitive impairment and dementia following cerebrovascular disease are increasingly common in the UK. One potential strategy to prevent post-stroke cognitive decline is multimodal vascular risk factor management. However, its efficacy remains uncertain and its application in vulnerable patients with incident cerebrovascular disease and e...
Drag, Lauren L. Mlynash, Michael Nassar, Huda Osborn, Elizabeth Kim, Da E. Angst, Martin S. Aghaeepour, Nima Buckwalter, Marion Lansberg, Maarten G.
Published in
BMC Neurology
BackgroundStroke increases the risk of cognitive impairment even several years after the stroke event. The exact mechanisms of post-stroke cognitive decline are unclear, but the immunological response to stroke might play a role. The aims of the StrokeCog study are to examine the associations between immunological responses and long-term post-strok...
Kim, Do-Hyung Jeong, Seong-Nyum Lee, Jae-Hong
Published in
Journal of Periodontal & Implant Science
