Emerging variants of SARS-CoV-2 raise concerns about vaccine efficiency. Here, the authors present a post-hoc analysis for the ChAdOx1 nCoV-19 (AZD1222) vaccine trial in Brazil and provide efficacy against symptomatic COVID-19 caused by the Zeta (P.2) and other variants.
Side Effects of Drugs Annual
As of June 29th, 2021, the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), or COVID-19, has resulted in a global incidence of 181 007 816 cases, with corresponding mortality of 3 927 222 or a mortality rate of 2.2%. Global COVID-19 vaccination efforts have resulted in about 2.97 billion doses administered or approximately ...
European Journal of Pharmacology
Environmental Science and Pollution Research International
Coronaviruses are terrifically precise and adapted towards specialized respiratory epithelial cells, observed in organ culture and human volunteers both. This virus is found to possess an unpredictable anti-viral T-cell response which in turn results in T-cell activation and finally apoptosis, leading to cytokine storm and collapse of the whole imm...
The rapid development and application of different SARS-Cov2 vaccines world-wide has resulted in impressive efficacy and protection from this deadly pandemic. However, the existence of different and continuously developing vaccine candidates coupled with the likelihood of continued application due to both waning immune responses and emergence of vi...
Gastroenterologia y hepatologia
Patients with certain immune-mediated inflammatory diseases, such as rheumatoid arthritis (RA) and inflammatory bowel disease (IBD), have an increased risk of severe infectious diseases than the general population, which are mainly associated with the immunosuppressive treatments that they receive. These treatments act on the immune system through ...
Best practice & research. Clinical obstetrics & gynaecology
As we live through the history-making pandemic of coronavirus disease 2019 (COVID-19), it is timely to consider the lessons that history has taught us about vaccine-preventable disease in pregnancy. Vaccinations have earned an established place in pregnancy care to prevent communicable disease in the mother, fetus and newborn. The improvements in m...
Dermatology and Therapy
More than 12 months have passed since the World Health Organization (WHO) declared Coronavirus Disease 19 (COVID-19), caused by the SARS-CoV2 virus, to be a pandemic on 11 March 2020. The entire world scientific community agrees that at this time vaccine is the most promising weapon to combat the infection and the severity of the disease. According...
Nature Reviews. Materials
The immune response to a vaccine is characterized by a complex time-dependent interplay between various cell types and molecules in different tissues in our body. This Review explores materials-based strategies for the spatial and temporal control of the mechanisms that underlie vaccine immune responses.
Signal Transduction and Targeted Therapy