The one health problem of azole resistance in Aspergillus fumigatus: current insights and future research agenda
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status: published
Review of influenza-associated pulmonary aspergillosis in ICU patients and proposal for a case definition: an expert opi...
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PURPOSE: Invasive pulmonary aspergillosis is increasingly reported in patients with influenza admitted to the intensive care unit (ICU). Classification of patients with influenza-associated pulmonary aspergillosis (IAPA) using the current definitions for invasive fungal diseases has proven difficult, and our aim was to develop case definitions for ...
Review of influenza-associated pulmonary aspergillosis in ICU patients and proposal for a case definition : an expert op...
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Purpose Invasive pulmonary aspergillosis is increasingly reported in patients with influenza admitted to the intensive care unit (ICU). Classification of patients with influenza-associated pulmonary aspergillosis (IAPA) using the current definitions for invasive fungal diseases has proven difficult, and our aim was to develop case definitions for I...
In vitro antifungal activity of a novel topical triazole PC945 against emerging yeast Candida auris
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Objectives Management of Candida auris infection is difficult as this yeast exhibits resistance to different classes of antifungals, necessitating the development of new antifungals. The aim of this study was to investigate the susceptibility of C. auris to a novel antifungal triazole, PC945, optimized for topical delivery. Methods A collection of ...
Isavuconazole Versus Caspofungin in the Treatment of Candidemia and Other Invasive Candida Infections: The ACTIVE Trial....
...Published in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Isavuconazole was compared to caspofungin followed by oral voriconazole in a Phase 3, randomized, double-blind, multinational clinical trial for the primary treatment of patients with candidemia or invasive candidiasis. Adult patients were randomized 1:1 to isavuconazole (200 mg intravenous [IV] three-times-daily [TID] for 2 days, followed by 200 m...
Dynamic ploidy changes drive fluconazole resistance in human cryptococcal meningitis
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Background: Cryptococcal meningitis (CM) causes an estimated 180,000 deaths annually, predominantly in sub-Saharan Africa, where most patients receive fluconazole (FLC) monotherapy. While relapse after FLC monotherapy with resistant strains is frequently observed, the mechanisms and impact of emergence of FLC resistance in human CM are poorly under...
High prevalence of triazole resistance in clinical Aspergillus fumigatus isolates in a specialist cardiothoracic centre....
Published in International journal of antimicrobial agents
To evaluate the prevalence of triazole-resistant Aspergillus fumigatus and common molecular cyp51A polymorphisms amongst clinical isolates in a specialised cardiothoracic centre in London, UK. All A. fumigatus isolates were prospectively analysed from April 2014 to March 2016. Isolates were screened with a four-well VIPcheck™ plate to assess triazo...
In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection.
...Published in Antimicrobial agents and chemotherapy
The antifungal effects of the novel triazole PC1244, designed for topical or inhaled administration, against Aspergillus fumigatus were tested in a range of in vitro and in vivo studies. PC1244 demonstrated potent antifungal activities against clinical A. fumigatus isolates (n = 96) with a MIC range of 0.016 to 0.25 μg/ml, whereas the MIC range for...
In vitro and in vivo antifungal profile of a novel and long-acting inhaled azole, PC945, on aspergillus fumigatus infect...
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The profile of PC945, a novel triazole antifungal designed for administration via inhalation, was assessed in a range of in vitro and in vivo studies. PC945 was characterized as a potent, tightly binding inhibitor of Aspergillus fumigatus sterol 14α-demethylase (CYP51A and CYP51B) activity (50% inhibitory concentrations [IC50s], 0.23 μM and 0.22 μM...
Exposure of Aspergillus fumigatus to T-2 toxin results in a stress response associated with exacerbation of aspergillosi...
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Aspergillus fumigatus is a ubiquitous airborne pathogen. Saprophytic growth in the presence of environmental mycotoxins might affect its fitness and virulence. T-2 toxin (T-2) is a trichothecene mycotoxin produced by Fusarium spp. in various substrates. This study aimed to evaluate the effects of T-2 on the fitness of A. fumigatus in vitro and its ...
