Distribution and virulence of fungal species isolated from yam (Dioscorea spp.) tubers in three agroecological zones of ...
Peer Review
Double-stranded RNA reduces growth rates of the gut parasite Crithidia mellificae
Parasites of managed bees can disrupt the colony success of the host, but also influence local bee-parasite dynamics, which is regarded as a threat for wild bees. Therapeutic measures have been suggested to improve the health of managed bees, for instance, exploiting the bees' RNA interference (RNAi) pathway to treat against viral pathogens. Gut tr...
Evidence that the stress hormone cortisol regulates biofilm formation differently among Flavobacterium columnare isolate...
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The impact of cortisol on Flavobacterium columnare biofilm formation was explored. Firstly, the dynamics of biofilm formation by one highly (HV) and one low virulent (LV) F. columnare isolate with and without the stress hormone cortisol under microfluidic flow conditions was characterized. This to confirm that F. columnare cells could form biofilm ...
Various Evolutionary Trajectories Lead to Loss of the Tobramycin-Potentiating Activity of the Quorum-Sensing Inhibitor B...
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Combining antibiotics with potentiators that increase their activity is a promising strategy to tackle infections caused by antibiotic-resistant bacteria. As potentiators do not interfere with essential processes, it has been hypothesized that they are less likely to induce resistance. However, evidence supporting this hypothesis is lacking. In the...
Understanding the role of interactions between host and Mycobacterium tuberculosis under hypoxic condition: an in silico...
Background: Mycobacterium tuberculosis infection in humans is often associated with extended period of latency. To adapt to the hostile hypoxic environment inside a macrophage, M. tuberculosis cells undergo several physiological and metabolic changes. Previous studies have mostly focused on inspecting individual facets of this complex process. In o...
Heterogeneity in pneumolysin expression governs the fate of Streptococcus pneumoniae during blood-brain barrier traffick...
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Outcome of host-pathogen encounter is determined by the complex interplay between protective bacterial and host defense strategies. This complexity further amplifies with the existence of cell-to-cell phenotypic heterogeneity in pathogens which remains largely unexplored. In this study, we illustrated that heterogeneous expression of pneumolysin (P...
Logic of two antagonizing intra-species quorum sensing systems in bacteria
Bacteria release signaling molecules into the surrounding environment and sense them when present in their proximity. Using this strategy, a cell estimates the number of neighbors in its surrounding. Upon sensing a critical number of individuals, bacteria coordinate a number of cellular processes. This density-dependent control of gene expression a...
Comparative analysis of pathogenic and nonpathogenic Fusarium oxysporum populations associated with banana on a farm in ...
Fusarium wilt is one of the most devastating diseases on banana. The causal agent, Fusarium oxysporum f. sp. cubense (Foc) is genetically diverse and its origin and virulence are poorly understood. In this study, pathogenic Foc isolates and nonpathogenic F.oxysporum isolates from Minas Gerais in Brazil were compared using EF-1 and IGS sequences. Th...
Impact of the organic load on the efficacy of chlorine disinfection against acute hepatopancreatic necrosis disease-caus...
Does quorum sensing interference affect the fitness of bacterial pathogens in the real world?
Many bacterial pathogens rely on quorum sensing to control virulence gene expression. Based on numerous experiments conducted under well-defined conditions, quorum sensing interference is considered as a promising strategy to tackle infections and thus might have the potential to (partially) replace antibiotics. Despite the promising results in wel...
