Khodabakhsh, Farnaz Merikhian, Parnaz Eisavand, Mohammad Reza Farahmand, Leila
Published in
Cancer Cell International
VEGF and its receptor family (VEGFR) members have unique signaling transduction system that play significant roles in most pathological processes, such as angiogenesis in tumor growth and metastasis. VEGF-VEGFR complex is a highly specific mitogen for endothelial cells and any de-regulation of the angiogenic balance implicates directly in endotheli...
Zeytun, Hikmet Özkorkmaz, Ebru Gökalp
Published in
Journal of investigative surgery : the official journal of the Academy of Surgical Research
We investigated the therapeutic effects of carvacrol in an experimental esophageal burn rat model with immunohistochemical techniques. Materials and Methods: Three groups were included in this study, composed of eight Wistar albino rats each. The control group was given 1 mL 0.9% (wt/vol) NaCl; esophageal burns were induced in groups 2 and 3 by adm...
Surov, Alexey Wienke, Andreas
Published in
Academic radiology
To date, there are inconsistent data about relationships between 2-deoxy-2 [18F] fluoro-D-glucose positron emission tomography (FDG-PET) and expression of vascular endothelial growth factor (VEGF) and microvessel density (MVD). The aim of the present meta-analysis was to systematize the reported data about associations between maximal standardized ...
Caviedes-Bucheli, Javier Lopez-Moncayo, Luis Fernando Muñoz-Alvear, Hernan Dario Gomez-Sosa, Jose Francisco Diaz-Barrera, Luis Eduardo Curtidor, Hernando Munoz, Hugo Roberto
Published in
BMC Oral Health
BackgroundThe aim of this study was to measure the dental pulp inflammatory response through neuropeptides (SP and CGRP) as a response to occlusal trauma, orthodontic movements and a combination of both, as well as the angiogenic defense mechanism through VEGF expression, which could be the initial step to mineralized tissue formation.MethodsForty ...
Collart, C. Ciccarelli, A. Ivanovitch, K. Rosewell, I. Kumar, S. Kelly, G. Edwards, A. Smith, J. C.
Published in
BMC Developmental Biology
BackgroundVasculogenesis in amniotes is often viewed as two spatially and temporally distinct processes, occurring in the yolk sac and in the embryo. However, the spatial origins of the cells that form the primary intra-embryonic vasculature remain uncertain. In particular, do they obtain their haemato-endothelial cell fate in situ, or do they migr...
El Shorbagy, Shereen abuTaleb, Fouad Labib, Hany A Ebian, Huda Harb, Ola A Mohammed, Mona Saeed Rashied, Hanaa A Elbana, Khaled A Haggag, Rasha
Published in
Journal of gastrointestinal cancer
Hepatocellular carcinoma (HCC) is a major health problem. HCC burden has been increasing in Egypt in the past 10 years. Most HCC cases are diagnosed at an advanced stage with limited treatment options. Sorafenib is the standard therapy for advanced HCC, but the effectiveness is not satisfied. Metformin may decrease the risk of HCC development in di...
Mundo, William Wolfson, Gabriel Moore, Lorna G Houck, Julie A Park, Do Julian, Colleen G
Published in
American journal of physiology. Heart and circulatory physiology
Perinatal hypoxia induces permanent structural and functional changes in the lung and its pulmonary circulation that are associated with the development of pulmonary hypertension (PH) in later life. The mechanistic target of the rapamycin (mTOR) pathway is vital for fetal lung development and is implicated in hypoxia-associated PH, yet its involvem...
Maasar, Mohd-Firdaus Turner, Daniel C. Gorski, Piotr P. Seaborne, Robert A. Strauss, Juliette A. Shepherd, Sam O. Cocks, Matt Pillon, Nicolas J. Zierath, Juleen R. Hulton, Andrew T.
...
Published in
Frontiers in Physiology
The methylome and transcriptome signatures following exercise that are physiologically and metabolically relevant to sporting contexts such as team sports or health prescription scenarios (e.g., high intensity interval training/HIIT) has not been investigated. To explore this, we performed two different sport/exercise relevant high-intensity runnin...
Zhao, Xiaohuan Gao, Min Liang, Jian Chen, Yuhong Wang, Yimin Wang, Yuwei Xiao, Yushu Zhao, Zhenzhen Wan, Xiaoling Jiang, Mei
...
Published in
Frontiers in Cell and Developmental Biology
In age-related macular degeneration (AMD), one of the principal sources of vascular endothelial growth factor (VEGF) is retinal pigment epithelium (RPE) cells under hypoxia or oxidative stress. Solute carrier family 7 member 11 (SLC7A11), a key component of cystine/glutamate transporter, regulates the level of cellular lipid peroxidation, and restr...
Giuppi, Martina La Salvia, Anna Evangelista, Jessica Ghidini, Michele
Published in
Biology
Gastric cancer (GC) is the fifth most frequently diagnosed malignant tumor and the third highest cause of cancer mortality worldwide. For advanced GC, many novel drugs and combinations have been tested, but results are still disappointing, and the disease is incurable in the majority of cases. In this regard, it is critical to investigate the molec...
