Marušić, Miša Korva, Miša Knap, Nataša Bogovič, Petra Lusa, Lara Strle, Klemen Nahtigal Klevišar, Mirijam Vovko, Tomaž Tomažič, Janez Lotrič-Furlan, Stanka
...
Although anti-TBE vaccines are highly effective, vaccine breakthrough (VBT) cases have been reported. With increasing evidence for immune system involvement in TBE pathogenesis, we characterized the immune mediators reflecting innate and adaptive T and B cell responses in neurological and convalescent phase in VBT TBE patients. At the beginning of ...
Wang, Yincang Li, Xiaodong Lv, Hang Sun, Lin Liu, Bo Zhang, Xiaofeng Xu, Xilin
Published in
Frontiers in Pharmacology
Naringin is the main component of Drynaria. Modern pharmacological studies have shown that naringin has a wide range of pharmacological activities, including antioxidant, anti-inflammatory, anti-apoptotic, anti-ulcer, and anti-osteoporosis effects. Its therapeutic effects have been observed in various clinical models, such as atherosclerosis, cardi...
Lin, Hsin-Hung Kuo, Ming-Wei Fan, Tan-Chi Yu, Alice L Yu, John
Published in
Biological research
The distinct arterial and venous cell fates are dictated by a combination of various genetic factors which form diverse types of blood vessels such as arteries, veins, and capillaries. We report here that YULINK protein is involved in vasculogenesis, especially venous formation. In this manuscript, we employed gene knockdown, yeast two-hybrid, FLIM...
Chelleri, Cristina Scala, Marcello De Marco, Patrizia Traverso, Monica Ognibene, Marzia Bruno, Irene Striano, Pasquale Severino, Mariasavina Zara, Federico Diana, Maria Cristina
...
Published in
Frontiers in Pediatrics
Neurofibromatosis type 1 (NF1) is a neurocutaneous syndrome caused by pathogenic variants in the NF1 gene, encoding a multidomain inhibitor of Ras activity. Thus, NF1 is considered a RASopathy and drugs targeting the RAS/mitogen-activated protein kinase (MAPK) pathway, such as the MAP kinase (MEK) 1/2 inhibitor Selumetinib, are promising therapeuti...
Guo, Guo-Xia Wu, Ke-Yue Zhang, Xiao-Yong Lai, Fu-Xiang Tsim, Karl Wah-Keung Qin, Qi-Wei Hu, Wei-Hui
Published in
Journal of ethnopharmacology
Curcumae Longae Rhizoma (CLR) is a safe natural herbal medicine, and which has been widely used for centuries as functional food and health products, but its effects on angiogenesis and related underlying mechanism remain unclear. The abnormal angiogenesis is closely related with various diseases, and therefore the precise control of angiogenesis i...
Jin, Zhong Guo, Qiru Wang, Zheng Wu, Xiao Hu, Wangming Li, Jiali Li, Hongfei Zhu, Song Zhang, Haidi Chen, Zixian
...
Published in
Frontiers in Cardiovascular Medicine
Introduction Ocular abnormalities and the development of retinal vasculature may cause postnatal retinopathy. In the past decade, tremendous progress has been made in identifying the mechanisms that regulate retina vasculature. However, the means of regulating embryonic hyaloid vasculature development is largely unknown. This study aims to determin...
Kumadaki, Kayo Suzuki, Natsumi Tatematsu, Kaoru Doi, Yohei Tsukamoto, Kentaro
Published in
Infection and Immunity
Bartonella species are hemotropic, facultative intracellular bacteria, some of which cause zoonoses, that are widely disseminated among many mammals, including humans. During infection in humans, vascular endothelial cells play a crucial role as a replicative niche for Bartonella, and some are capable of promoting vascular proliferation. Along with...
Qi, Huijie Zhang, Wenxin Wang, Yan Ge, Mengxi Wang, Tianxiao Zhang, Liudi Zhong, Mingkang Shi, Xiaojin Liang, Xiaohua Zhan, Qiong
...
Published in
Journal of chemotherapy (Florence, Italy)
We aimed to investigate the prognostic role of genetic variants of VEGF in advanced NSCLC patients treated with platinum-based chemotherapy. A total of 196 patients with advanced NSCLC treated with first-line platinum-based chemotherapy were enrolled. We evaluated the relationship between VEGF polymorphisms and efficacy outcomes and chemotherapy to...
Navani, Vishal Wells, J Connor Boyne, Devon J Cheung, Winson Y Brenner, Darren M McGregor, Bradley A Labaki, Chris Schmidt, Andrew L McKay, Rana R Meza, Luis
...
Published in
Clinical genitourinary cancer
There are limited data evaluating the activity of cabozantinib (CABO) as second line (2L) therapy post standard of care ipilimumab-nivolumab (IPI-NIVO) or immuno-oncology(IO)/vascular endothelial growth factor inhibitor (VEGFi) combinations (IOVE). Using the IMDC database, we sought to identify the objective response rate, time to treatment failure...
Zong, Yuan Kamoi, Koju Kurozumi-Karube, Hisako Zhang, Jing Yang, Mingming Ohno-Matsui, Kyoko
Published in
Frontiers in Immunology
Introduction HTLV-1 (human T-cell lymphotropic virus type 1) is a retrovirus that infects approximately 20 million people worldwide. Many diseases are caused by this virus, including HTLV-1–associated myelopathy, adult T-cell leukemia, and HTLV-1 uveitis. Intraocular anti–vascular endothelial growth factor (VEGF) antibody injection has been widely ...