Yu, J Liu, Y Y Zhao, J J Li, S X Zhu, H T
Published in
Zhonghua bing li xue za zhi = Chinese journal of pathology
目的： 探讨宫颈腺癌（普通型）活检组织的形态学特征对肿瘤侵袭模式及预后的预测价值。 方法： 收集2010—2019年同济大学附属第一妇婴保健院的32对宫颈腺癌样本（32例分期手术标本，32例活检标本），分析活检标本中肿瘤性坏死碎屑（necrotic tumor debris，NTD）、细胞核级及核分裂象计数与子宫切除标本的间质浸润模式和淋巴结状态的相关性。 结果： 肿瘤浸润模式能很好地应用于宫颈腺癌切除标本，但其在活检标本中的作用有限。由于活检组织较小，仅14例（14/32， 43.8%）活检标本可进行浸润模式分型，与切除标本的符合率为37.5%。活检标本中NTD（9/19）和3级核（11/19）与C型浸润和淋巴结转移密切相关（P
Delara, Ritchie Yang, Jie Buckner-Petty, Skye Magtibay, Paul Butler, Kristina
Published in
Journal of gynecologic oncology
To evaluate the survival impact of imaging vs surgical nodal assessment in patients with cervical cancer stage IB2-IVA prior to definitive chemoradiotherapy (CRT). PubMed, MEDLINE, Cochrane Library, and ClinicalTrials.gov were used to search for publications in English and Chinese over a 50-year period. The Preferred Reporting Items for Systematic ...
Yin, Lijun Chen, Guilin
Published in
Medical science monitor : international medical journal of experimental and clinical research
BACKGROUND Cervical cancer threatens women's health worldwide. Verteporfin (VP), a small-molecule YAP1 inhibitor, inhibits cancer cell growth. This study investigated whether VP could inhibit the proliferation and promote the apoptosis of cervical cancer cells by decreasing SULT2B1 expression. MATERIAL AND METHODS Normal and cancerous cervical cell...
Ren, Shuling Gaykalova, Daria A Guo, Theresa Favorov, Alexander V Fertig, Elana J Tamayo, Pablo Callejas-Valera, Juan Luis Allevato, Mike Gilardi, Mara Santos, Jessica
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The dominant paradigm for HPV carcinogenesis includes integration into the host genome followed by expression of E6 and E7 (E6/E7). We explored an alternative carcinogenic pathway characterized by episomal E2, E4, and E5 (E2/E4/E5) expression. Half of HPV positive cervical and pharyngeal cancers comprised a subtype with increase in expression of E2...
Gagliardi, Alessia Porter, Vanessa L Zong, Zusheng Bowlby, Reanne Titmuss, Emma Namirembe, Constance Griner, Nicholas B Petrello, Hilary Bowen, Jay Chan, Simon K
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Cervical cancer is the most common cancer affecting sub-Saharan African women and is prevalent among HIV-positive (HIV+) individuals. No comprehensive profiling of cancer genomes, transcriptomes or epigenomes has been performed in this population thus far. We characterized 118 tumors from Ugandan patients, of whom 72 were HIV+, and performed extend...
Yamamoto, Akihito Kamoi, Seiryu Ikeda, Mariko Yamada, Takashi Yoneyama, Koichi Takeshita, Toshiyuki
Published in
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
BackgroundRadical hysterectomy (RH) is a type of radical surgery performed for cervical cancer. Urinary dysfunction due to RH exacerbates the postoperative quality of life of cervical cancer patients. The nerve-sparing RH (NSRH) technique has been used as an effective measure to conserve urinary function. However, few reports have been published on...
Okugawa, Kaoru Yahata, Hideaki Sonoda, Kenzo Ohgami, Tatsuhiro Yasunaga, Masafumi Kaneki, Eisuke Kato, Kiyoko
Published in
Journal of gynecologic oncology
For oncologic safety, vaginal radical trachelectomy is generally performed only in patients with cervical cancers smaller than 2 cm. However, because inclusion criteria for abdominal trachelectomy are controversial, we evaluated the safety of abdominal trachelectomy for cervical cancers ≥2 cm. We began performing abdominal trachelectomies at our in...
Kanao, Hiroyuki Aoki, Yoichi Fusegi, Atsushi Takeshima, Nobuhiro
Published in
Journal of Gynecologic Oncology
Objective Previously, indications for laterally extended endopelvic resection (LEER) have excluded patients with sciatica because R0 resection has not been deemed possible [ 1 ]. Because laparoscopy optimizes visualization and thus provides for meticulous dissection, we hypothesized that R0 resection can be achieved by means of laparoscopic LEER in...
Burg, Lara Timmermans, Maite van der Aa, Maaike Boll, Dorry Rovers, Koen de Hingh, Ignace van Altena, Anne
Published in
Journal of Gynecologic Oncology
Objective Peritoneal metastases (PM) are a challenge in gynecological cancers, but its appearance has never been described in a population-based study. Therefore, we describe the incidence of PM and identify predictors that increase the probability of peritoneal spread. Methods All ovarian, endometrial and cervical cancer patients diagnosed in the ...
Clarke, Megan A Darragh, Teresa M Nelson, Erin Unger, Elizabeth R Zuna, Rosemary Cremer, Miriam Stockdale, Colleen K Einstein, Mark H Wentzensen, Nicolas
ObjectiveWe adapted the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool for studies of cervical cancer screening and management and used the adapted tool to evaluate the quality of studies included in a systematic review supporting the 2019 Risk-Based Management Consensus Guidelines.MethodsWe evaluated the quality of all studies...
