Cordonnier, Axel
Le cancer de la prostate est un problème majeur de santé publique, avec plus de 1 million de cas estimés en 2018 dans le monde. La principale stratégie thérapeutique repose sur l’exérèse de la prostate, approche toutefois limitée par un nombre important de marges positives (21 à 37%) augmentant le risque de rechute biologique. Une stratégie promett...
Mendez-Gonzalez, Diego Silva-Ibáñez, Pedro P Valiente-Dies, Fernando Calderón, Oscar G Mendez-Gonzalez, Juan L Laurenti, Marco Egatz-Gómez, Ana Díaz, Elena Rubio-Retama, Jorge Melle, Sonia
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Published in
Journal of colloid and interface science
In this work, we present a luminescence platform that can be used as point of care system for determining the presence and concentration of specific oligonucleotide sequences. This sensor exhibited a limit of detection as low as 50 fM by means of: (i) the use of single-stranded DNA (ssDNA) functionalized magnetic microparticles that captured and co...
Martínez, Raquel Polo, Ester Barbosa, Silvia Taboada, Pablo del Pino, Pablo Pelaz, Beatriz
Published in
Journal of Nanobiotechnology
BackgroundThe unique upconversion properties of rare-earth-doped nanoparticles offers exciting opportunities for biomedical applications, in which near-IR remote activation of biological processes is desired, including in vivo bioimaging, optogenetics, and light-based therapies. Tuning of upconversion in purposely designed core–shell nanoparticles ...
Ali, Muhsin Sajid, Memoon Khalid, Muhammad Asad Ullah Kim, Soo Wan Lim, Jong Hwan Huh, Dongeun Choi, Kyung Hyun
Published in
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Vaspin is a protein present in human serum that can cause type-2 diabetes, obesity, and other cardiovascular diseases. We report fluorescent upconverting nanoparticles (UCNPs)-based lateral flow biosensor for ultrasensitive detection of Vaspin. A pair (primary and secondary) of cognate aptamers was used that has duo binding with Vaspin. UCNPs with ...
Ford, Peter C
Ford, Peter C
Tajon, Cheryl A Yang, Hao Tian, Bining Tian, Yue Ercius, Peter Schuck, P James Chan, Emory M Cohen, Bruce E
Chemical sensing in living systems demands optical sensors that are bright, stable, and sensitive to the rapid dynamics of chemical signaling. Lanthanide-doped upconverting nanoparticles (UCNPs) efficiently convert near infrared (NIR) light to higher energy emission and allow biological systems to be imaged with no measurable background or photoble...
Tajon, Cheryl A. Yang, Hao Tian, Bining Tian, Yue Ercius, Peter Schuck, P. James Chan, Emory M. Cohen, Bruce E.
Published in
Optical Materials
Chemical sensing in living systems demands optical sensors that are bright, stable, and sensitive to the rapid dynamics of chemical signaling. Lanthanide-doped upconverting nanoparticles (UCNPs) efficiently convert near infrared (NIR) light to higher energy emission and allow biological systems to be imaged with no measurable background or photoble...
Zhao, Peiqi Ji, Wei Zhou, Shiyong Qiu, Lihua Li, Lanfang Qian, Zhengzi Liu, Xianming Zhang, Huilai Cao, Xuchen
Published in
Materials science & engineering. C, Materials for biological applications
The fluorescence-guided photothermal therapy (FPTT) has great potential in cancer treatment. However, the conventional FPTT has to be stimulated by external light, which tends to increase background noise and leads to the inaccurate infrared light irradiation for PTT. In this study, upconverting and persistent luminescent nanocarriers (UPLNs) loade...
Mrazek, Jiri Kettou, Sofiane Matuska, Vit Svozil, Vit Huerta-Angeles, Gloria Pospisilova, Martina Nesporova, Kristina Velebny, Vladimir
Published in
Journal of Nanoparticle Research
Hyaluronic acid (HA)-coated inorganic nanoparticles display enhanced interaction with the CD44 receptors which are overexpressed in many types of cancer cells. Here, we describe a modification of core-shell β-NaY0.80Yb0.18Er0.02F4@NaYF4 nanoparticles (UCNP) by HA derivative bearing photo-reactive groups. UCNP capped with oleic acid were firstly tra...