Ledergerber, Martina Lang, Brian M. Heinrich, Henriette Biedermann, Luc Begré, Stefan Zeitz, Jonas Krupka, Niklas Rickenbacher, Andreas Turina, Matthias Greuter, Thomas
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Published in
BMC Gastroenterology
BackgroundAbdominal pain is a frequent symptom in patients with inflammatory bowel disease (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC). Pain can result from ongoing inflammation or functional disorders imitating irritable bowel syndrome (IBS). Several single-nucleotide polymorphisms (SNPs) have been associated with IBS. However...
Iwaya, Mai Ota, Hiroyoshi Nakajima, Tomoyuki Uehara, Takeshi Riddell, Robert Conner, James
Published in
BMC Cancer
BackgroundLeucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), a component of the Wnt receptor complex, is thought to lineage label gastric and intestinal stem cells. LGR5 expression is increased in colorectal carcinoma (CRC) compared to normal tissue. Colitis associated colorectal adenocarcinoma (CAC) often shows distinct morphologi...
Berkovitch, Gil Cohen, Shlomi Lubetzky, Ronit Singer, Dana Yerushalmy-Feler, Anat
Published in
BMC Pediatrics
BackgroundThe effect of biologic therapy on the incidence of inflammatory bowel disease (IBD)-related hospitalizations is controversial. The high efficacy of biologic agents is weighted against potential therapy-related adverse events, however, there are no data on the effect of biologic therapy on the indications for hospitalization in IBD. We aim...
Gupta, Annu Wash, Christopher Wu, Yingxing Sorrentino, Dario Nguyen, Vu Q
Published in
Digestive diseases and sciences
Inflammatory bowel disease (IBD) patients are at increased risk of developing Clostridioides difficile infection (CDI). Common methods to diagnose CDI involve a combination of tests including the toxin A/B enzyme immunoassay (Toxin) and toxin gene polymerase chain reaction assay (PCR). Disease outcomes in Toxin+ versus Toxin-PCR+ IBD patients remai...
Ham, Nam Seok Hwang, Sung Wook Oh, Eun Hye Kim, Jeongseok Lee, Ho-Su Park, Sang Hyoung Yang, Dong-Hoon Ye, Byong Duk Byeon, Jeong-Sik Myung, Seung-Jae
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Published in
Digestive diseases and sciences
Previous studies have shown vitamin D status to be associated with disease activity in patients with inflammatory bowel disease (IBD), but its influence on the clinical course of IBD has not been established. We aimed to analyze whether the serum 25-hydroxyvitamin D3 [25(OH)D] status is associated with clinical characteristics and affects the risk ...
Lee, Joon Seop Lee, Hyun Seok Jang, Byung Ik Kim, Eun Soo Kim, Sung Kook Kim, Kyeong Ok Lee, Yoo Jin Lee, Hyun Jik Kim, Eun Young Jung, Yun Jin
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Published in
Digestive diseases and sciences
The prevalence and risk factors of low bone mineral density (BMD) in Asian patients newly diagnosed with inflammatory bowel disease (IBD) have not been fully suggested. We aimed to examine the prevalence and risk factors of low BMD in young Korean patients newly diagnosed with IBD. We prospectively enrolled 132 patients aged less than 50 years and ...
Watanabe, Chikako Nagahori, Masakazu Fujii, Toshimitsu Yokoyama, Kaoru Yoshimura, Naoki Kobayashi, Taku Yamagami, Hirokazu Kitamura, Kazuya Takashi, Kagaya Nakamura, Shiro
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Published in
Digestive diseases and sciences
Adherence to medications is important to maintain disease under control and to prevent complications in pregnant patients with ulcerative colitis (UC). To evaluate the incidence of non-adherence during pregnancy and its effect on relapse and pregnancy outcomes, we conducted a multicenter prospective study using a patient self-reporting system witho...
Ikeuchi, Aiko Kakiuchi, Toshihiko Ibi, Arisa Matsuo, Muneaki
Published in
Clinical journal of gastroenterology
Corticosteroids and biologics are used to treat moderate-to-severe active pediatric ulcerative colitis (UC); however, it is often difficult to continue administration because of systemic side reactions. Vedolizumab is considered to have few adverse effects due to its mechanism of action and it is expected to be used in children, but the long-term a...
Qualter, Pamela Rouncefield-Swales, Alison Bray, Lucy Blake, Lucy Allen, Steven Probert, Chris Crook, Kay Carter, Bernie
Published in
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
Adolescents and young adults (AYA) with Inflammatory Bowel Disease (IBD) report higher depressive symptoms and anxiety compared to healthy controls, with disease severity and abdominal pain being important factors. In the current study, building on what young people had told us in our previous work, we examined whether embarrassment of the conditio...
Kayashima, Atsuto Shimozaki, Keitaro Hirata, Kenro Mutaguchi, Makoto Takabayashi, Kaoru Hayashi, Yuichiro Hosoe, Naoki Ogata, Haruhiko Sujino, Tomohisa Kanai, Takanori
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Published in
Clinical journal of gastroenterology
Immune checkpoint inhibitors (ICPI) have been reported to be effective in various carcinomas. They excessively activate the immune system, resulting in frequent immune-related adverse events (irAEs). Colitis induced by ICPI is one of the most common and is known as immune-mediated colitis (IMC). Although IMC and inflammatory bowel disease (IBD) are...
