Mohamed, Sarah S. Abdeltawab, Nourtan F. Wadie, Walaa Ahmed, Lamiaa A. Ammar, Ramy M. Rabini, Sabine Abdel-Aziz, Heba Khayyal, Mohamed T.
Published in
BMC Complementary Medicine and Therapies
BackgroundThe standardized herbal preparation, STW 5, is effective clinically in functional gastrointestinal disorders and experimentally in ulcerative colitis (UC). The present study explores whether the beneficial effect of STW 5 involves influencing the intestinal microbiota.MethodsUC was induced in Wistar rats by feeding them 5% dextran sodium ...
Ng, Hon Yan Guttman, Orlee R. Tucker, Lori B.
Published in
BMC Rheumatology
BackgroundChronic Recurrent Multifocal Osteomyelitis (CRMO) is a condition characterized by sterile bone inflammation, usually occurring in childhood. Although the etiology remains unclear, this condition has been associated with inflammatory bowel disease (IBD). Primary sclerosing cholangitis (PSC) and Autoimmune Hepatitis (AIH) are also uncommon ...
Kumar, Anand Teslova, Tatiana Taub, Erin Miller, Joshua D Lukin, Dana J
Published in
Digestive diseases and sciences
Diabetes mellitus (DM) and inflammatory bowel diseases (IBD) are chronic systemic illnesses associated with chronic inflammation, dysbiosis, impaired immune function, and infection risk. The impact of DM in modifying disease activity in patients with IBD remains largely unknown. To investigate the impact of DM on IBD-related disease outcomes, morta...
Wang, Yan Wang, Nan Cui, Lianlian Li, Yan Cao, Zhenfeng Wu, Xing Wang, Qianhan Zhang, Bo Ma, Caixia Cheng, Yanbo
...
Published in
Inflammation
Ulcerative colitis (UC) is a refractory chronic colitis disease with the particularly complex cause. Recently, long noncoding RNAs (lncRNAs) have been reported to be related to the development of UC. LncRNA MEG3 has been proved to play an anti-inflammatory role in a variety of inflammatory diseases, which share similar pathogenesis with UC, indicat...
Olaiya, Babatunde Renelus, Benjamin D Filon, Mikolaj Saha, Sumona
Published in
Digestive diseases and sciences
Total abdominal colectomy (TAC) is a treatment modality of last recourse for patients with severe and/or refractory ulcerative colitis (UC). The goal of this study is to evaluate temporal trends and treatment outcomes following TAC among hospitalized UC patients in the biologic era. We queried the National Inpatient Sample (NIS) to identify patient...
Hirten, Robert P Stanley, Stephanie Danieletto, Matteo Borman, Zachary Grinspan, Ari Rao, Prameela Sauk, Jenny Chang, Lin Arnrich, Bert Bӧttinger, Erwin
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Published in
Digestive diseases and sciences
Wearable devices are designed to capture health-related and physiological data. They may be able to improve inflammatory bowel disease management and address evolving research needs. Little is known about patient perceptions for their use in the study and management of inflammatory bowel disease. The aim of this survey study is to understand patien...
Perry, Courtney Fischer, Kyle Elmoursi, Ahmed Kern, Cody Currier, Alden Kudaravalli, Praneeth Akanbi, Olalekan Tripathi, Nishant Yarra, Pradeep Su, Leon
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Published in
Digestive diseases and sciences
The Gemini trial failed to detect a significant difference in response rate for patients with ulcerative colitis (UC) randomized to standard (every 8 week) vedolizumab dosing vs escalated (every 4 week) dosing. Subsequent real-world data imply the Gemini trial design may have obscured a benefit of escalated dosing. We investigated outcomes after ve...
Shimada, Norimitsu Ohge, Hiroki Kitagawa, Hiroki Yoshimura, Kosuke Shigemoto, Norifumi Uegami, Shinnosuke Watadani, Yusuke Uemura, Kenichiro Takahashi, Shinya
Published in
BMC Surgery
BackgroundThe incidence of postoperative venous thromboembolism (VTE) is high in patients with inflammatory bowel disease. We aimed to analyze the incidence and predictive factors of postoperative VTE in patients with ulcerative colitis.MethodsPatients with ulcerative colitis who underwent colon and rectum surgery during 2010–2018 were included. We...
Wetzel, Alexandra Scholtka, Bettina Schumacher, Fabian Rawel, Harshadrai Geisendörfer, Birte Kleuser, Burkhard
Published in
International journal of molecular sciences
Ulcerative colitis (UC), a severe chronic disease with unclear etiology that is associated with increased risk for colorectal cancer, is accompanied by dysregulation of cytokines. Epstein-Barr virus-induced gene 3 (EBI3) encodes a subunit in the unique heterodimeric IL-12 cytokine family of either pro- or anti-inflammatory function. After having re...
De Simone, Belinda Davies, Justin Chouillard, Elie Di Saverio, Salomone Hoentjen, Frank Tarasconi, Antonio Sartelli, Massimo Biffl, Walter L. Ansaloni, Luca Coccolini, Federico
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Published in
World Journal of Emergency Surgery
BackgroundDespite the current therapeutic options for the treatment of inflammatory bowel disease, surgery is still frequently required in the emergency setting, although the number of cases performed seems to have decreased in recent years.The World Society of Emergency Surgery decided to debate in a consensus conference of experts, the main perti...
