Hanna, Ramy M. Merin, Noah Burwick, Richard M. Abdelnour, Lama Selamet, Umut Yanny, Beshoy Bui, Patrick Fouad, Mary Kurtz, Ira
Published in
Thrombosis Journal
BackgroundAtypical hemolytic uremic syndrome is a rare group of disorders that have in common underlying complement amplifying conditions. These conditions can accelerate complement activation that results in a positive feedback cycle. The known triggers for complement activation can be diverse and include, infection, autoimmune disease, and malign...
Johnson, Christopher M. Linzay, Catherine D. Dassopoulos, Themistocles
Published in
Current Gastroenterology Reports
Purpose of ReviewRecent years have brought about several advances in the treatment of patients with ulcerative colitis (UC). Here, we discuss salient recommendations of recent treatment guidelines; review the efficacy, safety, and real-world data of vedolizumab and tofacitinib; appraise their place vis-à-vis established agents; and consider the new...
Shi, Xiao Chen, Qi Wang, Fen
Published in
Stem Cell Research & Therapy
ObjectiveTo explore the promising use of mesenchymal stem cells (MSCs) for ulcerative colitis (UC).MethodsStudies reporting MSC treatment on UC were searched on five databases. Methodological quality was assessed based on the SYRCLE’s Risk of Bias (RoB) tool and MINORS tool. Data analysis was conducted using Engauge Digitizer 10.8 and Stata 14.0.Re...
Windsor, Joseph W. Kaplan, Gilaad G.
Published in
Current Gastroenterology Reports
Purpose of ReviewOnce thought a disease of Western civilizations, the inflammatory bowel diseases (IBD) impose a global burden, now penetrating populations in Asia, Africa, and South America. We summarize similarities and differences in the epidemiology of IBD globally, highlighting gaps in knowledge where future study is needed.Recent FindingsWhil...
Hnatyszyn, Andrzej Hryhorowicz, Szymon Kaczmarek-Ryś, Marta Lis, Emilia Słomski, Ryszard Scott, Rodney J. Pławski, Andrzej
Published in
Hereditary Cancer in Clinical Practice
BackgroundColorectal cancer (CRC) and inflammatory bowel disease (IBD) are the most prevalent diseases of the digestive system, and their association is unequivocal. A long-standing inflammatory process is one of the causes of sporadic as well as inherited cancers as it impacts on malignant transformation in a wide variety of neoplastic diseases, i...
Tian, Yan Zhou, Yan Huang, Sisi Li, Jun Zhao, Kui Li, Xiaohui Wen, Xiangchen Li, Xiao-an
Published in
BMC Gastroenterology
BackgroundFecal microbiota transplantation may contribute to disease remission in ulcerative colitis; however, the factors that determine the effects of treatment remain unknown. The aim of the present study was to prospectively investigate the clinical efficacy of fecal microbiota transplantation in patients with ulcerative colitis and identify th...
Tian, Yu Zheng, Yue Teng, Guigen Li, Junxia Wang, Huahong
Published in
BMC Gastroenterology
BackgroundMicrocirculatory disturbance is an important factor in the pathogenesis of Inflammatory Bowel Disease (IBD) but there have been few studies in this field. Confocal Laser Endomicroscopy (CLE) has been used over the last 10 years and has made it possible to explore the changes in microcirculation of the colonic mucosa.MethodsWe retrospectiv...
Gao, Caifang Liu, Lijuan Zhou, Yangyang Bian, Zhaoxiang Wang, Shengpeng Wang, Yitao
Published in
Chinese Medicine
Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory disease that comprises ulcerative colitis (UC) and Crohn’s disease (CD). IBD involves the ileum, rectum, and colon, and common clinical manifestations of IBD are diarrhea, abdominal pain, and even bloody stools. Currently, non-steroidal anti-inflammatory drugs, glucocorticoid...
Gazouli, Maria Dovrolis, Nikolas Franke, Andre Spyrou, George M. Sechi, Leonardo A. Kolios, George
Published in
Gut Pathogens
BackgroundCrohn’s disease (CD) and Ulcerative colitis (UC) are the two main entities of inflammatory bowel disease (IBD). Previous works have identified more than 200 risk factors (including loci and signaling pathways) in populations of predominantly European ancestry. Our study was conducted on an extended population-specific cohort of 573 Greek ...
Mokhtar, Norfilza Mohd Nawawi, Khairul Najmi Muhammad Verasingam, Jaarvis Zhiqin, Wong Sagap, Ismail Azman, Zairul Azwan Mohd Mazlan, Luqman Hamid, Hamzaini Abdul Yaacob, Nur Yazmin Rose, Isa Mohamed
...
Published in
BMC Public Health
BackgroundInflammatory bowel disease (IBD) was once considered as a Western disease. However, recent epidemiological data showed an emerging trend of IBD cases in the Eastern Asia countries. Clinico-epidemiological data of IBD in Malaysia is scarce. This study aimed to address this issue.MethodsRetrospective analysis of ulcerative colitis (UC) and ...
