China Scholarship Council / Federal Ministry for Economic Cooperation and Development, Germany / Deutsche Gesellschaft für Internationale Zusammenarbeit / International Fund for Agricultural Development / Australian Centre for International Agricultural Research / Irish Aid / European Union / United States Agency for International Development / Pee...
Metabolic profiling, metabonomics and metabolomics are terms coined in the late 1990s as they emerged as the newest ‘omics’ technology at the time. This line of research enquiry uses spectroscopic analytical platforms, which are mainly nuclear magnetic resonance spectroscopy and mass spectrometry (MS), to acquire a snapshot of metabolites, the end ...
AIM: To review current alcohol hangover research in animals and humans and evaluate key evidence for contributing biological factors. METHOD: Narrative review with alcohol hangover defined as the state the day after a single episode of heavy drinking, when the alcohol concentration in the blood approaches zero. RESULTS: Many of the human studies of...
The aim of this study was to determine the toxicokinetic characteristics of ZEN and its modified forms, alpha-zearalenol (alpha-ZEL), beta-zearalenol (beta-ZEL), zearalenone-14-glucoside (ZEN14G), and zearalenone-14-sulfate (ZEN14S), including presystemic and systemic hydrolysis in pigs. Crossover pig trials were performed by means of intravenous a...
In order to study the renal function, in terms of glomerular filtration and effective renal plasma flow, in broiler chickens and pigs, an ultra-high performance liquid chromatography-tandem mass spectrometry method for the simultaneous determination of iohexol, p-aminohippuric acid (PAH) and exogenously administered creatinine in plasma was develop...
The technique of Solid-Phase Extraction (SPE) is widely used in various fields to concentrate samples and the search for tools to improve recoveries remains of outmost importance. The use of polymer based cartridges has become prevailing in a broad range of fields to enrich peptides from biological matrices. However, the existing SPE protocols are ...
Chemical derivatization allows the introduction of an " ICP-MS accessible" element into pharmaceuticals and their metabolites, thus extending the application range of HPLC-ICP-MS in pharmaceutical applications. In this study, such a pre-column derivatization approach was developed with the aim of using HPLC-ICP-MS for the quantitative metabolite pr...
Objective: To investigate school policies and practices related to drinking fluids and toileting and test their association with children's hydration status and toilet behaviors. Design: Cross-sectional study in 2014. Setting: Seventeen Belgian primary schools. Participants: A total of 416 children (aged 7-13 years). Main Outcome Measures: Hydratio...
Motivation: Data processing is a key bottleneck for 1H NMR-based metabolic profiling of complex biological mixtures, such as biofluids. These spectra typically contain several thousands of signals, corresponding to possibly few hundreds of metabolites. A number of binning-based methods have been proposed to reduce the dimensionality of 1D 1H NMR da...
Morphine (Mop) and methamphetamine (Met) are highly addictive drugs worldwide. Point-of-collection testing (POCT) for drug-of-abuse screening is important in abuse/rehabilitation clinics and law-enforcement agencies. We established an up-converting phosphor technology-based lateral flow assay (UPT-LFA) as a point-of-collection testing (POCT) method...
