Fernández-Delgado, Elena de la Cruz-Martínez, Felipe Galán, Carmen Franco, Lourdes Espino, Javier Viñuelas-Zahínos, Emilio Luna-Giles, Francisco Bejarano, Ignacio
Published in
Journal of inorganic biochemistry
Eluding apoptosis represents the hallmark of tumoral cell behavior. Cisplatin (CisPt) is a very common chemotherapeutic agent to treat cancer by reestablishing apoptotic mechanisms of cell death. However, certain patients acquire resistance to CisPt as well as suffer nephrotoxicity, neurotoxicity, nausea and vomiting. The synthesis of new Pt(II) co...
Mándi, Yvette Endrész, Valéria Mosolygó, Timea Burián, Katalin Lantos, Ildikó Fülöp, Ferenc Szatmári, István Lőrinczi, Bálint Balog, Attila Vécsei, László
...
Published in
Frontiers in immunology
Purpose: The investigation of anti-inflammatory and immunosuppressive functions of Kynurenic acid (KYNA) is now in focus. There is also substantial evidence that TSG-6 has an anti-inflammatory activity. Therefore, in the present study, we compared the effects of newly synthetized KYNA analogs on the TNF-α production in U-937 monocytic cells in corr...
Jafarlou, Mahdi Shanehbandi, Dariush Dehghan, Parvin Mansoori, Behzad Othman, F Baradaran, Behzad
Published in
Artificial cells, nanomedicine, and biotechnology
Acute myeloid leukaemia (AML) is a genetically heterogeneous, severe and rapidly progressing disease triggered by blocking granulocyte or monocyte differentiation and maturation. Overexpression of myeloid cell leukaemia-1 (Mcl-1) and Survivin is associated with drug resistance, tumour progression and inhibition of apoptotic mechanisms in leukaemia ...
Barbasz, Anna Rudolphi-Skórska, Elżbieta Filek, Maria Janeczko, Anna
Published in
Mycotoxin Research
The progressive contamination of food products by mycotoxins such as zearalenone (ZEN) has prompted the search for specific substances that can act as protectors against an accumulation of these toxins. This paper discusses the effect of selenium ions and 24-epibrassinolide (EBR) as non-organic and organic compounds that preserve human lymphoblasti...
Helal, Racha Melzig, Matthias F.
Published in
In Vitro Cellular & Developmental Biology - Animal
The main purpose of this study was to investigate lysozyme synthesis and secretion in three human monocyte cell lines: U-937, HL-60, and THP-1, using sensitive fluorescence-based assay of lysozyme activity. PMA and hIFN-γ were evaluated for inducing lysozyme activity. Using well-defined cell lines from the cell culture collection, no lysozyme activ...
Schmidt, Andreas Johannes Clement, Hans-Willi Gebhardt, Stefan Hemmeter, Ulrich Michael Schulz, Eberhard Krieg, Jürgen-Christian Kircher, Tilo Heiser, Philip
Published in
Journal of Neural Transmission
Oxidative DNA damage as one sign of reactive oxygen species induced oxidative stress is an important factor in the pathogenesis of various psychiatric disorders. Altered levels of DNA base damage products as well as the expression of the main repair enzyme 8-hydroxyguanine glycosylase 1 have been described. The aim of the present study was to exami...
SANTOS, Michel David dos CHEN, Guanjie ALMEIDA, Maria Camila SOARES, Denis Melo SOUZA, Gloria Emilia Petto de LOPES, Norberto Peporine LANTZ, R. Clark
NIH[P50 AT00474]
SANTOS, Michel David dos CHEN, Guanjie ALMEIDA, Maria Camila SOARES, Denis Melo SOUZA, Gloria Emilia Petto de LOPES, Norberto Peporine LANTZ, R. Clark
NIH[P50 AT00474]
SANTOS, Michel David dos CHEN, Guanjie ALMEIDA, Maria Camila SOARES, Denis Melo SOUZA, Gloria Emilia Petto de LOPES, Norberto Peporine LANTZ, R. Clark
NIH[P50 AT00474]
Vyas, Hemant K. Pal, Rahul Vishwakarma, Ram Lohiya, Nirmal K. Talwar, G.P.
Published in
Oncology
Objective: A variety of cancers ectopically express human chorionic gonadotropin beta (hCGβ). Patients harboring such cancers have poor prognosis and adverse survival. A recombinant chimeric antibody, cPiPP, exhibiting high affinity and specificity for hCGβ/hCG was engineered. This study was designed to determine whether this antibody alone or conj...
