Pan, Yue Yang, XueFen Chen, Miaojuan Shi, Kun Lyu, Yuan Meeson, Annette P. Lash, Gendie E.
Published in
Medical Principles and Practice
Ovarian cancer is one of the most common gynecologic malignancies. Recurrence and metastasis often occur after treatment, and it has the highest mortality rate of all gynecological tumors. Cancer stem cells (CSCs) are a small population of cells with the ability of self-renewal, multidirectional differentiation, and infinite proliferation. They hav...
Wang, Wei Zhang, Chenwei Xiong, Meihua Jiang, Lin Fang, Zhiyi Zhou, Hanjian Shao, Yisen
Published in
Applied biochemistry and biotechnology
Wiskott-Aldrich syndrome protein family verprolin-homologous domain-containing protein 3 (WAVE3) is reported as an oncogene regulating cell proliferation and motility in multiple malignancies, while its role in tongue squamous cell carcinoma (TSCC) remains unknown. This study aimed to explore the expression and mechanism of WAVE3 in TSCC. We enroll...
Pradat, Yoann
In the era of extensive data analysis, insights into cancer onset and progression have deepened through molecular analysis of numerous tumors globally. Next-generation sequencing, emerging in the 2000s, transformed cancer cell investigation by enabling exome, transcriptome, and now whole genome profiling. While high-throughput sequencing has not ye...
Muthusamy, Saravanakumar
Published in
Methods in molecular biology (Clifton, N.J.)
We present a simple and quantitative assay system that accurately models human endothelium by use of primary human umbilical vein endothelial cells (HUVECs) in cell culture plates coated with gelatin, a matrix that mimics basal lamina, the matrix that is tightly associated with the vascular endothelium and is critical for its proper function. We de...
Zhong, Wenjing Jian, Yunting Zhang, Chao Li, Yue Yuan, Zhongyu Xiong, Zhenchong Huang, Weiling Ouyang, Ying Chen, Xiangfu Song, Libing
...
Published in
Cancer letters
Triple-negative breast cancer (TNBC) is highly aggressive and metastatic, and has the poorest prognosis among all breast cancer subtypes. Activated β-catenin is enriched in TNBC and involved in Wnt signaling-independent metastasis. However, the underlying mechanisms of β-catenin activation in TNBC remain unknown. Here, we found that SHC4 was upregu...
Wen, Jing Huang, Chunlian Guo, Nina Wang, Wenwen Sheng, Bo
Published in
Case Reports in Oncology
Metastatic malignant lesions of the eyelids are less than 1% of all eyelid tumors. Eyelid metastasis from the cervix, particularly the first sign of metastasis, has not been reported. A female presented to an ophthalmologist with a gradually increasing mass on the lateral edge of the lower eyelid for 2 months and was diagnosed with stage IB1 cervic...
Holme, Jørn A Vondráček, Jan Machala, Miroslav Lagadic-Gossmann, Dominique Vogel, Christoph FA Le Ferrec, Eric Sparfel, Lydie Øvrevik, Johan
Air pollution is the leading cause of lung cancer after tobacco smoking, contributing to 20% of all lung cancer deaths. Increased risk associated with living near trafficked roads, occupational exposure to diesel exhaust, indoor coal combustion and cigarette smoking, suggest that combustion components in ambient fine particulate matter (PM2.5), suc...
Tibbs, Ellis Kandy, Rakhee Rathnam Kalari Jiao, Delong Wu, Long Cao, Xuefang
Published in
Cancer immunology, immunotherapy : CII
Regulatory T cells (Tregs) possess a wide range of mechanisms for immune suppression. Among them, Granzyme B (GzmB) and perforin expressed by Tregs were shown to inhibit tumor clearance in previous reports, which contradicted the canonical roles of these cytotoxic molecules expressed by cytotoxic T cells and NK cells in antitumor immune responses. ...
Pandrangi, Santhi Latha Chittineedi, Prasanthi Mohiddin, Gooty Jaffer Mosquera, Juan Alejandro Neira Llaguno, Sungey Naynee Sánchez
Published in
Journal of cell communication and signaling
Cancer is a cellular impairment disorder characterized by the loss of cell cycle regulation leading to aberrant cell proliferation. Cell-cell communication plays a crucial role in cell signaling which is highly disrupted in various malignancies. Tight junctions (TJs) are major proteins that regulate the proper communication, and the dysregulation o...
Li, Chen Lang, Jiayan Wang, Yazhou Cheng, Zhaoxia Zu, Mali Li, Fenfen Sun, Jingyi Deng, Yating Ji, Tianjiao Nie, Guangjun
...
Published in
Acta pharmaceutica Sinica. B
As a representative chemotherapeutic drug, docetaxel (DTX) has been used for breast cancer treatment for decades. However, the poor solubility of DTX limits its efficacy, and the DTX based therapy increases the metastasis risk due to the upregulation of C-X-C chemokine receptor type 4 (CXCR4) expression during the treatment. Herein, we conjugated C...
