Ofori, Emmanuel Owusu Bin Alhassan, Baba Alhaji Ayabilah, Edwina Ayaaba Maison, Patrick Opoku Manu Asante-Asamani, Alvin Atawura, Henry Rahman, Ganiyu Adebisi Akakpo, Patrick Kafui Imbeah, Emmanuel Gustav Ofori, Prince Wilson
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Published in
African Journal of Urology
BackgroundRenal cell carcinoma (RCC) is a heterogeneous group of malignant epithelial tumors of the kidney. It accounts for more than 90% of all kidney cancers. However, papillary RCC is the second most common histologic subtype representing 10–15% of all RCCs. The mean age of presentation for papillary RCC ranges between 59 and 63 years but more i...
Wu, Qi Li, Bei Li, Juanjuan Sun, Si Yuan, Jingping Sun, Shengrong
Published in
Biomarker Research
Cancer-associated adipocytes (CAAs), as a main component of the tumor-adipose microenvironment (TAME), have various functions, including remodeling the extracellular matrix and interacting with tumor cells or infiltrated leukocytes through a variety of mutual signals. Here, we summarize the primary interplay among CAAs, the immune response and canc...
Nam, Heerim Lim, Do Hoon Kim, Jae J Lee, Jun Haeng Min, Byung-Hoon Lee, Hyuk
Published in
Cancers
This study aimed to evaluate the clinical outcomes of radiation therapy (RT) for stage I gastric mucosa-associated lymphoid tissue (MALT) lymphoma and find predictive factors for relapse after RT. This retrospective study included 145 patients without a prior history of treatment, except Helicobacter pylori eradication therapy, who were irradiated ...
Rankin, Andrew Johnson, Adrienne Roos, Alison Kannan, Geoffrey Knipstein, Jeffrey Britt, Nicholas Rosenzweig, Mark Haberberger, James Pavlick, Dean Severson, Eric
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Published in
The oncologist
RAF family protein kinases signal through the MAPK pathway to orchestrate cellular proliferation, survival, and transformation. Identifying BRAF alterations in pediatric cancers is critically important as therapeutic agents targeting BRAF or MEK may be incorporated into the clinical management of these patients. In this study, we performed comprehe...
Zhang, Xuran Ruan, Qing Jiang, Yuhao Gan, Qianqian Zhang, Junbo
Published in
Translational oncology
Previously, we reported a [99mTc(ǀ)]+ labeled d-glucoamine derivative (99mTc-CN5DG) and evaluated it as a tumor imaging agent in mice bearing A549 tumor xenografts. In this paper, 99mTc-CN5DG was further studied in U87 MG (human glioma cells), HCT-116 (human colon cancer cells), PANC-1 (human pancreatic cancer cells) and TE-1 (human esophageal canc...
Guo, Yuexin Wang, Boya Wang, Tiantian Gao, Lei Yang, Ze-jun Wang, Fei-fei Shang, Hong-wei Hua, Rongxuan Xu, Jing-dong
Published in
International Journal of Biological Sciences
The intestine serves as an important digestive and the largest immune organ in the body. Interleukin-6(IL-6), an important mediator of various pathways, participates in the interactions between different kinds of cells and closely correlates with intestinal physiological and pathological condition. In this review we summarize the signaling pathways...
Moloudizargari, Milad Moradkhani, Fatemeh Hekmatirad, Shirin Fallah, Marjan Asghari, Mohammad Hossein Reiter, Russel J
Published in
Life sciences
The biological functions of melatonin range beyond the regulation of the circadian rhythm. With regard to cancer, melatonin's potential to suppress cancer initiation, progression, angiogenesis and metastasis as well as sensitizing malignant cells to conventional chemo- and radiotherapy are among its most interesting effects. The targets at which me...
Zhang, Yang Shi, Xiao-Jun Zhang, Xian-Cui Zhao, Xing-Jie Li, Jun-Xiang Wang, Lin-Heng Xie, Chun-E Liu, Yu-Yue Wang, Yun-Liang
Published in
World Journal of Clinical Cases
BACKGROUND Primary duodenal tuberculosis is very rare. Due to a lack of specificity for its presenting symptoms, it is easily misdiagnosed clinically. Review of the few case reports and literature on the topic will help to improve the overall understanding of this disease and aid in differential diagnosis to improve patient outcome. CASE SUMMARY A ...
WANG, Yutong YE, Fan ZHANG, Xiao ZOU, Ruihan WANG, Mingyuan YU, Kai CUI, Shiyun
Published in
Chinese Journal of Lung Cancer
染色体外DNA（extrachromosomal DNA, ecDNA）是位于染色体外的小片段环状DNA，具有自我复制功能。已有研究证明癌基因在ecDNA上被扩增是肿瘤细胞中的常见现象，并且具有一些值得研究的特征，如与患者的不良预后相关。多种染色体事件参与ecDNA形成，且它的扩增能直接使染色体外癌基因DNA拷贝数增加，加速肿瘤产生和发展。并且，亲代ecDNA细胞不均等传递到子代的分离方式，不仅增加肿瘤异质性，同时增强肿瘤对环境的适应和对治疗的反应能力。本文对ecDNA在肿瘤细胞中的研究现状及其潜在意义作一综述。
Chen, Fei Su, Run Ni, Shiwei Liu, Yan Huang, Jiexiang Li, Gege Wang, Qun Zhang, Xi Yang, Yufeng
Published in
Redox Biology
Reactive oxygen species (ROS) contribute to cellular redox environment and serve as signaling molecules. Excessive ROS can lead to oxidative stress that are involved in a broad spectrum of physiological and pathological conditions. Stem cells have unique ROS regulation while cancer cells frequently show a constitutive oxidative stress that is assoc...
