Hojat, Ali Jeibouei, Shabnam Aref, Amir Reza Kalbasi, Alireza Moghaddam, Maryam Mohammadi, Farzaneh Javadi, Seyed Mohammadreza Ajoudanian, Mohammad Sharifi, Kazem Zali, Hakimeh
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Published in
Iranian journal of pharmaceutical research : IJPR
Surgery is the standard treatment for breast malignancies, although local and distant relapses might occur. Previous studies have shown that surgery-induced wound fluid (WF) contains tumor-initiating and progressing factors; however, these experiments have only been performed on breast cancer cell lines. Since a cancerous tumor includes various com...
González-López, Pablo Martorell-Llobregat, Carlos Beneš, Vladimír Daniel, Roy T
Published in
Acta neurochirurgica
Facial nerve schwannomas can extend to the middle fossa or the cerebellopontine angle through the labyrinthine and cisternal segments of the facial nerve. The middle fossa approach (MFA) and its extensions provide a wide approach to deal with a large variety of lesions located in the middle and posterior cranial fossa junction. We describe the MFA ...
Tsimberidou, Apostolia M Fountzilas, Elena Bleris, Leonidas Kurzrock, Razelle
Transcriptomics, which encompasses assessments of alternative splicing and alternative polyadenylation, identification of fusion transcripts, explorations of noncoding RNAs, transcript annotation, and discovery of novel transcripts, is a valuable tool for understanding cancer mechanisms and identifying biomarkers. Recent advances in high-throughput...
Morales-Martínez, Mario Vega, Mario I
miRNAs are non-coding RNA sequences of approximately 22 nucleotides that interact with genes by inhibiting their translation through binding to their 3' or 5' UTR regions. Following their discovery, the role they play in the development of various pathologies, particularly cancer, has been studied. In this context, miR-7 is described as an importan...
Yuzhalin, Arseniy E
Published in
Seminars in cell & developmental biology
Interaction of a tumor with its microenvironment is an emerging field of investigation, and the crosstalk between cancer cells and the extracellular matrix is of particular interest, since cancer patients with abundant and stiff extracellular matrices display a poorer prognosis. At the post-juvenile stage, the extracellular matrix plays predominant...
Umeh-Garcia, Maxine O'Geen, Henriette Simion, Catalina Gephart, Melanie Hayden Segal, David J Sweeney, Colleen A
BackgroundLRIG1, the founding member of the LRIG (leucine-rich repeat and immunoglobulin-like domain) family of transmembrane proteins, is a negative regulator of receptor tyrosine kinases and a tumour suppressor. Decreased LRIG1 expression is consistently observed in cancer, across diverse tumour types, and is linked to poor patient prognosis. How...
Stern, Lawrence A Gholamin, Sharareh Moraga, Ignacio Yang, Xin Saravanakumar, Supraja Cohen, Joseph R Starr, Renate Aguilar, Brenda Salvary, Vanessa Hibbard, Jonathan C
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IL13Rα2 is an attractive target due to its overexpression in a variety of cancers and rare expression in healthy tissue, motivating expansion of interleukin 13 (IL13)-based chimeric antigen receptor (CAR) T cell therapy from glioblastoma into systemic malignancies. IL13Rα1, the other binding partner of IL13, is ubiquitously expressed in healthy tis...
Dar, Altaf A Bezrookove, Vladimir Nosrati, Mehdi Ice, Ryan Patino, John M Vaquero, Edith M Parrett, Brian Leong, Stanley P Kim, Kevin B Debs, Robert J
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Therapy of BRAF-mutant melanoma with selective inhibitors of BRAF (BRAFi) and MEK (MEKi) represents a major clinical advance but acquired resistance to therapy has emerged as a key obstacle. To date, no clinical approaches successfully resensitize to BRAF/MEK inhibition. Here, we develop a therapeutic strategy for melanoma using bromosporine, a bro...
Shimabukuro, Wataru Hamada, Satoru Oshiro, Tokiko Nakada, Shougo Hyakuna, Nobuyuki Nakanishi, Koichi
Published in
Pediatric nephrology (Berlin, Germany)
In pediatric cancer patients, the estimated glomerular filtration rate based on serum cystatin C (CysC) was reported to be suitable for estimating kidney function because of low serum creatinine (Cr) and high serum β2-microglobulin. Recently, however, serum CysC levels have been reported to be elevated in some cancer patients other than those with ...
Solomon, Paige E Kirkemo, Lisa L Wilson, Gary M Leung, Kevin K Almond, Mark H Sayles, Leanne C Sweet-Cordero, E Alejandro Rosenberg, Oren S Coon, Joshua J Wells, James A
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Since the discovery of oncogenes, there has been tremendous interest to understand their mechanistic basis and to develop broadly actionable therapeutics. Some of the most frequently activated oncogenes driving diverse cancers are c-MYC, EGFR, HER2, AKT, KRAS, BRAF, and MEK. Using a reductionist approach, we explored how cellular proteomes are remo...
