Taddio, Marco Doshi, Suraj Masri, Marwan Jeanjean, Pauline Hikmat, Firas Gerlach, Alana Nyiranshuti, Lea Rosser, Ethan Schaue, Dorthe Besserer-Offroy, Elie
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PURPOSE: Fibroblast Activation Protein (FAP) is an emerging theranostic target that is highly expressed on cancer-associated fibroblasts and on certain tumor cells including sarcoma. We investigated the anti-tumor efficacy of [225Ac]Ac-FAPI-46 as monotherapy or in combination with immune checkpoint blockade (ICB) in immunocompetent murine models of...
Roychowdhury, Tanaya McNutt, Seth Pasala, Chiranjeevi Nguyen, Hieu Thornton, Daniel Sharma, Sahil Botticelli, Luke Digwal, Chander Joshi, Suhasini Yang, Nan
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The intricate network of protein-chaperone interactions is crucial for maintaining cellular function. Recent discoveries have unveiled the existence of specialized chaperone assemblies, known as epichaperomes, which serve as scaffolding platforms that orchestrate the reconfiguration of protein-protein interaction networks, thereby enhancing cellula...
Yang, Yatian Zhang, Xiong Cai, Demin Zheng, Xingling Zhao, Xuan Zou, June X Zhang, Jin Borowsky, Alexander D Dall’Era, Marc A Corey, Eva
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Profound functional switch of key regulatory factors may play a major role in homeostasis and disease. Dysregulation of circadian rhythm (CR) is strongly implicated in cancer with mechanisms poorly understood. We report here that the function of REV-ERBα, a major CR regulator of the orphan nuclear receptor subfamily, is dramatically altered in tumo...
Liu, S Zou, Christopher Pak, Joanna Morse, Alexandra Pang, Dillon Casey-Clyde, Timothy Borah, Ashir Wu, David Seo, Kyounghee OLoughlin, Thomas
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BACKGROUND: Genetic perturbation screens with single-cell readouts have enabled rich phenotyping of gene function and regulatory networks. These approaches have been challenging in vivo, especially in adult disease models such as cancer, which include mixtures of malignant and microenvironment cells. Glioblastoma (GBM) is a fatal cancer, and method...
Wang, Justin Landry, Alexander Raleigh, David Sahm, Felix Walsh, Kyle Goldbrunner, Roland Yefet, Leeor Tonn, Jörg Gui, Chloe Ostrom, Quinn
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Meningiomas are the most common primary intracranial tumors in adults and are increasing in incidence due to the aging population and increased access to neuroimaging. While most exhibit nonmalignant behavior, a subset of meningiomas are biologically aggressive and are associated with treatment resistance, resulting in significant neurologic morbid...
Botta, Gregory Abdelrahim, Maen Drengler, Ronald Aushev, Vasily Esmail, Abdullah Laliotis, George Brewer, Chris George, Giby Abbate, Steven Chandana, Sreenivasa
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INTRODUCTION: Personalized and tumor-informed circulating tumor DNA (ctDNA) testing is feasible and allows for molecular residual disease (MRD) identification in patients with pancreatic ductal adenocarcinoma (PDAC). METHODS: In this retrospective analysis of commercial cases from multiple US institutions, personalized, tumor-informed, whole-exome ...
Do, Annie Magesh, Shruti Uzelac, Matthew Chen, Tianyi Li, Wei Bouvet, Michael Brumund, Kevin Wang-Rodriguez, Jessica Ongkeko, Weg
Transfer-RNA-derived fragments (tRFs) are a novel class of small non-coding RNAs that have been implicated in oncogenesis. tRFs may act as post-transcriptional regulators by recruiting AGO proteins and binding to highly complementary regions of mRNA at seed regions, resulting in the knockdown of the transcript. Therefore, tRFs may be critical to tu...
Hillis, Alissandra Martin, Timothy Manchester, Haley Högström, Jenny Zhang, Na Lecky, Emmalyn Kozlova, Nina Lee, Jonah Persky, Nicole Root, David
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Triple-negative breast cancer (TNBC) is responsible for a disproportionate number of breast cancer patient deaths due to extensive molecular heterogeneity, high recurrence rates, and lack of targeted therapies. Dysregulation of the phosphoinositide 3-kinase (PI3K)/AKT pathway occurs in approximately 50% of TNBC patients. Here, we performed a genome...
Yeh, Christine Yiwen Aguirre, Karmen Laveroni, Olivia Kim, Subin Wang, Aihui Liang, Brooke Zhang, Xiaoming Han, Lucy M Valbuena, Raeline Bassik, Michael C
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The drivers of immune evasion are not entirely clear, limiting the success of cancer immunotherapies. Here we applied single-cell spatial and perturbational transcriptomics to delineate immune evasion in high-grade serous tubo-ovarian cancer. To this end, we first mapped the spatial organization of high-grade serous tubo-ovarian cancer by profiling...
García García, Omar Ortiz, Ramon Moreno-Barbosa, Eduardo D-Kondo, Naoki Faddegon, Bruce Ramos-Méndez, Jose
This work aims to develop and validate a framework for the multiscale simulation of the biological response to ionizing radiation in a population of cells forming a tissue. We present TOPAS-Tissue, a framework to allow coupling two Monte Carlo (MC) codes: TOPAS with the TOPAS-nBio extension, capable of handling the track-structure simulation and su...