Vivekanandan, Monika M Adankwah, Ernest Aniagyei, Wilfred Acheampong, Isaac Yeboah, Augustine Arthur, Joseph F Lamptey, Millicent N K Abass, Mohammed K Gawusu, Amidu Kumbel, Francis
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Published in
Infection
Mycobacterium (M.) tuberculosis-caused immunopathology is characterized by aberrant expression of plasma cytokines in human tuberculosis. Disease severity and long-term anti-mycobacterial treatment are potentially influenced by immunopathology and normalization of plasma cytokine levels during therapy may indicate treatment efficacy and recovery. I...
Smock, Laura Nguyen, Thinh Gadani, Kavita Tibbs, Andrew Geltman, Paul L Bernardo, John Cochran, Jennifer
Published in
Journal of immigrant and minority health
Refugees and immigrants undergo tuberculosis screening prior to arrival in the United States. CDC Technical Instructions for screening changed in 2007. Our goal was to quantify TB disease in refugees after 2007 and identify risks for disease. Massachusetts refugee and tuberculosis databases were matched to identify refugees who arrived 2008-2017 an...
Nyirenda, John L Z Bockey, Annabelle Wagner, Dirk Lange, Berit
Published in
Pathogens and global health
A systematic review (Prospero CRD42017075562) including articles published between 1 January 1990 and 31 October 2021 was performed to synthesize evidence on the effect of integrating tuberculosis (TB) and diabetes mellitus (DM) healthcare on screening coverage and treatment loss to follow-up as compared to non-integrated care services for TB and D...
González-Gordo, Salvador Palma, José M Corpas, Francisco J
Published in
Plants (Basel, Switzerland)
Small heat shock proteins (sHSPs) are usually upregulated in plants under diverse environmental stresses. These proteins have been suggested to function as molecular chaperones to safeguard other proteins from stress-induced damage. The ripening of pepper (Capsicum annuum L.) fruit involves important phenotypic, physiological, and biochemical chang...
Paz, Josiane Delgado Denise de Moura Sperotto, Nathalia Ramos, Alessandro Silva Pissinate, Kenia da Silva Rodrigues Junior, Valnês Abbadi, Bruno Lopes Borsoi, Ana Flávia Rambo, Raoní Scheibler Corso Minotto, Ana Carolina da Silva Dadda, Adilio
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Published in
European journal of medicinal chemistry
Herein a series of 4-aminoquinolines were synthesized in an attempt to optimize and study the structural features related to LABIO-17 biological activity, a Mycobacterium tuberculosis NADH-dependent enoyl-acyl carrier protein reductase (MtInhA) inhibitor previously identified by a virtual-ligand-screening approach. Structure-activity relationships ...
Krishnan, Sowmya Ramaswamy Bung, Navneet Padhi, Siladitya Bulusu, Gopalakrishnan Misra, Parimal Pal, Manojit Oruganti, Srinivas Srinivasan, Rajgopal Roy, Arijit
Published in
Journal of molecular graphics & modelling
Mycobacterium tuberculosis (Mtb) is a pathogen of major concern due to its ability to withstand both first- and second-line antibiotics, leading to drug resistance. Thus, there is a critical need for identification of novel anti-tuberculosis agents targeting Mtb-specific proteins. The ceaseless search for novel antimicrobial agents to combat drug-r...
León Rubio, Isabel Espejo, Guerrero
Published in
Reumatologia clinica
osteoarticular tuberculosis represents 2%-5% of the manifestations of tuberculosis. The objective was to calculate the incidence and describe the epidemiological characteristics of patients with osteoarticular tuberculosis who received hospital care in Spain between 1997-2018. A retrospective study was conducted of patients treated with osteoarticu...
Jiang, Jing Cao, Zhihong Xiao, Li Li, Binyu Yu, Shan Yang, Bingfen Liu, Yanhua Zhai, Fei Wang, Ruo Cheng, Xiaoxing
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Published in
Microbes and infection
Tissue-resident MAIT cells in tuberculous pleural effusions, the site of tuberculosis infection, were investigated in the study. Tim-3+CD69+CD103+ and CD39+CD69+CD103+ tissue-resident MAIT cell subsets were identified in tuberculous pleural effusions. Tim-3 expression in MAIT cells was greatly induced and CD39 expression was elevated following ex v...
Bedoya, Óscar Guarín Aristizábal, Harry Santiago Agudelo, Jared
Tuberculosis is a respiratory disease that affects lungs and it is caused by the bacillus Mycobacterium tuberculosis (MTB), which is spread when people who are sick with tuberculosis expel bacteria into the air by coughing. Before the coronavirus (COVID-19) pandemic, tuberculosis was the leading cause of death from infectious agents even ranking ab...
Günther, Gunar Guglielmetti, Lorenzo Leu, Claude Lange, Christoph van Leth, Frank
Published in
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
To evaluate the access to comprehensive diagnostics and novel antituberculosis medicines in European countries. We investigated the access to genotypic and phenotypic Mycobacterium tuberculosis drug susceptibility testing and the availability of antituberculosis drugs and calculated the cost of drugs and treatment regimens at major tuberculosis tre...
