Rayford, Kayla J. Cooley, Ayorinde Strode, Anthony W. Osi, Inmar Arun, Ashutosh Lima, Maria F. Misra, Smita Pratap, Siddharth Nde, Pius N.
Published in
Frontiers in Cellular and Infection Microbiology
Trypanosoma cruzi, the etiological agent of Chagas Disease, causes severe morbidity, mortality, and economic burden worldwide. Though originally endemic to Central and South America, globalization has led to increased parasite presence in most industrialized countries. About 40% of infected individuals will develop cardiovascular, neurological, and...
Martínez-Ibarra, José Alejandro Nogueda-Torres, Benjamín Montañez-Valdez, Oziel Dante Michel-Parra, J Guadalupe
Published in
Medical and veterinary entomology
Chagas disease is one of the most important vector-borne diseases in Latin America, including Mexico. Triatoma pallidipennis (Stål) (Hemiptera: Reduviidae) is a Mexican triatomine vector commonly associated with different hosts. The influence of six blood meals (rabbits, rats, mice, dogs, cats and chickens) on six biological parameters of the biolo...
Biscari, Lucía Maza, Ma Carmen Farré, Cecilia Kaufman, Cintia Daniela Amigorena, Sebastian Fresno, Manuel Gironès, Núria Alloatti, Andrés
Published in
Frontiers in Cell and Developmental Biology
Antigen cross-presentation is a vital mechanism of dendritic cells and other antigen presenting cells to orchestrate the priming of cytotoxic responses towards killing of infected or cancer cells. In this process, exogenous antigens are internalized by dendritic cells, processed, loaded onto MHC class I molecules and presented to CD8+ T cells to ac...
Ramírez-Olivencia, Germán Arsuaga, Marta Torrús, Diego Belhassen-Garcia, Moncef Rodríguez-Guardado, Azucena Herrero-Mendoza, María Dolores Mateo-Maestre, María Campos-Rivas, Ramiro P Novales, Francisco J Membrillo-de
Published in
Revista clinica espanola
Chagas disease (CD) is a parasitic disease caused by Trypanosoma cruzi, in which up to 10-20% of those affected may suffer digestive disorders. Multiple studies have been carried out on CD in non-endemic countries, mainly related to cardiological involvement. However, digestive disorders have not been analyzed in such depth. The objective of the st...
Jones, Kathryn M. Mangin, Elise N. Reynolds, Corey L. Villanueva, Liliana E. Cruz, Julio Vladimir Versteeg, Leroy Keegan, Brian Kendricks, April Pollet, Jeroen Gusovsky, Fabian
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Published in
Frontiers in Cellular and Infection Microbiology
Introduction Chagas disease, caused by chronic infection with the protozoan parasite Trypanosoma cruzi, affects 6-7 million people worldwide. The major clinical manifestation of Chagas disease is chronic Chagasic cardiomyopathy (CCC), which encompasses a spectrum of symptoms including arrhythmias, hypertrophy, dilated cardiomyopathy, heart failure,...
Venturini, Gabriela Alvim, Juliana M. Padilha, Kallyandra Toepfer, Christopher N. Gorham, Joshua M. Wasson, Lauren K. Biagi, Diogo Schenkman, Sergio Carvalho, Valdemir M. Salgueiro, Jessica S.
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Published in
Frontiers in Cellular and Infection Microbiology
Introduction Chagas cardiomyopathy, a disease caused by Trypanosoma cruzi (T. cruzi) infection, is a major contributor to heart failure in Latin America. There are significant gaps in our understanding of the mechanism for infection of human cardiomyocytes, the pathways activated during the acute phase of the disease, and the molecular changes that...
Barnadas-Carceller, Berta Martinez-Peinado, Nieves Gómez, Laura Córdoba Ros-Lucas, Albert Gabaldón-Figueira, Juan Carlos Diaz-Mochon, Juan J. Gascon, Joaquim Molina, Ignacio J. Pineda de las Infantas y Villatoro, Marí... Alonso-Padilla, Julio
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Published in
Frontiers in Cellular and Infection Microbiology
Introduction Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, and it is the most important neglected tropical disease in the Americas. Two drugs are available to treat the infection, but their efficacy in the chronic stage of the disease, when most cases are diagnosed, is reduced. Their tolerability is also hindered by common a...
González-Herrera, Fabiola Clayton, Natasha S. Guzmán-Rivera, Daniela Carrillo, Ileana Castillo, Christian Catalán, Mabel Anfossi, Renatto Quintero-Pertuz, Helena Quilaqueo, María Elena Olea-Azar, Claudio
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Published in
Frontiers in Immunology
Introduction Chronic Chagasic cardiomyopathy (CCC), caused by the protozoan Trypanosoma cruzi, is the most severe manifestation of Chagas disease.CCC is characterized by cardiac inflammation and fibrosis caused by a persistent inflammatory response. Following infection, macrophages secrete inflammatory mediators such as IL-1β, IL-6, and TNF-α to co...
Puerta, Concepción J. Cuellar, Adriana Lasso, Paola Mateus, Jose Gonzalez, John M.
Published in
Frontiers in Cellular and Infection Microbiology
Trypanosoma cruzi, the causal agent of Chagas disease, has coexisted with humans for thousands of years. Therefore, the parasite has developed several mechanisms of antigenic variability that has allowed it to live inside the cells and evade the host immune response. Since T. cruzi displays an intracellular cycle-stage, our research team focused on...
Ramírez López, Laura Ximena Monroy Díaz, Ángela Liliana Rodríguez Niño, Sonia Bonilla Arévalo, Danna Gabriela Suescún Carrero, Sandra Helena
Introduction: The use of measurement tools to obtain information about knowledge, attitudes and practices of various diseases are widely used, since they allow to collect clear and detailed information of every aspect needing examination. Objective: Determine knowledge, attitudes and practices regarding Chagas disease in an endemic zone in Boyacá, ...
