For more than 2000 years, artists have exploited cast shadows to influence how objects appear to be positioned in a scene. A contact cast shadow can anchor an object to the ground and a detached cast shadow can make an object appear to float. However, there is a period of approximately 1000 years when there were virtually no cast shadows in art. Ho...
Published in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry
In this study, a simple and sensitive colorimetric method for penconazole sensing is reported. It is based on the etching/anti-etching strategy in which gold nanostar@graphene quantum dot (AuNS@GQD) nanocomposite acts as a sensing nanoprobe and IO4- as an etching agent. With adding IO4- to the solution of AuNSs@GQDs, the sharp tips of NSs are etche...
Published in Chemotherapy
Background: Acute myeloid leukemia (AML) is a life-threatening disease whose treatment is made difficult by a number of mutations or receptor overexpression in the proliferating cellular clones. Life expectancy of patients diagnosed with new, relapsed-refractory, or secondary AML has been improved by drugs targeted at such moieties. Regrettably, ho...
Published in Journal of biomolecular structure & dynamics
In this work, eight new 1,2,3-triazoles (6a-h) were synthesized from acetylenes' "click" reaction with p-substituted azide derivatives. The structures of the compounds were characterized using standard analytical and spectroscopic methods (elemental analysis, FT-IR, 1H(13C)NMR). The anticancer, antioxidant, α-amylase, ADME, molecular docking studie...
Published in The Science of the total environment
Food safety problems caused by pesticide residues have always been a concern for many people. In this study, we investigated the uptake, translocation and subcellular distribution of neonicotinoid insecticides, triazole fungicides, and sulfonylurea herbicides in rice plants (Oryza sativa L.). The time-dependent uptake kinetics of the three categori...
The present review narrates several reports which deal with the synthesis of fused 1,2,3-triazole containing scaffolds following a sequential multicomponent reaction (MCR)-intramolecular azide-alkyne cycloaddition (IAAC) approach. The reviewed reactions were cleverly designed so as to incorporate azide and alkyne functionalities in the MCR product ...
A series of novel 1,2,3-triazole-linked ciprofloxacin-chalcones 4a-j were synthesised as potential anticancer agents. Hybrids 4a-j exhibited remarkable anti-proliferative activity against colon cancer cells. Compounds 4a-j displayed IC50s ranged from 2.53-8.67 µM, 8.67-62.47 µM, and 4.19-24.37 µM for HCT116, HT29, and Caco-2 cells; respectively, wh...
ABSTRACT - The current paper evaluated the incubation time, and doses of Uniconazole (UCZ) applied to maize seeds to verify the plants? response at different phenological stages. MSG1001 hybrid seeds were treated with UCZ (0, 50, and 100 mg.kg-1 of seed) with different incubation times (IT ? 1 min and 12 h). In the lab experiment, the treated seeds...
The negative impact of human activities on the ecosystem is significant. Environmentally oriented studies in multidisciplinary approaches are needed to better understand and limit this impact. One of the major issues is the development of antimicrobial resistance, of which one example is the resistance of Aspergillus fumigatus to triazoles. This ub...
Published in Pharmacological research
The compromised viability and function of cardiovascular cells are rescued by small molecules of triazole derivatives (Tzs), identified as 3a and 3b, by preventing mitochondrial dysfunction. The oxidative phosphorylation improves the respiratory control rate in the presence of Tzs independently of the substrates that energize the mitochondria. The ...
