Kumar, Prashant Kinger, Sumit Dubey, Ankur Rakesh Jagtap, Yuvraj Anandrao Choudhary, Akash Prasad, Amit Jha, Hem Chandra Dhiman, Rohan Gutti, Ravi Kumar Mishra, Amit
...
Published in
Molecular neurobiology
Accumulation of misfolded proteins compromises overall cellular health and fitness. The failure to remove misfolded proteins is a critical reason for their unwanted aggregation in dense cellular protein pools. The accumulation of various inclusions serves as a clinical feature for neurodegenerative diseases. Previous findings suggest that different...
BARROS, J. R. A. GUIMARÃES, M. J. M. SILVA, R. L. de O. SILVA, J. B. da BARROS, A. A. G. de ANGELOTTI, F. MELO, N. F. de
Plants exposed to adverse environmental conditions develop molecular mechanisms of adaptation and/or defense, the osmoprotectors, which function as compatible solutes and contribute to tolerance via prevention systems and protection against cellular damage caused by these abiotic stresses. This study aimed to identify and characterize the osmoprote...
MADI, Charbel HSEIN, Hassana BUSIGNIES, Virginie TCHORELOFF, Pierre MAZEL, Vincent
Most of biopharmaceuticals, in their liquid form, are prone to instabilities during storage. In order to improve their stability, lyophilization is the most commonly used drying technique in the pharmaceutical industry. In addition, certain applications of biopharmaceutical products can be considered by oral administration and tablets are the most ...
Huang, Zheping Cheng, Shibin Jash, Sukanta Fierce, Jamie Agudelo, Anthony Higashiyama, Takanobu Hanna, Nazeeh Nakashima, Akitoshi Saito, Shigeru Schuster, Jessica
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The etiology of preeclampsia (PE), a severe complication of pregnancy with several clinical manifestations and a high incidence of maternal and fetal morbidity and mortality, remains unclear. This issue is a major hurdle for effective treatment strategies. We recently demonstrated that PE exhibits an Alzheimer-like etiology of impaired autophagy an...
Cao, Yu Gao, Cai Yang, Lei Zhou, Pei Sun, Dongfang
Published in
Cryobiology
Trehalose is widely acknowledged for its ability to stabilize plasma membranes during dehydration. However, the exact mechanism by which trehalose interacts with lipid bilayers remains presently unclear. In this study, we conducted atomistic molecular dynamic simulations on asymmetric model bilayers that mimic the membrane of human red blood cells ...
Luo, Xiongwei; Jiang, Lei; Zhao, Rui; Wang, Yue; 144633; Xiao, Xin; Ghazouani, Sabrine; Yu, Lihua; Mai, Zhaohuan; Matsuyama, Hideto; Jin, Pengrui; 126855;
...
Recovery of water, salts, and hazardous dye from complex saline textile wastewater faces obstacles in separating dissolved ionic substances and recovering organic components during desalination. This study realized the simultaneous fractionation, desalination, and dye removal/recovery treatment of textile wastewater by using trehalose (Tre) as an a...
Wang, Shengnan Chen, Youfang Wu, Chunchun Wang, Yaoguo Lin, Weiqiang Bu, Rongsheng
Published in
Applied biochemistry and biotechnology
Myocardial ischemia/reperfusion (I/R) injury is a pathological damage secondary to myocardial ischemia that can further aggravate tissue and organ injuries. Therefore, there is an urgent need to develop an effective approach for alleviating myocardial I/R injury. Trehalose (TRE) is a natural bioactive substance that has been shown to have extensive...
Naiini, Mahdis Rahimi Shahouzehi, Beydolah Azizi, Shahrzad Shafiei, Bentolhoda Nazari-Robati, Mahdieh
Published in
Naunyn-Schmiedeberg's archives of pharmacology
Aging is associated with a disturbance in the regulation of the metabolic function of the liver, which increases the risk of liver and systemic diseases. Trehalose, a natural disaccharide, has been identified to reduce dyslipidemia, hepatic steatosis, and glucose intolerance. However, the roles of trehalose on lipid metabolism in aged liver are unc...
Lutta, Anitta Knopp, Matthias M Tollemeto, Matteo Pedersen, Gabriel K Schmidt, Signe T Grohganz, Holger Hagner Nielsen, Line
Published in
International journal of pharmaceutics
Successful oral delivery of liposomes requires formulations designed to withstand harsh gastrointestinal conditions, e.g., by converting to solid-state followed by loading into gastro-resistant delivery devices. The hypothesis was that the use of dextran-trehalose mixtures for spray drying would improve the rehydration kinetics of dried liposomes. ...
Madi, Charbel Hsein, Hassana Busignies, Virginie Tchoreloff, Pierre Mazel, Vincent
Most of biopharmaceuticals, in their liquid form, are prone to instabilities during storage. In order to improve their stability, lyophilization is the most commonly used drying technique in the pharmaceutical industry. In addition, certain applications of biopharmaceutical products can be considered by oral administration and tablets are the most ...
