Papa, Francesca Grinda, Thomas Rassy, Elie Cheickh-Hussin, Rasha Ribeiro, Joana Antonuzzo, Lorenzo Pistilli, Barbara
Breast cancer is a heterogeneous disease, encompassing multiple different subtypes. Thanks to the increasing knowledge of the diverse biological features of each subtype, most patients receive personalized treatment based on known biomarkers. However, the role of some biomarkers in breast cancer evolution is still unknown, and their potential use a...
Melzer-Ribeiro, D L Napolitano, I C Leite, S A Alencar de Souza, J A Vizzotto, A D B Di Sarno, E S Fortes, M Gomes, M L de Oliveira, G M Avrichir, B S
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Published in
Schizophrenia research
There is no established treatment for patients with clozapine-resistant schizophrenia (CRS). Clozapine augmentation strategies with antipsychotics or others substances are effective in comparison with placebo while and Electroconvulsive therapy (ECT) showed to be effective in comparison with treatment as usual (TAU) but not with placebo (sham-ECT)....
Fava, Giovanni A.
Published in
Psychotherapy and Psychosomatics
Pradat, Yoann
In the era of extensive data analysis, insights into cancer onset and progression have deepened through molecular analysis of numerous tumors globally. Next-generation sequencing, emerging in the 2000s, transformed cancer cell investigation by enabling exome, transcriptome, and now whole genome profiling. While high-throughput sequencing has not ye...
Tuo, Karim Beourou, Sylvain Assi, Serge-Brice Sanogo, Ibrahima Jambou, Ronan
Background Decreased efficacy of artemisinin-based combination therapy (ACT) for Plasmodium falciparum malaria has been previously reported in patients with sickle cell disease (SCD). The main purpose of this study was to investigate the in vitro susceptibility of isolates to dihydro-artemisinin (DHA) to provide a hypothesis to explain this treatme...
Shi, Jingman Chen, Yan Jiang, Yingchen Li, Yanzhi Wang, Wanxin Zhao, Hao Guo, Lan Liao, Yuhua Zhang, Huimin Gao, Caihong
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This study sought to evaluate internalized stigma (IS) and perceived stigma (PS), in persons (n = 522) living with major depressive disorder (MDD), with a view to analyzing the association of IS and PS with medication adherence in a cohort of participants with MDD in China. Perceived stigma is the awareness of societal negative views and attitudes ...
Brooks, Samantha Dahl, K. Dudley-Jones, R. Schiöth, Helgi
Anorexia nervosa (AN) is an eating disorder often highly resistant to treatment, characterised by restrictive eating and/or compensatory behaviours such as purging or excessive exercising, leading to low body weight and dysregulated appetite. The recovery rate is low for those with AN in standard treatment, including cognitive behavioural therapy (...
Daniels, Scott D Boison, Detlev
Published in
Neuropharmacology
Decreased ATPergic signaling is an increasingly recognized pathophysiology in bipolar mania disease models. In parallel, adenosine deficit is increasingly recognized in epilepsy pathophysiology. Under-recognized ATP and/or adenosine-increasing mechanisms of several antimanic and antiseizure therapies including lithium, valproate, carbamazepine, and...
Stahl, Stephen M Djokic, Gorica
Published in
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
In this paper, we will discuss the pharmacologic properties of antipsychotics, including those that are the same in structure and those that differentiate one from another. We will bring to you how differential pharmacologic properties can explain differential efficacy and differential tolerability. We will review how to use plasma drug levels and ...
Liu, Yu Da, Mingxu
Published in
Journal of cancer research and clinical oncology
Wilms tumor 1 associated protein (WTAP) is a key RNA n6-methyladenosine (m6A) methylase, which predicts the occurrence of many diseases, such as liver fibrosis formation, coordinating cancer stem cell function, and promoting tumor development. Gastric cancer (GC) is one of the most common malignant tumors worldwide. However, the role of WTAP in GC ...
