Published in Current Hypertension Reports
Purpose of ReviewTo review the findings of trials evaluating pharmacological treatment approaches for hypertension in general, and resistant hypertension (RH) in particular, and propose future research and clinical directions.Recent FindingsRH is defined as blood pressure (BP) that remains above target levels despite adherence to at least three ant...
Published in Indian Journal of Gynecologic Oncology
PurposeOvarian cancer is the seventh most common cancer in world among women and a leading cause of mortality among all gynaecological malignancies. This is because majority of the ovarian cancer patients are diagnosed at advanced stage of the disease. The lack of specific symptoms and effective screening techniques makes ovarian cancer an extremel...
Published in BMC Infectious Diseases
BackgroundRegimens that could treat both rifampin-resistant (RR) and rifampin-susceptible tuberculosis (TB) while shortening the treatment duration have reached late-stage clinical trials. Decisions about whether and how to implement such regimens will require an understanding of their likely clinical impact and how this impact depends on local epi...
Published in Respiratory Research
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a dismal prognosis. The average life expectancy of untreated patients with IPF is only 3 to 4 years. Decline in forced vital capacity (FVC) in patients with IPF appears to be almost linear, with patients with well-preserved FVC at baseline experiencing the same rate of decline in FVC...
Published in Bulletin of the National Research Centre
BackgroundOcular toxocariasis is considered a parasitic disease of major socioeconomic importance. In spite of the high prevalence of human toxocariasis (up to 84%) among Egyptian patients, the incidence of ocular toxocariasis is underestimated. The recognition of this neglected disease would be the initial step to overcome it. Thus, this review ga...
Published in BMC Pediatrics
IntroductionIron deficiency anemia (IDA) is a global public health issue that affect more than 2 billion individuals worldwide. However evidence for optimal management of IDA is lacking.MethodsTo assess the diagnostic criteria and therapeutic modalities for pediatric IDA employed by physicians in a major public healthcare facility in Riyadh, a vali...
Published in BMC Musculoskeletal Disorders
BackgroundOsteoarthritis (OA) is the most common joint disorder among elderly individuals. Nonsurgical treatment plays an important role in treating knee OA. The aim of the present study was to investigate the trends and research status about nonsurgical treatment of knee OA.MethodsPublications about the nonsurgical treatment of knee OA from 1994 t...
Published in BMC Psychiatry
Several international guidelines for the acute treatment of moderate to severe unipolar depression recommend a first-line treatment with antidepressants (AD). This is based on the assumption that AD obviously outperform placebo, at least in the case of severe depression. The efficacy of AD for severe depression can only be definitely clarified with...
Published in BMC Cardiovascular Disorders
BackgroundColchicine has been used as anti-inflammatory agent in pericardial effusion (PE). We sought to perform a meta-analysis of randomized trials assessing the efficacy and safety of colchicine in patients with pericarditis or postpericardiotomy syndrome (PPS).MethodsIn the systematic literature search following the PRISMA statement, 10 prospec...
Published in Current Rheumatology Reports
Purpose of the ReviewMost of the primary vasculitis in children and adults has different clinical manifestations for the same disease, which suggests that they might not be part of the same clinical spectrum and requires a different approach in order to reduce the morbidity and mortality of these patients. In this work, we review the most recent li...
