Okonkwo, David McAllister, Peter Achrol, Achal Karasawa, Yasuaki Kawabori, Masahito Cramer, Steven Lai, Albert Kesari, Santosh Frishberg, Benjamin Groysman, Leonid
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BACKGROUND AND OBJECTIVES: Traumatic brain injury (TBI) is frequently characterized by chronic motor deficits. Therefore, this clinical trial assessed whether intracranial implantation of allogeneic modified mesenchymal stromal (SB623) cells can improve chronic motor deficits after TBI. METHODS: Post hoc analysis of the double-blind, randomized, pr...
Patel, Herry Nooner, Kate Brody Reich, Jessica C Woodley, Mary Milo O Cummins, Kevin Brown, Sandra A
PurposeTraumatic brain injury (TBI) and potentially traumatic events (PTEs) contribute to increased substance use, mental health issues, and cognitive impairments. However, there's not enough research on how TBI and PTEs combined impact mental heath, substance use, and neurocognition.MethodsThis study leverages a subset of The National Consortium o...
Samanta, Romit Chiollaz, Anne-Cécile Needham, Edward Yue, John Helmy, Adel Zanier, Elisa Wang, Kevin Kobeissy, Firas Posti, Jussi Summers, Charlotte
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BACKGROUND: The inflammatory response in patients with traumatic brain injury (TBI) offers opportunities for stratification and intervention. Previous unselected approaches to immunomodulation in patients with TBI have not improved patient outcomes. METHODS: Serum and plasma samples from two prospective, multi-centre observational studies of patien...
Djebbara-Bozo, Nulvin Pedersen, Emilie Arntoft Serifi, Maria Arvad Petersen, Christian Nikolaj
Published in
International journal of surgery case reports
Traumatic injury of a vascular prosthesis-to-prosthesis anastomosis leading to an extravasation and pseudoaneurysm is rare. If not identified the complications associated with this condition can lead to high morbidity and mortality and require surgical treatment. We describe a patient who presented with a tear in prosthesis-prosthesis anastomosis e...
Wang, Dongsheng Li, Xiaojing Li, Wenxi Duong, Tiffany Wang, Hongxia Kleschevnikova, Natalia Patel, Hemal H Breen, Ellen Powell, Susan Wang, Shanshan
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Background and purposeTraumatic brain injury (TBI) causes lifelong physical and psychological dysfunction in affected individuals. The current study investigated the effects of chronic nicotine exposure via E-cigarettes (E-cig) (vaping) on TBI-associated behavioural and biochemical changes.Experimental approachAdult C57/BL6J male mice were subjecte...
Tignanelli, Christopher Shah, Surbhi Vock, David Siegel, Lianne Serrano, Carlos Haut, Elliott Switzer, Sean Martin, Christie Rizvi, Rubina Peta, Vincent
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BACKGROUND: Venous thromboembolism (VTE) is a preventable medical condition which has substantial impact on patient morbidity, mortality, and disability. Unfortunately, adherence to the published best practices for VTE prevention, based on patient centered outcomes research (PCOR), is highly variable across U.S. hospitals, which represents a gap be...
Singh, Aditya Gong, Steven Vu, Anh Li, Scott Obenaus, Andre
Traumatic brain injury (TBI) survivors face debilitating long-term psychosocial consequences, including social isolation and depression. TBI modifies neurovascular physiology and behavior but the chronic physiological implications of altered brain perfusion on social interactions are unknown. Adult C57/BL6 male mice received a moderate cortical TBI...
Omar, Samira Williams, Charmaine Bugg, Laura Beth Colantonio, Angela
BACKGROUND: Over two decades of research about traumatic brain injury (TBI) rehabilitation emphasized the persistence of racial health disparities in functional outcomes that disproportionately impact Black populations without naming or addressing racism as the root problem. Further, the experiences of Black people with TBI have yet to be documente...
Ack, Sophie Dolmans, Rianne Foreman, Brandon Manley, Geoffrey Rosenthal, Eric Zabihi, Morteza
IMPORTANCE: Treatment for intracranial pressure (ICP) has been increasingly informed by machine learning (ML)-derived ICP waveform characteristics. There are gaps, however, in understanding how ICP monitor type may bias waveform characteristics used for these predictive tools since differences between external ventricular drain (EVD) and intraparen...
Parra Bravo, Celeste Krukowski, Karen Barker, Sarah Wang, Chao Li, Yaqiao Fan, Li Vázquez-Rosa, Edwin Shin, Min-Kyoo Wong, Man McCullough, Louise
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BACKGROUND: Tau is aberrantly acetylated in various neurodegenerative conditions, including Alzheimers disease, frontotemporal lobar degeneration (FTLD), and traumatic brain injury (TBI). Previously, we reported that reducing acetylated tau by pharmacologically inhibiting p300-mediated tau acetylation at lysine 174 reduces tau pathology and improve...