Published in BMC Genetics
BackgroundThe Oriental fruit fly, Bactrocera dorsalis, is a highly polyphagous invasive species with a high reproductive potential. In many tropical and subtropical parts of the world it ranks as one of the major pests of fruits and vegetables. Due to its economic importance, genetic, cytogenetic, genomic and biotechnological approaches have been a...
Published in Chromosoma
Heterochromatin protein 1a (HP1a) is a well-known component of pericentromeric and telomeric heterochromatin in Drosophila. However, its role and the mechanisms of its binding in the chromosome arms (ChAs) remain largely unclear. Here, we identified HP1a-interacting domains in the somatic cells of Drosophila ovaries using a DamID-seq approach and c...
Published in Seminars in cell & developmental biology
Comprising ~40% of the human genome, retroelements are mobile genetic elements which are transcribed into RNA, then reverse-transcribed into DNA and inserted into a new site in the genome. Retroelements are referred to as "genetic parasites", residing among host genes and relying on host machinery for transcription and evolutionary propagation. The...
Les transferts horizontaux (TH) d’ADN sont de plus en plus reconnus comme un phénomène important dans l’évolution des métazoaires. La grande majorité des TH entre animaux implique des éléments transposables (ET), séquences génomiques égoïstes capables de se déplacer par transposition dans le génome et générer ainsi de multiples copies. Si ces TH d’...
Published in World Journal of Microbiology and Biotechnology
The fermentation of industrial bacteria encounters a serious problem in continuous culture, i.e. the production traits lose. However, current research on the mechanism of strain degeneration is not clear enough, and there are few methods to effectively control the degeneration. Under growth restriction, the mutation rate of fermentation strains inc...
Published in Zoological Research
Understanding the genetic mechanisms underlying particular adaptations/phenotypes of organisms is one of the core issues of evolutionary biology. The use of genomic data has greatly advanced our understandings on this issue, as well as other aspects of evolutionary biology, including molecular adaptation, speciation, and even conservation of endang...
Published in Mobile DNA
BackgroundTc1/mariner transposons are widespread DNA transposable elements (TEs) that have made important contributions to the evolution of host genomic complexity in metazoans. However, the evolution and diversity of the Tc1/mariner superfamily remains poorly understood. Following recent developments in genome sequencing and the availability of a ...
Published in Mobile DNA
Genomics and other large-scale analyses have drawn increasing attention to the potential impacts of transposable elements (TEs) on their host genomes. However, it remains challenging to transition from identifying potential roles to clearly demonstrating the level of impact TEs have on genome evolution and possible functions that they contribute to...
Published in Mobile DNA
BackgroundThe cell-surface attachment protein (Env) of the HERV-K(HML-2) lineage of endogenous retroviruses is a potentially attractive tumour-associated antigen for anti-cancer immunotherapy. The human genome contains around 100 integrated copies (called proviruses or loci) of the HERV-K(HML-2) virus and we argue that it is important for therapy d...
Published in BMC Evolutionary Biology
BackgroundThe piwi-interacting RNAs (piRNAs) are small non-coding RNAs that specifically repress transposable elements (TEs) in the germline of Drosophila. Despite our expanding understanding of TE:piRNA interaction, whether there is an evolutionary arms race between TEs and piRNAs was unclear.ResultsHere, we studied the population genomics of TEs ...
