Verhoeven, Jeroen G H P Baan, Carla C Peeters, Annemiek M A Clahsen-van Groningen, Marian C Nieboer, Daan Herzog, Mariëlle Eccleston, Marc Hesselink, Dennis A Boer, Karin
Published in
Clinical epigenetics
There is an unmet need for noninvasive markers specific for kidney transplant rejection. Such a marker may eventually overcome the need for a transplant biopsy. In this pilot study, the potential of circulating cell-free nucleosomes (CCFN) to serve as a biomarker for kidney transplant rejection was evaluated. Forty de novo kidney transplant recipie...
Henrique-Neto, Álvaro Vasconcelos, Marianna Yumi Kawashima Dias, Juliana Bernardes Elias de Moraes, Daniela Aparecida Gonçalves, Maynara Santana Zanin-Silva, Djúlio César Zucoloto, Talita Graminha de Oliveira, Marília de Fátima Cirioli Dotoli, Giuliana Martinelli Weffort, Luiz Fernando
...
Published in
Advances in Rheumatology
BackgroundIn the past 20 years, hematopoietic stem cell transplantation (HSCT) has been investigated as treatment for systemic sclerosis (SSc). The goal of HSCT is to eradicate the autoreactive immune system, which is replaced by a new immune repertoire with long-lasting regulation and tolerance to autoantigens. Here, we describe the clinical outco...
Shiroma, Marcos Eiji Damous, Luciana Lamarão Cotrim, Fernanda Pereira Roa, Cristiane Lima Cipolla-Neto, José Reiter, Russel Joseph Baracat, Edmund Chada Soares, José Maria Jr
Published in
Reproductive Biology and Endocrinology
BackgroudMelatonin has anti-inflammatory and antioxidative actions at the mitochondrial level. This indole-containing molecule may protect ovarian grafts during the process of cryopreservation. Therefore, we aimed to determine whether melatonin pretreatment improves rat ovarian graft quality.MethodsTwenty-six female rats were allocated to two study...
Jashari, Ramadan
Published in
Cell and Tissue Banking
For over 30 years, our TE has processed, controlled for quality and distributed cryopreserved allograft valves for human application. We present a review of this activity and future perspectives of cardiovascular tissue banking. The donor age and medical/behavioral history are in compliance with the regulations of the EUMS. Allograft morphology and...
Tackmann, E Dettmer, S
Published in
Medizinische Klinik, Intensivmedizin und Notfallmedizin
In den vergangenen Jahren bleibt die postmortale Organspenderate in Deutschland niedrig. Ziel der vorliegenden Arbeit ist es, auf der Grundlage von bundesweiten Repräsentativbefragungen der Bundeszentrale für gesundheitliche Aufklärung (BZgA) 1) die Entwicklung des Organspendeausweisbesitzes seit 2010 sowie 2) die Einflussfaktoren auf den Besitz ei...
Focosi, Daniele Franchini, Massimo
Published in
Transfusion and Apheresis Science
The outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS−COV-2), generated an unprecedented global health and social emergency. Despite many efforts from clinicians to develop effective anti−COVID-19 treatment protocols, no specific therapy is currently available. Among anti-viral agents, ...
Tsai, May-Jywan Hung, Shih-Chieh Weng, Ching-Feng Fan, Su-Fen Liou, Dann-Ying Huang, Wen-Cheng Liu, Kang-Du Cheng, Henrich
Published in
World Journal of Stem Cells
BACKGROUND Parkinson’s disease (PD) is a neurological disorder characterized by the progressive loss of midbrain dopamine (DA) neurons. Bone marrow mesenchymal stem cells (BMSCs) can differentiate into multiple cell types including neurons and glia. Transplantation of BMSCs is regarded as a potential approach for promoting neural regeneration. Glia...
Gładyś, Aleksandra Kozak, Sylwia Wdowiak, Kamil Winder, Mateusz Chudek, Jerzy
Published in
World Journal of Clinical Cases
BACKGROUND Post-transplant lymphoproliferative disease (PTLD) is a heterogeneous group of diseases that develop after solid organ and hematopoietic stem cells transplantation related to intensive immunosuppression regimen, T-cell depletion and Epstein-Barr virus infection. Despite the improvement in the management of PTLD, the prognosis remains poo...
Zanella, M. C. Cordey, S. Laubscher, F. Docquier, M. Vieille, G. Van Delden, C. Braunersreuther, V. TA, Mc Kee Lobrinus, J. A. Masouridi-Levrat, S.
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Published in
Microbiome
BackgroundViral infections are common complications following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Allo-HSCT recipients with steroid-refractory/dependent graft-versus-host disease (GvHD) are highly immunosuppressed and are more vulnerable to infections with weakly pathogenic or commensal viruses. Here, twenty-five adult a...
Lim, Hooi Ching Soneji, Shamit Pálmason, Róbert Lenhoff, Stig Laurell, Thomas Scheding, Stefan
Published in
Biomarker Research
BackgroundInfection and graft-versus-host disease (GvHD) are the major causes for mortality and morbidity of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Plasma-derived extracellular vesicles (EVs) contain disease-related proteins, DNAs and RNAs, and have recently been suggested as potential biomarker candidates for transplantati...