Published in Clinical epigenetics
There is an unmet need for noninvasive markers specific for kidney transplant rejection. Such a marker may eventually overcome the need for a transplant biopsy. In this pilot study, the potential of circulating cell-free nucleosomes (CCFN) to serve as a biomarker for kidney transplant rejection was evaluated. Forty de novo kidney transplant recipie...
Published in Advances in Rheumatology
BackgroundIn the past 20 years, hematopoietic stem cell transplantation (HSCT) has been investigated as treatment for systemic sclerosis (SSc). The goal of HSCT is to eradicate the autoreactive immune system, which is replaced by a new immune repertoire with long-lasting regulation and tolerance to autoantigens. Here, we describe the clinical outco...
Published in Reproductive Biology and Endocrinology
BackgroudMelatonin has anti-inflammatory and antioxidative actions at the mitochondrial level. This indole-containing molecule may protect ovarian grafts during the process of cryopreservation. Therefore, we aimed to determine whether melatonin pretreatment improves rat ovarian graft quality.MethodsTwenty-six female rats were allocated to two study...
Published in Cell and Tissue Banking
For over 30 years, our TE has processed, controlled for quality and distributed cryopreserved allograft valves for human application. We present a review of this activity and future perspectives of cardiovascular tissue banking. The donor age and medical/behavioral history are in compliance with the regulations of the EUMS. Allograft morphology and...
Published in Medizinische Klinik, Intensivmedizin und Notfallmedizin
In den vergangenen Jahren bleibt die postmortale Organspenderate in Deutschland niedrig. Ziel der vorliegenden Arbeit ist es, auf der Grundlage von bundesweiten Repräsentativbefragungen der Bundeszentrale für gesundheitliche Aufklärung (BZgA) 1) die Entwicklung des Organspendeausweisbesitzes seit 2010 sowie 2) die Einflussfaktoren auf den Besitz ei...
Published in Transfusion and Apheresis Science
The outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS−COV-2), generated an unprecedented global health and social emergency. Despite many efforts from clinicians to develop effective anti−COVID-19 treatment protocols, no specific therapy is currently available. Among anti-viral agents, ...
Published in World Journal of Stem Cells
BACKGROUND Parkinson’s disease (PD) is a neurological disorder characterized by the progressive loss of midbrain dopamine (DA) neurons. Bone marrow mesenchymal stem cells (BMSCs) can differentiate into multiple cell types including neurons and glia. Transplantation of BMSCs is regarded as a potential approach for promoting neural regeneration. Glia...
Published in World Journal of Clinical Cases
BACKGROUND Post-transplant lymphoproliferative disease (PTLD) is a heterogeneous group of diseases that develop after solid organ and hematopoietic stem cells transplantation related to intensive immunosuppression regimen, T-cell depletion and Epstein-Barr virus infection. Despite the improvement in the management of PTLD, the prognosis remains poo...
Published in Microbiome
BackgroundViral infections are common complications following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Allo-HSCT recipients with steroid-refractory/dependent graft-versus-host disease (GvHD) are highly immunosuppressed and are more vulnerable to infections with weakly pathogenic or commensal viruses. Here, twenty-five adult a...
Published in Biomarker Research
BackgroundInfection and graft-versus-host disease (GvHD) are the major causes for mortality and morbidity of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Plasma-derived extracellular vesicles (EVs) contain disease-related proteins, DNAs and RNAs, and have recently been suggested as potential biomarker candidates for transplantati...
