Chua, Alfredo V Jr Hernandez, Aylmer Rex B Real, Irisyl O
Published in
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
To compare the efficacy of transdermal granisetron versus oral granisetron in controlling chemotherapy-induced nausea and vomiting (CINV) in patients with cancer METHODS: Data sources were CENTRAL, MEDLINE, EMBASE, Clinicaltrials.gov , and Google Scholar. Inclusion criteria included randomized controlled trials comparing transdermal versus oral gra...
Zhang, Shuang Song, Wenting Wu, Hangyi Wang, Jiao Wang, Yuling Zhang, Zhenhai Lv, Huixia
Published in
International journal of pharmaceutics
Fungal infections are one of the major skin healthcare issues and cause significant morbidity. Ketoconazole (KC) as a broad-spectrum antifungal drug is widely used to treat skin fungal diseases. However, its therapeutic effects are limited by low concentration, short duration of drug efficacy in the skin and severe systemic toxicity. Here, the keto...
Nelson, Anita L Kaunitz, Andrew M Kroll, Robin Simon, James A Poindexter, Alfred N Castaño, Paula M Ackerman, Ronald T Flood, Lisa Chiodo, Joseph A 3rd Garner, Elizabeth Io
...
Published in
Contraception
To assess the contraceptive efficacy, safety, and tolerability of a contraceptive transdermal delivery system, (TDS; TWIRLAⓇ) containing levonorgestrel (LNG) and ethinyl estradiol (EE). This single-arm, open-label, multicenter, 1-year (13 cycle), phase 3 study enrolled sexually active women ≥18 years old at risk for pregnancy irrespective of body m...
Youn, Nam Hee Kim, Eun Ji Yi, Jung-Sun Kim, Joo Hwan Cho, Ye-Jin Nam, Ki Taek Park, Ki Sook Lee, Jong Kwon
Published in
Laboratory Animal Research
Some drugs cause phototoxicity in humans when exposed to light, thus there is a need for an in vivo phototoxicity test to evaluate them. However, an in vivo phototoxicity test method to evaluate this has not been established. This study aimed to establish an in vivo phototoxicity test method for transdermally administered drugs. For this, we evalua...
Srivastava, Praveen K Thakkar, Hetal P
Published in
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Vinpocetine (VPN) displays poor bioavailability (~7%) and short half-life (2-3 h) justifying the frequent dosing requirement of currently marketed oral tablets (thrice daily) and thus, posing a great challenge to patient compliance. Present work envisaged to achieve an infusion like delivery through transdermal route so as to tackle aforesaid chall...
Elsayed, Ibrahim El-Dahmy, Rania Moataz El-Emam, Soad Z Elshafeey, Ahmed Hassen El Gawad, Nabaweya Abdelaziz Abd El-Gazayerly, Omaima Naim
Published in
Drug delivery and translational research
Statins are mainly used for the treatment of hyperlipidemia, but recently, their anticancer role was extremely investigated. The goal of this study was to statistically optimize novel elastic nanovesicles containing rosuvastatin calcium to improve its transdermal permeability, bioavailability, and anticancer effect. The elastic nanovesicles were co...
Al Jeraisy, Majed AlFuraih, Maissa AlSaif, Raghad AlKhalifah, Bushra AlOtaibi, Hazza Abolfotouh, Mostafa A.
Published in
BMC Pediatrics
BackgroundDrooling is common in children with neurological disorders, but its management is very challenging, Scopolamine transdermal patch (STP) appears to be useful in controlling drooling, although it is not approved for this indication and there are limited clinical studies about its effectiveness. This study aimed (1) to assess the impact of S...
Fairbairn, Catharine E Kang, Dahyeon Bosch, Nigel
Published in
Drug and alcohol dependence
Transdermal biosensors offer a noninvasive, low-cost technology for the assessment of alcohol consumption with broad potential applications in addiction science. Older-generation transdermal devices feature bulky designs and sparse sampling intervals, limiting potential applications for transdermal technology. Recently a new-generation of transderm...
Wang, Shiyi Jiang, Rihua Meng, Tianqi Zhang, Fuqiang Li, Jing Jin, Yongri Lee, JeungHoon Zhu, Mingji Jiang, Jinlan
Published in
Journal of Nanobiotechnology
BackgroundTopical isotretinoin is commonly used to treat acne. However, topical isotretinoin has side effects and can hardly permeate through the stratum corneum, the most important skin barrier. Therefore, this study aimed to demonstrate the efficacy of nanoparticles as stable carriers with great curative effects, low side effects, and strong tran...
Halder, Jitu Gupta, Sudhanshu Kumari, Rakhi Gupta, Ghanshyam Das Rai, Vineet Kumar
Published in
Journal of pharmaceutical innovation
Drug delivery through the skin by transdermal patches has a long history. Subsequent growth of transdermal science proved prominent utility of transdermal systems meant for passive diffusion of the drug. It was followed by the development of iontophoresis- and sonophoresis-based transdermal delivery systems. Microneedle array has now caught attenti...
