Georgy, Smitha Rose Rudiatmoko, Diar Riyanti Auden, Alana Partridge, Darren Butt, Tariq Srivastava, Seema Wong, Nick Swaroop, Dijina Carpinelli, Marina Rose Yan, Feng
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Published in
Cellular and molecular gastroenterology and hepatology
Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with a poor long-term prognosis. The molecular mechanisms underlying the initiation and progression of this tumor are largely unknown. The transcription factor GRHL3 functions as a potent tumor suppressor in SCC of skin, head, and neck. This study aims to determine whether GRHL3 ...
Delos Santos, Nathaniel
Transcription factors (TFs) mediate transcriptional responses, allowing cells to respond to changing internal or external stimuli, including infection. The DNA sequences bound by TFs in regulatory regions are called motifs. Researchers employ Motif Enrichment Analysis (MEA) methods to study transcriptional regulation, which analyzes DNA sequences f...
Dragan, Morgan Ashley
The skin barrier has plethora of important functions including protection from and triggering the inflammatory response to mechanical, thermal and physical injury and provides insulation against moisture loss. Skin barrier is formed by the continuous proliferation and maturation of keratinocytes. The focus of this dissertation is to understand epit...
DeLaForest, Ann Kohlnhofer, Bridget M Franklin, Olivia D Stavniichuk, Roman Thompson, Cayla A Pulakanti, Kirthi Rao, Sridhar Battle, Michele A
Published in
Cellular and molecular gastroenterology and hepatology
The transcription factor GATA4 is broadly expressed in nascent foregut endoderm. As development progresses, GATA4 is lost in the domain giving rise to the stratified squamous epithelium of the esophagus and forestomach (FS), while it is maintained in the domain giving rise to the simple columnar epithelium of the hindstomach (HS). Differential GATA...
Banks, Carmen M
The cell-specific actions for prolactin (PRL) are dependent on the coordinated transcriptional regulation of the prolactin receptor (PRLR) gene across tissues. Several lines of evidence indicate that the use of multiple promoters underlies the tissue specific regulation for PRLR expression in states such as pregnancy and lactation. However, the rol...
Roth, Samuel
Transcription termination is a fundamental process in gene regulation. It is a critical step in mRNA maturation and it has been found that several cellular stresses can disrupt transcription termination. When termination is disrupted, transcription continues past the annotated 3’ end of genes (called readthrough transcription). This has many downst...
Read, Kaitlin A. Jones, Devin M. Freud, Aharon G. Oestreich, Kenneth J.
Published in
Immunological reviews
Ikaros zinc finger transcription factors are important regulators of the gene programs underlying the development of hematopoietic cell lineages. The family consists of five members: Ikaros, Helios, Aiolos, Eos, and Pegasus, which engage in both homo- and heterotypic intrafamilial interactions to exert diverse functional effects. Pioneering studies...
Perusina Lanfranca, Mirna Zhang, Yaqing Girgis, Alexander Kasselman, Samantha Lazarus, Jenny Kryczek, Illona Delrosario, Lawrence Rhim, Andrew Koneva, Lada Sartor, Maureen
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Background & aimsPancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy that invades surrounding structures and metastasizes rapidly. Although inflammation is associated with tumor formation and progression, little is known about the mechanisms of this connection. We investigate the effects of interleukin (IL) 22 in the development of ...
Perusina Lanfranca, Mirna Zhang, Yaqing Girgis, Alexander Kasselman, Samantha Lazarus, Jenny Kryczek, Illona Delrosario, Lawrence Rhim, Andrew Koneva, Lada Sartor, Maureen
...
Published in
Gastroenterology
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy that invades surrounding structures and metastasizes rapidly. Although inflammation is associated with tumor formation and progression, little is known about the mechanisms of this connection. We investigate the effects of interleukin (IL) 22 in the development of pancreatic tumors...
Sastry, Anand Varun
Bacteria respond and adapt to dynamic environments by altering their gene expression through a complex Transcriptional Regulatory Network (TRN). Advances in sequencing technologies have accelerated the generation of large RNA sequencing datasets that can be leveraged to probe the TRN. Here, we analyze large gene expression datasets using Independen...
