Tosi, M Matelloni, I A Mancini, M Andreassi, A Scopari, A Rossi, A Verduci, E Berra, C Manfrini, R Banderali, G
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Published in
Journal of endocrinological investigation
Childhood obesity is on the rise worldwide increasing the risk for metabolic, cardiovascular and liver diseases in children. Eating habits and lifestyle changes are currently the standard of care for treating pediatric obesity. Our study aimed to determine the impact of a dietary intervention based on the Mediterranean Diet (MD) and the Health Eati...
Roda, Sergi Fernandez‐Lopez, Laura Benedens, Marius Bollinger, Alexander Thies, Stephan Schumacher, Julia Coscolín, Cristina Kazemi, Masoud Santiago, Gerard Gertzen, Christoph G. W.
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Published in
Angewandte Chemie (International Ed. in English)
A PluriZyme with transaminase and esterase activities was constructed by combining computational and laboratory design methods. The enzyme can perform cascade reactions in a single protein scaffold. Experimental evidence is presented for the catalytic efficiency of both the native transaminase and the artificial esterase active site and their syner...
Sobotka, Lindsay A Esteban, James Volk, Michael L Elmunzer, B Joseph Rockey, Don C
Published in
Digestive diseases and sciences
The prevalence and significance of acute liver injury in patients with COVID-19 are poorly characterized. Patients with confirmed COVID-19 who were hospitalized in geographically diverse medical centers in North America were included. Demographics, symptoms, laboratory data results, and outcomes were recorded. Linear and logistic regression identif...
Karaarslan, Utku Çolak, Mustafa Topal, Sevgi Atakul, Gülhan Soydan, Ekin Çağlar, Aykut Ağın, Hasan
Published in
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
The aim of this study was to determine the association between the use of intravenous N-acetylcysteine (NAC) and hepatic healing in pediatric intensive care unit (PICU) patients with non-acetaminophen-induced hepatic injury, except for acute liver failure. The data of patients who received intravenous NAC as adjuvant therapy for transaminase levels...
Jin, Li-Qun Shentu, Jun-Kang Liu, Han-Lin Shao, Tian-Chen Liu, Zhi-Qiang Xue, Ya-Ping Zheng, Yu-Guo
Published in
Journal of biotechnology
Transaminases catalyze the transfer of an amino group from a donor to a keto group of an acceptor substrate and are applicable to the asymmetric synthesis of herbicide L-phosphinothricin (L-PPT). Here, the important residue sites (C390, I22, V52, R141, Y138 and D239) of transaminase from Salmonella enterica (SeTA) were modified at the adjacency of ...
Johansson, Johannes
Den nära förestående bristen på fossila resurser i kombination med deras associerade miljöfarlighet betonar behovet av utveckling av alternativa, mer hållbara kemikalier. I denna studie utvecklades en enzymatisk kaskad för förädling av 5-(hydroxymetyl)furfural (HMF) till 5-(aminometyl)-2-furfuraldehyd (AMFA). Kaskaden omfattar transaminering av HMF...
Lambhiya, Shraddha Patel, Gopal Banerjee, Uttam Chand
Published in
Bioresources and Bioprocessing
This study reports the isolation and partial purification of transaminase from the wild species of Bacillus licheniformis. Semi-purified transaminase was immobilized on copper nanoflowers (NFs) synthesized through sonochemical method and explored it as a nanobiocatalyst. The conditions for the synthesis of transaminase NFs [TA@Cu3(PO4)2NF] were opt...
Lancien, Antoine
L’objectif de la catalyse hybride est d’exploiter les avantages des catalyseurs biologiques et chimiques afin d’accéder à de nouvelles voies de synthèse qui ne peuvent être réalisées indépendamment ou de réaliser des transformations qui ont montré de faibles rendements avec les approches conventionnelles. Le 5-hydroxyméthylfurfural (HMF) est une mo...
Gourbeyre, Léa
Ce travail de thèse avait deux objectifs principaux. D’une part, la recherche de nouvelles ATA via le criblage de banques d’enzymes issues de la biodiversité et d’autre part le développement de nouveaux procédés biocatalytique associant AL et TA. Nous avons développé deux tests de criblages originaux permettant le criblage haut débit des collection...
Cococcia, Sara Lenti, Marco Vincenzo Santacroce, Giovanni Achilli, Giovanna Borrelli de Andreis, Federica Di Sabatino, Antonio
Published in
World Journal of Gastroenterology
Coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an acute infectious disease that spreads mainly through the respiratory route. Besides interstitial pneumonia, a number of other clinical manifestations were noticed in COVID-19 patients. In particular, liver and spleen dysfunct...
