Keil, Claudia Hübner, Christopher Richter, Constanze Lier, Sandy Barthel, Lars Meyer, Vera Subrahmanyam, Raman Gurikov, Pavel Smirnova, Irina Haase, Hajo
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Chronic non-healing wounds represent a substantial economic burden to healthcare systems and cause a considerable reduction in quality of life for those affected. Approximately 0.5–2% of the population in developed countries are projected to experience a chronic wound in their lifetime, necessitating further developments in the area of wound care m...
Zheng, Wenjin Xu, Qing Zhang, Yiyuan Xiaofei, E. Gao, Wei Zhang, Mogen Zhai, Weijie Rajkumar, Ronaldjit Singh Liu, Zhijun
Published in
Virology Journal
BackgroundIn the past decades, researchers have demonstrated the critical role of Toll-like receptors (TLRs) in the innate immune system. They recognize viral components and trigger immune signal cascades to subsequently promote the activation of the immune system.Main bodyHerpesviridae family members trigger TLRs to elicit cytokines in the process...
Zeng-Brouwers, Jinyang Pandey, Sony Trebicka, Jonel Wygrecka, Malgorzata Schaefer, Liliana
Published in
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Inflammation is a highly regulated biological response of the immune system that is triggered by assaulting pathogens or endogenous alarmins. It is now well established that some soluble extracellular matrix constituents, such as small leucine-rich proteoglycans (SLRPs), can act as danger signals and trigger aseptic inflammation by interacting with...
Guerrieri, Ania Naila Zacchini, Federico Onofrillo, Carmine Di Viggiano, Sara Penzo, Marianna Ansuini, Alessio Gandin, Ilaria Nobe, Yuko Taoka, Masato Isobe, Toshiaki
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Published in
Cancers
Dyskerin is a nucleolar protein involved in the small nucleolar RNA (snoRNA)-guided pseudouridylation of specific uridines on ribosomal RNA (rRNA), and in the stabilization of the telomerase RNA component (hTR). Loss of function mutations in DKC1 causes X-linked dyskeratosis congenita, which is characterized by a failure of proliferating tissues an...
Rai, Gargi Das, Shukla Ansari, Mohammad Ahmad Singh, Praveen Kumar Dar, Sajad Ahmad Haque, Shafiul Gupta, Neelima Sharma, Sonal Ramachandran, Vishnampettai Ganapathysub... Sharma, Sanskriti
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Published in
Microbial Cell Factories
BackgroundT helper (Th)17 and regulatory T (Treg) cells with toll-like receptor (TLR)-2 have been acknowledged to play a critical role in chronic rhinosinusitis with nasal polyposis (CRSwNP). However, its pathogenesis has been perplexed by conflicting reports on the role of Th17/Treg cells in patients of distinct ethnicities. We attempted to unders...
Rasaei, Roya Sarodaya, Neha Kim, Kye-Seong Ramakrishna, Suresh Hong, Seok-Ho
Published in
International journal of molecular sciences
Ubiquitination and deubiquitination play a fundamental role in the signaling pathways associated with innate and adaptive immune responses. Macrophages are key sentinels for the host defense, triggering antiviral and inflammatory responses against various invading pathogens. Macrophages recognize the genetic material of these pathogens as pathogen-...
Terada, Takumi Nii, Takahiro Isobe, Naoki Yoshimura, Yukinori
Published in
The Journal of Poultry Science
The aim of this study was to determine the effects of live probiotics Lactobacillus reuteri (LR) and Clostridium butyricum (CB) on the expression of genes of innate immune system in broiler chick ileum and cecum. Chicks were administered 500 µl water with or without LR or CB, daily from day 1 to 6 after hatching. The ileum and cecum were collected ...
Zhang, Yanlin Zhao, Jian Guan, Li Mao, Lijun Li, Shuqiang Zhao, Jinyuan
Published in
Journal of Occupational Medicine and Toxicology
BackgroundChlorine gas (Cl2) exposure remains a public health concern in household, occupational, and transportation accidents around the world. The death rate associated with acute respiratory distress syndrome (ARDS) caused by high concentrations of Cl2 is very high, mainly because the pathogenesis of ARDS remains unclear. Histone H4 has been ide...
Zhang, Peijian The, Erlinda Nedumaran, Balachandar Ao, Lihua Jarrett, Michael J. Xu, Dingli Fullerton, David A. Meng, Xianzhong
Published in
International Journal of Biological Sciences
Background and Objectives: Chronic valvular inflammation associated with monocyte infiltration promotes calcific aortic valve disease (CAVD) progression. Further, innate immunity in aortic valve interstitial cells (AVICs), mediated by Toll-like receptors (TLRs), up-regulates cellular inflammatory, fibrogenic and osteogenic activities. Currently, th...
Sato, Yusuke Motoyama, Satoru Wakita, Akiyuki Kawakita, Yuta Liu, Jiajia Nagaki, Yushi Nanjo, Hiroshi Ito, Satoru Terata, Kaori Imai, Kazuhiro
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Published in
Esophagus : official journal of the Japan Esophageal Society
Poor oral health is an independent risk factor for upper aerodigestive tract cancers, including esophageal squamous cell carcinoma (ESCC). The pattern recognition receptor Toll-like receptor 4 (TLR4) recognizes lipopolysaccharide in the cell walls of Gram-negative periodontal pathogens associated with the development and progression of ESCC. It is,...