Innate immunity and cardiomyocytes in ischemic heart disease
Published in Life Sciences
TLR3 regulates mycobacterial RNA-induced IL-10 production through the PI3K/AKT signaling pathway
...Published in Cellular Signalling
•Fine-tuning of IL-10 production in the host is essential for TB control.•TLR3 deficiency protects mice from BCG infection.•TLR3-PI3K/AKT mediates BCG-induced IL-10 production in macrophages.•Sensing of mycobacterial RNA by TLR3 is responsible for IL-10 induction.•TLR3 is identified as a novel PRR in mycobacterial diseases such as TB or leprosy.
Absorption, distribution and mechanism of action of SYSADOAS
Published in Pharmacology and Therapeutics
Symptomatic Slow Acting Drugs for Osteoarthritis (SYSADOA), such as hyaluronic acid (HA), chondroitin sulfate (CS) and glucosamine (GlcN) are natural compounds, composed of repeating disaccharides, used to treat patients with osteoarthritis (OA). Many questions about the kinetics and mechanism of action of SYSADOA remain poorly answered. This revie...
Tollip-induced down-regulation of MARCH1
...Published in Results in Immunology
•Splenocytes from MARCH1- and Ii-deficient mice are impaired in cytokine production following TLR stimulation.•MHC class II molecules bind TLR3.•Tollip regulates endocytic trafficking of MHC II proteins and chaperones.•Tollip binds MHC II molecules
Evaluating the role of Toll-like receptors in diseases of the central nervous system
Published in Biochemical Pharmacology
A key part of the innate immune system is a network of pattern recognition receptors (PRRs) and their associated intracellular signalling pathways. Toll-like receptors (TLRs) are one such group of PRRs that detect pathogen associated molecular patterns (PAMPs). Activation of the TLRs with their respective agonists results in the activation of intra...
