Lotfi, Mandana Kazemi, Sohrab Ebrahimpour, Anahita Pourabdolhossein, Fereshteh Satarian, Leila Eghbali, Atiyeh Moghadamnia, Ali Akbar
Published in
Molecular neurobiology
Nonylphenol (NP), a well-known endocrine-disrupter chemical, has several harmful effects on the central nervous system including neuroendocrine disruption, cognitive impairment, and neurotoxicity. Thymoquinone (TQ) is a main bioactive compound in the black seeds of Nigella sativa that has antioxidant, anti-inflammatory, and neuroprotective properti...
Abdelrahim, Maen Esmail, Abdullah Al Saadi, Noor Zsigmond, Eva Al Najjar, Ebtesam Bugazia, Doaa Al-Rawi, Hadeel Alsaadi, Ayat Kaseb, Ahmed O.
Published in
Frontiers in Pharmacology
The COVID-19 pandemic has impacted every country in the world. With more than 400 million cases and more than 5.5 million deaths. The FDA either approved or authorized the emergency use for three vaccines against COVID-19. The treatment options of COVID-19 are very limited. Multiple complementary and alternative medicine modalities were suggested t...
Homayoonfal, Mina Asemi, Zatollah Yousefi, Bahman
Published in
Cellular & Molecular Biology Letters
Despite great advances, therapeutic approaches of osteosarcoma, the most prevalent class of preliminary pediatric bone tumors, as well as bone-related malignancies, continue to demonstrate insufficient adequacy. In recent years, a growing trend toward applying natural bioactive compounds, particularly phytochemicals, as novel agents for cancer trea...
Esharkawy, Eman R Almalki, Faisal Hadda, Taibi Ben
Published in
Bioorganic chemistry
Inflammation, oxidation, and compromised immunity all increase the dangers of COVID-19, whereas many pharmaceutical protocols may lead to increased immunity such as ingesting from sources containing vitamin E and zinc. A global search for natural remedies to fight COVID-19 has emerged, to assist in the treatment of this infamous coronavirus. Nigell...
Al-Qubaisi, Mothanna Sadiq Al-Abboodi, Ashwaq Shakir Alhassan, Fatah H. Hussein-Al-Ali, Samer Flaifel, Moayad Husein Eid, Eltayeb E.M. Alshwyeh, Hussah Abdullah Hussein, Mohd Zobir Alnasser, Sulaiman Mohammed Saeed, Mohammed Ibrahim
...
Published in
Saudi Pharmaceutical Journal : SPJ
In this study, we formulated Thymoquinone-loaded nanocomposites (TQ-NCs) using high-pressure homogenizer without sodium tripolyphosphate. The TQ-NCs were characterized and their anti-inflammatory determined by the response of the LPS-stimulated macrophage RAW 264.7 cells in the production of nitric oxide, prostaglandin E2, tumor necrosis factor-α, ...
Liao, Wei Badri, Waisudin Alhibshi, Amani Dumas, Emilie Ghnimi, Sami Gharsallaoui, Adem Errachid, Abdelhamid Elaïssari, Abdelhamid
International audience
Malik, Safiya Singh, Amardeep Negi, Poonam Kapoor, Vijay Kumar
Published in
Drug discovery today
Thymoquinone (TQ; 2-isopropyl-5-methylbenzo-1, 4-quinone), the main active constituent of Nigella sativa, has been proven to have great therapeutic properties in numerous in vivo and in vitro models. Nevertheless, this molecule is not yet in clinical trials, largely because of its poor bioavailability and hydrophobicity. This review examines the di...
Al-Attar, Atef M.
Published in
Saudi Journal of Biological Sciences
Currently, living organisms are increasingly exposed to many toxic chemicals in the environment. These substances pose a threat to human life, other living organisms and ecosystem. In fact, there is an increasing requirement to search for safe therapeutic sources today. Medicinal plants and natural products have become of great importance globally ...
Özdal Zincir, Özge Özdal, Umut Ünlü, Özge Demirci, Mehmet Katiboğlu, Ahmet Bülent Egil, Edibe Altan Şallı, Gülay
Published in
Odontology
The effectiveness of antifungal agents may be insufficient against resistant strains in some cases of oral candidiasis. The aim of this study was to evaluate the antifungal effect of thymoquinone against Candida albicans , Candida tropicalis , Candida glabrata and Candida krusei strains and the synergistic antifungal activity of these strains in co...
Homayoonfal, Mina Asemi, Zatollah Yousefi, Bahman
Published in
Cellular & Molecular Biology Letters
Cancer is a global disease involving transformation of normal cells into tumor types via numerous mechanisms, with mortality among all generations, in spite of the breakthroughs in chemotherapy, radiotherapy and/or surgery for cancer treatment. Since one in six deaths is due to cancer, it is one of the overriding priorities of world health. Recentl...
