Song, Ha-Lim Kim, Na-Young Park, Jaewan Kim, Meong Il Jeon, Yu-Na Lee, Se-Jong Cho, Kwangmin Shim, Young-Lim Lee, Kyoung-Hye Mun, Yeon-Seon
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Published in
The Journal of clinical investigation
The spatiotemporal pattern of the spread of pathologically modified tau through brain regions in Alzheimer's disease (AD) can be explained by prion-like cell-to-cell seeding and propagation of misfolded tau aggregates. Hence, to develop targeted therapeutic antibodies, it is important to identify the seeding- and propagation-competent tau species. ...
Kogot-Levin, Aviram Riahi, Yael Abramovich, Ifat Mosenzon, Ofri Agranovich, Bella Kadosh, Liat Ben-Haroush Schyr, Rachel Kleiman, Doron Hinden, Liad Cerasi, Erol
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Published in
JCI insight
Diabetes is associated with increased risk for kidney and liver diseases, congestive heart failure, and mortality. Urinary glucose excretion using sodium-glucose cotransporter 2 (SGLT2) inhibitors prevents these adverse outcomes. We performed in vivo metabolic labeling with 13C-glucose in normoglycemic and diabetic mice treated with or without the ...
Otte, Megan Lynn Lama Tamang, Raju Papapanagiotou, Julia Ahmad, Rizwan Dhawan, Punita Singh, Amar B
Published in
World journal of gastroenterology
Mucosal healing (MH) is vital in maintaining homeostasis within the gut and protecting against injury and infections. Multiple factors and signaling pathways contribute in a dynamic and coordinated manner to maintain intestinal homeostasis and mucosal regeneration/repair. However, when intestinal homeostasis becomes chronically disturbed and an inf...
Blumenstein, Irina
Published in
Kompass Dermatologie
Gut microbiota dysbiosis is involved in the development of systemic lupus erythematosus (SLE). The safety and efficacy of fecal microbiota transplantation (FMT) for the treatment of SLE patients has not been explored. In this 12-week, single-arm pilot clinical trial of oral encapsulated fecal microbiome from healthy donors to patients with active S...
Warner, Benjamin E Goins, William F Kramer, Phillip R Kinchington, Paul R
Published in
Current topics in microbiology and immunology
Reactivation of latent varicella-zoster virus (VZV) causes herpes zoster (HZ), which is commonly accompanied by acute pain and pruritus over the time course of a zosteriform rash. Although the rash and associated pain are self-limiting, a considerable fraction of HZ cases will subsequently develop debilitating chronic pain states termed postherpeti...
Tariq, Lubna Arafah, Azher Ali, Shafat Beigh, Saba Dar, Mashooq Ahmad Dar, Tanvir Ul Hassan Dar, Aqib Iqbal Alsaffar, Rana M Masoodi, Mubashir Hussain Rehman, Muneeb U
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Published in
Current topics in medicinal chemistry
The application of nanoparticles in medication delivery has revolutionized the field of therapeutic biology. To improve medical efficacy, currently, drug nanocarriers are employed to control the release and stability, expand its circulation time, or protect it from cell clearance or premature breakdown. A crosslinked polymeric framework is used to ...
Bravo-Vázquez, Luis Alberto Medina-Ríos, Ixchel Márquez-Gallardo, Luis David Reyes-Muñoz, Josué Serrano-Cano, Francisco I Pathak, Surajit Banerjee, Antara Bandyopadhyay, Anindya Duttaroy, Asim K Paul, Sujay
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Published in
Digestive diseases and sciences
MicroRNAs (miRNAs) are tiny (20-24 nucleotides long), non-coding, highly conserved RNA molecules that play a crucial role within the post-transcriptional regulation of gene expression via sequence-specific mechanisms. Since the miRNA transcriptome is involved in multiple molecular processes needed for cellular homeostasis, its altered expression ca...
dhawan, manish rabaan, ali a. al fawarah, mahmoud m. almuthree, souad a. alsubki, roua a. alfaraj, amal h. mashraqi, mutaib m. alshamrani, saleh a. abduljabbar, wesam a. s. alwashmi, ameen s.
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The emergence of novel variants of SARS-CoV-2 and their abilities to evade the immune response elicited through presently available vaccination makes it essential to recognize the mechanisms through which SARS-CoV-2 interacts with the human immune response. It is essential not only to comprehend the infection mechanism of SARS-CoV-2 but also for th...
Li, Mengxing Tang, Heyong Li, Zhen Tang, Wei
Published in
Neuroscience
Cerebral ischemia-reperfusion injury (CI/RI) injury is a common feature of ischemic stroke which occurs when the blood supply is restored after a period of ischemia in the brain. Reduced blood-flow to the brain during CI/RI compromises neuronal cell health as a result of mitochondrial dysfunction, oxidative stress, cytokine production, inflammation...
Sankar, Sathish Ganesh, Pitchaipillai Sankar Subramaniam, Suganya Shankar, Esaki M Yuwanati, Monal Govindasamy, Rajakumar Thiruvengadam, Muthu
Published in
Microbial pathogenesis
In biofilm formation, pathogens within the bacterial community coordinate a cell-cell communication system called quorum sensing (QS). This is achieved through various signalling pathways that regulate bacterial virulence and host immune response. Here, we reviewed the host responses, key clinical implications, and novel therapeutic approaches agai...
