Published in Biosensors & bioelectronics
CRISPR/Cas systems have the ability to precisely target nucleotide sequences and enable their rapid identification and modification. While nucleotide modification has enabled the therapeutic correction of diseases, the process of identifying the target DNA or RNA has greatly expanded the field of molecular diagnostics in recent times. CRISPR-based ...
Published in Molecular biotechnology
The CRISPR-Cas genome editing system is an intrinsic property of a bacteria-based immune system. This employs a guide RNA to detect and cleave the PAM-associated target DNA or RNA in subsequent infections, by the invasion of a similar bacteriophage. The discovery of Cas systems has paved the way to overcome the limitations of existing genome editin...
This is a review of the chemistry, pharmacological and biomedical applications of bicyclic 5-6 systems possessing a five-membered ring with two heteroatoms fused onto a six-membered ring with one heteroatom. During the last decade the synthesis and transformations of these bicyclic 5-6 systems, especially that of imidazo-, pyrazolo-, oxazolo-, thia...
Published in Cell Communication and Signaling
Despite the considerable efforts in screening and diagnostic protocols, prostate cancer still represents the second leading cause of cancer-related death in men. Many patients with localized disease and low risk of recurrence have a favourable outcome. In a substantial proportion of patients, however, the disease progresses and becomes aggressive. ...
Published in Archives of microbiology
The research on human gut microbiome, regarded as the black box of the human body, is still at the stage of infancy as the functional properties of the complex gut microbiome have not yet been understood. Ongoing metagenomic studies have deciphered that the predominant microbial communities belong to eubacterial phyla Firmicutes, Bacteroidetes, Pro...
10.3390/nano11071868 / Nanomaterials / 11 / 7 / 1868
Published in Molecular immunology
Bacteria release extracellular vesicles (EVs) known as bacterial membrane vesicles (BMVs) during their normal growth. Gram-negative bacteria produce BMVs termed outer membrane vesicles (OMVs) that are composed of a range of biological cargo and facilitate numerous bacterial functions, including promoting pathogenesis and mediating disease in the ho...
Published in Pharmacological research
Exposure to the external environment may lead to instability and dysfunction of the skin, resulting in refractory wound, skin aging, pigmented dermatosis, hair loss, some immune-mediated dermatoses, and connective tissue diseases. Nowadays, many skin treatments have not achieved a commendable balance between medical recovery and cosmetic needs. Exo...
Published in Natural Products and Bioprospecting
Flavonoids are now considered as an indispensable component in a variety of nutraceutical and pharmaceutical applications. Most recent researches have focused on the health aspects of flavonoids for humans. Especially, different flavonoids have been investigated for their potential antiviral activities, and several natural flavonoids exhibited sign...
Published in International journal of biological macromolecules
Plastic accumulation has destructive environmental impacts, so the world needs eco-friendly plastic alternatives. Within this context, polyhydroxyalkanoates (PHAs) appear to be real alternatives to the chemical plastics because they are biocompatible and biodegradable. Despite its similar properties to common plastics, PHAs use is still hampered by...
