Cai, Lu Wei, Yi Zhao, Min Zhuo, Jia Tao, Xiao Lin, Mao
Published in
Frontiers in Medicine
Alopecia areata (AA) is a non-scarring hair loss disorder. Alopecia totalis (AT) and alopecia universalis (AU) are the severe subtypes of AA. Age of onset before 6 years of age, disease duration of more than 1 year, and extensive alopecia involving more than 50% of the scalp (including AT or AU) suggest a poorer prognosis. Topical corticosteroids a...
Akhtar, Marjahan Basher, Salima Raiyan Nizam, Nuder Nower Hossain, Lazina Bhuiyan, Taufiqur Rahman Qadri, Firdausi Lundgren, Anna
Published in
Frontiers in Immunology
Background Infection with enterotoxigenic Escherichia coli (ETEC) gives rise to IgA antibodies against both the heat labile toxin (LT) and colonization factors (CFs), which are considered to synergistically protect against ETEC diarrhea. Since the development of ETEC-specific long lived plasma cells and memory B cells is likely to be dependent on T...
Nguyen, Kathy-Uyen Zhang, Yunlong Liu, Qihui Zhang, Ran Jin, Xiaohe Taniguchi, Masahiko Miller, Eric S Lindsey, Jonathan S
Published in
Molecules (Basel, Switzerland)
Tolyporphins were discovered some 30 years ago as part of a global search for antineoplastic compounds from cyanobacteria. To date, the culture HT-58-2, comprised of a cyanobacterium-microbial consortium, is the sole known producer of tolyporphins. Eighteen tolyporphins are now known-each is a free base tetrapyrrole macrocycle with a dioxobacterioc...
Huang, Chuan-Chuan Sung, Hsiang-Hsuan Li, Hsiu-Chuan Miaw, Shi-Chuen Kung, John T. Chou, Min-Yuan Wu-Hsieh, Betty A.
Published in
Frontiers in Immunology
Specific anti-CD3 treatment is deemed to be a promising therapy for allograft rejection and type 1 diabetes (T1D). Fc receptor (FcR) reduced-binding antibodies, by avoiding adverse effects of Fc and FcR interaction, have good therapeutic potential. We generated a trivalent anti-mouse-CD3 Collabody, h145CSA, by using a triplex-forming collagen-like ...
Macca, Laura Li Pomi, Federica Ingrasciotta, Ylenia Morrone, Pietro Trifirò, Gianluca Guarneri, Claudio
Published in
Frontiers in Medicine
Psoriasis and hidradenitis suppurativa are chronic inflammatory skin diseases that can develop together, negatively impacting on the patient’s quality of life. We aimed to review the most up-to-date information regarding the epidemiology, pathogenesis, clinical presentation and possible therapeutical choices in patients with both psoriasis and hidr...
Pan, Yuanyuan Yang, Wenjing Tang, Bo Wang, Xiaobo Zhang, Qi Li, Weiping Li, Li
Published in
Frontiers in Immunology
At the turn of the century, researchers discovered a unique subtype of T helper cells that secretes IL-17 and defined it as Th17. The latest study found that Th17 cells play both positive and negative definitive roles in the regulation of antitumor immune responses. Although the function of Th17 in the tumor microenvironment remains poorly understo...
Ozgur, Burcin Aydin Cinar, Suzan Adin Coskunpinar, Ender Yilmaz, Abdullah Altunkanat, Derya Deniz, Gunnur Gurol, Ali Osman Yilmaz, M Temel
Published in
Immunologic research
Th cells play an important role in pathogenesis of type 1 diabetes (T1D). Peripheral blood mononuclear cells were isolated from peripheral blood samples from newly diagnosed (ND), 1-year (1YD), and 5-year T1D (5YD) patients (n:8 of each group), 8 healthy controls (HC), and cultured for 24 h under unstimulated (US) and stimulated conditions. Cell ra...
Itano, Andrea Maslin, Douglas Ramani, Kritika Mehraei, Golbarg Carpenter, Nancy Cormack, Taylor Saghari, Mahdi Moerland, Matthijs Troy, Erin Caffry, Will
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Published in
Frontiers in Medicine
Introduction EDP1815 is a non-colonizing pharmaceutical preparation of a single stain of Prevotella histicola isolated from the duodenum of a human donor. We report here preclinical and clinical studies showing that the action of EDP1815, an orally delivered and gut restricted single strain of commensal bacteria can regulate inflammatory responses ...
Duesman, Samuel J. Ortega-Francisco, Sandra Olguin-Alor, Roxana Acevedo-Dominguez, Naray A. Sestero, Christine M. Chellappan, Rajeshwari De Sarno, Patrizia Yusuf, Nabiha Salgado-Lopez, Adrian Segundo-Liberato, Marisol
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Published in
Frontiers in Immunology
The transforming growth factor receptor III (TβRIII) is commonly recognized as a co-receptor that promotes the binding of TGFβ family ligands to type I and type II receptors. Within the immune system, TβRIII regulates T cell development in the thymus and is differentially expressed through activation; however, its function in mature T cells is uncl...
Ungar, Benjamin Hartzell, Susan Lozano-Ojalvo, Daniel Ghalili, Sabrina Bose, Swaroop Golant, Alexandra K Tan, Kathryn Estrada, Yeriel D Singer, Giselle K Pavel, Ana B
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Published in
Allergy
