Leigh, Robert S Ruskoaho, Heikki J Kaynak, Bogac L
Published in
Archives of toxicology
Reliable in vitro models to assess developmental toxicity of drugs and chemicals would lead to improvement in fetal safety and a reduced cost of drug development. The validated embryonic stem cell test (EST) uses cardiac differentiation of mouse embryonic stem cells (mESCs) to predict in vivo developmental toxicity, but does not take into account t...
Clayton-Smith, Jill Bromley, Rebecca Dean, John Journel, Hubert Odent, Sylvie Wood, Amanda Williams, Janet Cuthbert, Verna Hackett, Latha Aslam, Neelo
...
Published in
Orphanet Journal of Rare Diseases
BackgroundA pattern of major and minor congenital anomalies, facial dysmorphic features, and neurodevelopmental difficulties, including cognitive and social impairments has been reported in some children exposed to sodium valproate (VPA) during pregnancy. Recognition of the increased risks of in utero exposure to VPA for congenital malformations, a...
Nasr Esfahani, Sajedeh Shao, Yue Resto Irizarry, Agnes M Li, Zida Xue, Xufeng Gumucio, Deborah L Fu, Jianping
Published in
Biomaterials
During early post-implantation human embryogenesis, the epiblast (EPI) within the blastocyst polarizes to generate a cyst with a central lumen. Cells at the uterine pole of the EPI cyst then undergo differentiation to form the amniotic ectoderm (AM), a tissue essential for further embryonic development. While the causes of early pregnancy failure a...
El Husseini, Nazem Hales, Barbara F
Published in
Reproductive toxicology (Elmsford, N.Y.)
Hydroxyurea, a ribonucleotide reductase inhibitor, is a potent teratogen in mice, causing severe limb and skeletal defects. The exposure of gestation day nine murine embryos to hydroxyurea elicits an early embryonic stress response that involves activation of the P53 transcription factor. The impact of this P53 activation on the embryotoxicity of h...
Rocca, Meredith Morford, LaRonda L Blanset, Diann L Halpern, Wendy G Cavagnaro, Joy Bowman, Christopher J
Published in
Regulatory toxicology and pharmacology : RTP
Toxicity studies in pregnant animals are not always necessary for assessing the human risk of developmental toxicity of biopharmaceuticals. The growing experience and information on target biology and molecule-specific pharmacokinetics present a powerful approach to accurately anticipate effects of target engagement by biopharmaceuticals using a we...
Schaefer, Christof
Published in
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz
Die Arzneimitteltherapiesicherheit (AMTS) hat bei der Behandlung von Schwangeren höchste Priorität, da ein ungeborener Mensch mitbehandelt und dadurch gesundheitlichen Risiken ausgesetzt wird. Zu vielen Arzneimitteln liegen jedoch keine ausreichenden Daten zum Risiko in der Schwangerschaft vor und es gibt Unsicherheiten bei der Interpretation vorha...
Murray, Kieran E. Moore, Louise O’Brien, Celine Clohessy, Anne Brophy, Caroline Minnock, Patricia FitzGerald, Oliver Molloy, Eamonn S. Mongey, Anne-Barbara Higgins, Shane
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Published in
Irish Journal of Medical Science (1971 -)
BackgroundRheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease which can cause significant disability, morbidity, mortality, and impaired fertility. It commonly affects women of childbearing age. Managing rheumatoid arthritis (RA) in the perinatal period poses challenges. There is concern about the teratogenic effects of many...
Taye, Molla Afework, Mekbeb Fantaye, Wondwossen Diro, Ermias Worku, Alemayehu
Published in
BMC Pediatrics
BackgroundThe early stage of embryo development is extremely vulnerable to various teratogenic factors, leading to congenital anomalies. In Ethiopia, a significant number of babies are born with congenital anomalies, but the risk factors for the anomalies have never been studied. Understanding the specific risk factors for congenital anomalies is v...
Genaro-Mattos, Thiago C Tallman, Keri A Allen, Luke B Anderson, Allison Mirnics, Karoly Korade, Zeljka Porter, Ned A
Published in
Toxicology and applied pharmacology
While antipsychotic medications provide important relief from debilitating psychotic symptoms, they also have significant adverse side effects, which might have relevant impact on human health. Several research studies, including ours, have shown that commonly used antipsychotics such as haloperidol and aripiprazole affect cholesterol biosynthesis ...
Charlton, R. A. Bettoli, V. Bos, H. J. Engeland, A. Garne, E. Gini, R. Hansen, A. V. de Jong-van den berg, L. T. W. Jordan, S. Klungsøyr, K.
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Published in
European Journal of Clinical Pharmacology
PurposePregnancy prevention programmes (PPPs) exist for some medicines known to be highly teratogenic. It is increasingly recognised that the impact of these risk minimisation measures requires periodic evaluation. This study aimed to assess the extent to which some of the data needed to monitor the effectiveness of PPPs may be present in European ...
