Vishwakarma, Keerti Bhatt, Hardik
Published in
Journal of Molecular Modeling
Rising mortality due to cancer has led to the development and identification of newer targets and molecules to cure the disease. Telomerase is one of the attractive targets for design of many chemotherapeutic drugs. This research highlights the designing of novel telomerase inhibitors using ligand-based (3D-QSAR) and structure-based (molecular dock...
Karpova, Radmila Vladimirovna Petrenko, Daria Andreevna Saribekian, Anna Gevorikovna Vedernikov, Andrey Andreevich Magomedagaev, Muslim Magomedovich Gorbunov, Andrey Sergeevich Shiryaev, Artem Anatolevich Rybin, Vladislav Konstatinovich Chernousov, Kirill Fedorovich
Published in
Annals of medicine and surgery (2012)
Hepatic cystadenoma is an urgent problem due to the high risk of malignant transformation. There are both radical and minimally invasive methods of treatment. We present a clinical case describing the successful use of microwave ablation (MWA) in a 72-year-old woman with hepatic cystadenoma. The patient was admitted to the clinic with abdominal dis...
Boniewska-Bernacka, Ewa Pańczyszyn, Anna Klinger, Marian
Published in
Experimental cell research
Telomeres are repetitive nucleoprotein structures located at the ends of chromosomes. Reduction in the number of repetitions causes cell senescence. Cells with high proliferative potential age with each replication cycle. Post-mitotic cells (e.g. cardiovascular cells) have a different aging mechanism. During the aging of cardiovascular system cells...
Fattet, Anne-Julie Toupance, Simon Thornton, Simon N. Monnin, Nicolas Guéant, Jean-Louis Benetos, Athanase Koscinski, Isabelle
Published in
Journal of Ovarian Research
In the context of a continuously increased delay of motherhood and of an increase of the incidence of premature ovarian failure, it is of the greatest interest to dispose of a predictive marker of the duration of the fertility window. Unfortunately, current available markers of women’s fertility (hormonal rates or echography count of small follicle...
Ghareghomi, Somayyeh Ahmadian, Shahin Zarghami, Nosratollah Kahroba, Houman
Published in
Biochimie
Telomerase activity is critical for cancer cells to provide unrestricted proliferation and cellular immortality through maintaining telomeres. Telomerase enzymatic activity is regulatable at the level of DNA, mRNA, post translational modifications, cellular transport and enzyme assembly. More recent studies confirm the interaction of the telomerase...
AlDehaini, Dhuha M B Al-Bustan, Suzanne A Ali, Muhalab E Malalla, Zainab Hasan Abdulla Sater, Mai Giha, Hayder A
Published in
Acta diabetologica
This study aimed to examine the role of plasma telomerase (TE), plasma insulin, patient's age and disease duration in determination of the leucocytes' telomeres length (LTL) in T2DM. Blood samples from Kuwaiti patients with T2DM (110) and non-diabetic subjects (94) were analyzed by SYBR Green Quantitative PCR for estimation of the Absolute Human Te...
Maleki, Masomeh Khelghati, Nafiseh Alemi, Forough Bazdar, Mahtab Asemi, Zatollah Majidinia, Maryam Sadeghpoor, Alireza Mahmoodpoor, Ata Jadidi-Niaragh, Farhad Targhazeh, Nilofar
...
Published in
Life sciences
Aging is a form of a gradual loss of physiological integrity that results in impaired cellular function and ultimately increased vulnerability to disease and death. This process is a significant risk factor for critical age-related disorders such as cancer, diabetes, cardiovascular disease, and neurological conditions. Several mechanisms contribute...
Wang, Song Yan, Wen-Wen He, Min Wei, Dan Long, Zu-Ji Tao, Yi-Ming
Published in
Pharmacological reports : PR
Telomerase plays an essential role in cancer cell proliferation. In this study, we investigated inhibition mechanism of aloe emodin (AE) on three different types of breast cancer cell lines, MDA-MB-453, MDA-MB-231 and MCF-7. The cells were treated with different concentrations of AE. Relative length of telomere and human telomerase reverse-transcri...
Zou, Yongkang Cong, Yu-sheng Zhou, Junzhi
Published in
BMB Reports
Metastasis is the main culprit of the great majority of cancer-related deaths. However, the complicated process of the inva-sion-metastasis cascade remains the least understood aspect of cancer biology. Telomerase plays a pivotal role in bypassing cellular senescence and sustaining the cancer progression by maintaining telomere homeostasis and geno...
Song, Young Shin Park, Young Joo
Published in
Endocrinology and Metabolism
The telomerase reverse transcriptase ( TERT ) gene, which is repressed in most differentiated human cells, can be reactivated by somatic TERT alterations and epigenetic modulations. Moreover, the recruitment, accessibility, and binding of transcription factors also affect the regulation of TERT expression. Reactivated TERT contributes to the develo...
