Keuler, Tim Wolf, Valentina Lemke, Carina Voget, Rabea Braune, Annett Gütschow, Michael
Published in
Bioorganic chemistry
The bile acid pool has a profound impact on human health and disease. The intestinal microbiota initiates the metabolism of conjugated bile acids through a critical first step catalyzed by bacterial bile salt hydrolase (BSH) and provides unique contributions to the diversity of bile acids. There has been great interest in surveying BSH activity. We...
Yang, Jing Tang, Xujiao Liang, Zhu Chen, Mingzhu Sun, Lixin
Published in
Clinical and molecular hepatology
Disrupted bile acid regulation and accumulation in the liver can contribute to progressive liver damage and fibrosis. However, the effects of bile acids on the activation of hepatic stellate cells (HSCs) remain unclear. This study investigated the effects of bile acids on HSC activation during liver fibrosis, and examined the underlying mechanisms....
Dong, Tien S Jacobs, Jonathan P Agopian, Vatche Pisegna, Joseph R Ayoub, Walid Durazo, Francisco Enayati, Pedram Sundaram, Vinay Benhammou, Jihane N Noureddin, Mazen
...
Published in
Digestive diseases and sciences
Hepatocellular carcinoma (HCC) is rapidly increasing in the U.S. and is a leading cause of mortality for patients with cirrhosis. Discovering novel biomarkers for risk stratification of HCC is paramount. We examined biomarkers of the gut-liver axis in a prospective multicenter cohort. Patients with cirrhosis without a history of HCC were recruited ...
Dong, Tien S Jacobs, Jonathan P Agopian, Vatche Pisegna, Joseph R Ayoub, Walid Durazo, Francisco Enayati, Pedram Sundaram, Vinay Benhammou, Jihane N Noureddin, Mazen
...
BackgroundHepatocellular carcinoma (HCC) is rapidly increasing in the U.S. and is a leading cause of mortality for patients with cirrhosis. Discovering novel biomarkers for risk stratification of HCC is paramount. We examined biomarkers of the gut-liver axis in a prospective multicenter cohort.MethodsPatients with cirrhosis without a history of HCC...
Thompson, Robert S Gaffney, Michelle Hopkins, Shelby Kelley, Tel Gonzalez, Antonio Bowers, Samuel J Vitaterna, Martha Hotz Turek, Fred W Foxx, Christine L Lowry, Christopher A
...
Published in
Brain, behavior, and immunity
Chronic disruption of rhythms (CDR) impacts sleep and can result in circadian misalignment of physiological systems which, in turn, is associated with increased disease risk. Exposure to repeated or severe stressors also disturbs sleep and diurnal rhythms. Prebiotic nutrients produce favorable changes in gut microbial ecology, the gut metabolome, a...
Warden, Cassandra Barnett, Joshua M Brantley, Milam A Jr
Published in
Experimental eye research
Previous metabolomics studies from our lab found altered plasma levels of bile acids in patients with age-related macular degeneration (AMD) compared to controls. In this study, we investigated the ability of the bile acid taurocholic acid (TCA) to inhibit features of AMD modeled in vitro. Paraquat was used to induce oxidative stress in HRPEpiC pri...
Goodman, Robbie R Jong, Madelaine K Davies, John E
Published in
Biotechnology advances
To date only small animal models have been employed to assess the effect of mesenchymal stromal cell (MSC) therapy on acute pancreatitis (AP), the most common cause of hospitalization for gastrointestinal diseases worldwide. We outline the challenges inherent in the small animal models of AP. We also point to specific benefits afforded by the adopt...
Staessen, T.W.O. Verdegem, M.C.J. Weththasinghe, P. Schrama, J.W.
This study investigated in rainbow trout (Oncorhynchus mykiss) if dietary bile acid supplementation is effective in restoring hampered fat digestibility related to conditions that enhance fecal bile acid loss (i.e., high dietary non-starch polysaccharide (NSP) level and high feeding level). Four diets were formulated according to a two-by-two facto...
Hyun, Eun-Ju Hasan, Mohammad Nazmul Kang, Sung Hun Cho, Sungpil Lee, Yong-Kyu
Published in
International journal of pharmaceutics
Oral siRNA delivery is an ideal way to translate siRNA therapeutic effects in the clinic due to its ability to be administered in convenient and multiple dosages. However, an effective oral delivery system requires overcoming both a hostile gastrointestinal (GI) environment and non-specific targeting. Here, an HTsRP-NC system is a new oral siRNA de...
Liu, Zhimin Zhang, Zhifeng Huang, Mei Sun, Xiaoping Liu, Bojia Guo, Qiyang Chang, Qingshan Duan, Zhijun
Published in
BMC Gastroenterology
BackgroundPrevious studies have indicated that bile acid is associated with progression of liver cirrhosis. However, the particular role of specific bile acid in the development of liver cirrhosis is not definite. The present study aims to identify the specific bile acid and explore its possible mechanisms in promoting liver cirrhosis.MethodsThirty...
