SARS-CoV-2 and COVID-19: What are our options? Where should we focus our attention on to find new drugs and strategies?
Published in Travel Medicine and Infectious Disease
Identification and expression analysis of miRNA in hybrid snakehead by deep sequencing approach and their targets predic...
...Published in Genomics
MicroRNAs (miRNAs) play important regulatory roles in numerous biological processes, but there is no report on miRNAs of hybrid snakehead. In this study, four independent small RNA libraries were constructed from the spleen, liver kidney and muscle of hybrid snakehead. These libraries were sequenced using deep sequencing technology, as result, a to...
Up-regulation of microRNA targets correlates with symptom severity in Citrus sinensis plants infected with two different...
Published in Planta
Main conclusionmiRNA targets from Citrus sinensis are predicted and validated using degradome data. They show an up-regulation upon infection with CPsV, with a positive correlation between target expression and symptom severity.AbstractSweet orange (Citrus sinensis) may suffer from disease symptoms induced by virus infections, thus resulting in dra...
Five Priority Areas for Improving Medications Development for Alcohol Use Disorder and Promoting Their Routine Use in Cl...
Published in Alcoholism, clinical and experimental research
A repeated cross-sectional study of clinicians’ use of psychotherapy techniques during 5 years of a system-wide effort t...
...Published in Implementation Science
BackgroundLittle work investigates the effect of behavioral health system efforts to increase use of evidence-based practices or how organizational characteristics moderate the effect of these efforts. The objective of this study was to investigate clinician practice change in a system encouraging implementation of evidence-based practices over 5 y...
Data on docking of phytoconstituents of Actinidia deliciosa on dengue viral targets
Published in Data in Brief
Major Phytoconstituents of Actinidia deliciosa were explored for their anti-viral potential against dengue virus (DENV). The docking of these phytoconstituents was performed on 7 viral targets- 4 DENV non structural protein (NS5-SAM binding domain, NS5 RdRp domain, NS3 helicase & NS2B-NS3 protease) and 3 DENV structural proteins (Envelope protein-β...
A comprehensive review of feature based methods for drug target interaction prediction.
Published in Journal of biomedical informatics
Drug target interaction is a prominent research area in the field of drug discovery. It refers to the recognition of interactions between chemical compounds and the protein targets in the human body. Wet lab experiments to identify these interactions are expensive as well as time consuming. The computational methods of interaction prediction help l...
Hurdles to the Development of the “Surgical Home” in the Low-Resource World
Published in Current Anesthesiology Reports
Purpose of ReviewThis chapter assesses the current state of practice of anesthesia in a low-resourced hospital and the hurdles envisaged in the development of perioperative surgical home, PSH, at the Komfo Anokye Teaching Hospital, KATH in Ghana.Recent FindingsIn the PSH model, the patient’s experience of care is coordinated by a Director of Periop...
The emerging role of WISP proteins in tumorigenesis and cancer therapy
Published in Journal of Translational Medicine
Accumulated evidence has demonstrated that WNT1 inducible signaling pathway protein (WISP) genes, which belong to members of the CCN growth factor family, play a pivotal role in tumorigenesis and progression of a broad spectrum of human cancers. Mounting studies have identified that WISP proteins (WISP1-3) exert different biological functions in va...
Prevalence, treatment, and control of dyslipidemia in diabetic participants of two brazilian cohorts: a place far from h...
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SUMMARY OBJECTIVE Diabetes is one of the leading causes of cardiovascular mortality. Over the last years, mortality has decreased significantly, more in individuals with diabetes than in healthy ones. That is mostly due to the control of other cardiovascular risk factors. The objective of our study was to analyze the dyslipidemia control in two dia...
