Asati, Vivek Anant, Arjun Patel, Preeti Kaur, Kamalpreet Gupta, G D
Published in
European journal of medicinal chemistry
Pyrazolopyrimidine scaffold is one of the privileged heterocycles in drug discovery. This scaffold produced numerous biological activities in which anticancer is important one. Previous studies showed its importance in interactions with various receptors such as growth factor receptor, TGFBR2 gene, CDK2/cyclin E and Abl kinase, adenosine receptor, ...
Pradeep, H. Najma, Umme Aparna, H. S.
Published in
The Protein Journal
The COVID-19, an acute respiratory syndrome caused by SARS-CoV2 is a major catastrophic event of the twenty first century. Relentless efforts for the development of effective pharmaco-therapeutics are in progress but the respite is the development of effective vaccines. However, monotherapy might not always exhibit complete efficacy and may culmina...
Hamblin, Richard Shuker, Carl
Published in
International journal of health policy and management
Tenbensel and colleagues identify that a target for emergency department (ED) stays in New Zealand met with gaming in response from local hospitals. The result is in line with studies in other jurisdictions. The enthusiasm for targets and tight performance measurement in some health systems reflects a lack of trust in professionals to do the right ...
Pang, Jing Sullivan, David R Hare, David L Colquhoun, David M Bates, Timothy R Ryan, Jacqueline D M Bishop, Warrick Burnett, John R Bell, Damon A Simons, Leon A
...
Published in
Heart, lung & circulation
Familial hypercholesterolaemia (FH) is under-diagnosed and under-treated worldwide, including Australia. National registries play a key role in identifying patients with FH, understanding gaps in care and advancing the science of FH to improve care for these patients. The FH Australasia Network has established a national web-based registry to raise...
Mirkuzie, Alemnesh H. Ali, Solomon Abate, Ebba Worku, Asnake Misganaw, Awoke
Published in
BMC Public Health
BackgroundSustainable Development Goal (SDG) 3.3, targets to eliminate HIV from being a public health threat by 2030. For better tracking of this target interim Fast Track milestones for 2020 and composite complementary measures have been indicated. This study measured the Fast Track progress in the epidemiology of HIV/AIDS in Ethiopia across ages ...
Rhodes, Tim Lancaster, Kari
Published in
The International journal on drug policy
The field of public health is replete with mathematical models and numerical targets. In the case of disease eliminations, modelled projections and targets play a key role in evidencing elimination futures and in shaping actions in relation to these. Drawing on ideas within science and technology studies, we take hepatitis C elimination as a case f...
Khan, Muhammad Tahir Irfan, Muhammad Ahsan, Hina Ahmed, Abrar Kaushik, Aman Chandra Khan, Anwar Sheed Chinnasamy, Sathishkumar Ali, Arif Wei, Dong-Qing
Published in
Intervirology
Background: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) epidemic has resulted in thousands of infections and deaths worldwide. Several therapies are currently undergoing clinical trials for the treatment of SARS-CoV-2 infection. However, the development of new drugs and the repositioning of existing drugs can only be achieved a...
Grimm, Daniela Bauer, Johann Wise, Petra Krüger, Marcus Simonsen, Ulf Wehland, Markus Infanger, Manfred Corydon, Thomas J
Published in
Seminars in cancer biology
Cancer is a heavy burden for humans across the world with high morbidity and mortality. Transcription factors including sex determining region Y (SRY)-related high-mobility group (HMG) box (SOX) proteins are thought to be involved in the regulation of specific biological processes. The deregulation of gene expression programs can lead to cancer dev...
Rawat, Kajal Kumari, Puja Saha, Lekha
Published in
European journal of pharmacology
Coronavirus Disease 2019 named as COVID-19 imposing a huge burden on public health as well as global economies, is caused by a new strain of betacoronavirus named as SARS-CoV-2. The high transmission rate of the virus has resulted in current havoc which highlights the need for a fast and effective approach either to prevent or treat the deadly infe...
Claudia, Cervantes-Durán María-Elena, Velázquez-Hernández Josué, Valentín-Escalera María-Carmen, Bartolomé-Camacho Alain-Raimundo, Rodríguez-Orozco Martha-Estrella, García-Pérez
Published in
Archives of dermatological research
Psoriasis is an incurable cutaneous illness characterized by the presence of well-delimited reddish plaques and silvery-white dry scales. So far, there is a limited understanding of its pathogenesis, though recent discoveries on the immunological, genetic and molecular aspects of this disease have significantly contributed to the identification of ...
