guillaume, philippe rupp, tristan froget, guillaume goineau, sonia
Psoriasis is a chronic inflammatory skin disorder characterized by keratinocyte hyperproliferation, inflammation, and aberrant differentiation. Imiquimod-induced psoriasis in rodent models has been widely used to study the pathogenesis of the disease and evaluate potential therapeutic interventions. In this study, we investigated the efficacy of tw...
Noche, Jessica A Radhakrishnan, Hamsanandini Ubele, Margo F Boaz, Kathy Mefford, Jennifer L Jones, Erin D van Rooyen, Hollie Y Perpich, Jessica A McCarty, Katie Meacham, Beverly
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Aging dogs serve as a valuable preclinical model for Alzheimer's disease (AD) due to their natural age-related development of β-amyloid (Aβ) plaques, human-like metabolism, and large brains that are ideal for studying structural brain aging trajectories from serial neuroimaging. Here we examined the effects of chronic treatment with the calcineurin...
Schäfer, Sabine C Voll, Andreas M Bracher, Andreas Ley, Steven V Hausch, Felix
Antascomicin B is a natural product that similarly to the macrolides FK506 and Rapamycin binds to the FK506-binding protein 12 (FKBP12). FK506 and Rapamycin act as molecular glues by inducing ternary complexes between FKBPs and additional target proteins. Whether Antascomicin B can induce ternary complexes is unknown. Here we show that Antascomicin...
Jiang, Zhenwei Xu, Caomei Hou, Huan Yang, Xuping Qian, Minyan Zuo, Lian Wang, Peipei Qian, Qing Jiang, Yan Hu, Nan
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Published in
Annals of Transplantation
Background This study aimed to investigate the incidence of post-transplant diabetes mellitus (PTDM) in renal transplant (RT) patients at our center and to explore new risk factors for PTDM. Material/Methods This retrospective study included RT patients from 2010 to 2022. Clinic data on RT patients were obtained from hospital electronic medical rec...
Teixidó-Trujillo, Silvia Porrini, Esteban Menéndez-Quintanal, Luis Manuel Torres-Ramírez, Armando Fumero, Cecilia Rodríguez-Rodríguez, Ana Elena
Published in
Frontiers in Endocrinology
Introduction The pathogenesis of Post-Transplant Diabetes Mellitus (PTDM) is complex and multifactorial and it resembles that of Type-2 Diabetes Mellitus (T2DM). One risk factor specific to PTDM differentiates both entities: the use of immunosuppressive therapy. Specifically, Tacrolimus interacts with obesity and insulin resistance (IR) in accelera...
Liu, Dorothy Youssef, Mark M Grace, Josephine A Sinclair, Marie
Published in
World Journal of Hepatology
BACKGROUND De novo malignancy is a leading cause of late morbidity and mortality in liver transplant recipients. Cumulative immunosuppression has been shown to contribute to post-transplant malignancy (PTM) risk. There is emerging evidence on the differential carcinogenic risk profile of individual immunosuppressive drugs, independent of the net ef...
Boland, Lidvine Devresse, Arnaud Monchaud, Caroline Briol, Sébastien Belaiche, Stéphanie Giguet, Baptiste Couzi, Lionel Thaunat, Olivier Esposito, Laure Meszaros, Magdalena
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Published in
Transplant International
Gwinner, Wilfried Anaokar, Swapneel Blogg, Martin Hermann, Birgit Repetur, Carola del Pilar Schiffer, Mario
Published in
Annals of Transplantation
Background Long-term real-world outcomes data for kidney transplant recipients (KTRs) converting from immediate-release tacrolimus (IRT) to prolonged-release tacrolimus (PRT) are limited. Material/Methods A retrospective, non-interventional review of adult KTRs treated with PRT for ≥1 month was conducted in Germany. Data were extracted from time of...
Lo, Chien-Ming Chen, Wei-Hsun Tsai, Meng-Yun Lu, Hung-I Hsiao, Yu-Hsin Chuang, Kai-Hao Chen, Yu Wu, Hsuan-Feng Huang, Kuo-Tung Wang, Yi-Hsi
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Published in
Journal of Cardiothoracic Surgery
Background Coronavirus disease 2019 (COVID-19) infection in lung transplant recipients can be lethal owing to the use of immunosuppressants. Antiviral agents may be administered to these patients. Co-packaged nirmatrelvir-ritonavir is a new agent currently being used in combination. Case presentation In this report, we present a case of a 64-year-o...
Wiseman, Alexander Alhamad, Tarek Alloway, Rita R. Concepcion, Beatrice P. Cooper, Matthew Formica, Richard Klein, Christina L. Kumar, Vineeta Leca, Nicolae Shihab, Fuad
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Published in
Annals of Transplantation
Background LCPT (Envarsus XR®) is a common once-daily, extended-release oral tacrolimus formulation used in kidney transplantation. However, there are minimal evidence-based recommendations regarding optimal dosing and treatment in the de novo and conversion settings. Material/Methods Using Delphi methodology, 12 kidney transplantation experts with...
