Verhoeven, Jeroen Bolcaen, Julie De Meulenaere, Valerie Kersemans, Ken Descamps, Benedicte Donche, Sam Van den Broecke, Caroline Boterberg, Tom Kalala Okito, Jean-Pierre Deblaere, Karel
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Background: Glioblastoma (GB) is the most common primary malignant brain tumor. Standard medical treatment consists of a maximal safe surgical resection, subsequently radiation therapy (RT) and chemotherapy with temozolomide (TMZ). An accurate definition of the tumor volume is of utmost importance for guiding RT. In this project we investigated the...
Weber, Marc-André Papakonstantinou, Olympia Nikodinovska, Violeta Vasilevska Vanhoenacker, Filip
Ewing's sarcoma (ES) is a rare, highly malignant anaplastic stem cell tumor. Histologically, the tumor consists of uniform densely packed small monomorphic cells with round nuclei. The typical appearance at hematoxylin and eosin (H&E) staining is small blue round cells without any matrix formation. On conventional radiography, ES typically presents...
Mishchenko, Tatiana Mitroshina, Elena Balalaeva, Irina Krysko, Olga Vedunova, Maria Krysko, Dmitri
In the last decade, it has become clear that anti-cancer therapy is more successful when it can also induce an immunogenic form of cancer cell death (ICD). ICD is an umbrella term covering several cell death modalities, including apoptosis and necroptosis. In general, ICD is characterized by the emission of damage-associated molecular patterns (DAM...
Posadzy, Magdalena Vanhoenacker, Filip Siozopoulou, Vasiliki
Juxta-cortical chondroma is a rare cartilaginous tumor originating from the periosteum. On conventional radiography, the lesion typically causes saucerization of the adjacent cortex with well-delineated sclerotic margins. Projection radiography may be less accurate than cross-sectional imaging to demonstrate the precise extent of pressure erosion a...
Visser, Nicole CM van der Putten, Louis JM van Egerschot, Alex Van de Vijver, Koen Santacana, Maria Bronsert, Peter Hirschfeld, Marc Colas, Eva Gil-Moreno, Antonio Garcia, Angel
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Frilling, A Clift, AK Braat, AJAT Alsafi, A Wasan, HS Al-Nahhas, A Thomas, R Drymousis, P Habib, N Tait, PN
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BACKGROUND: Neuroendocrine liver metastases are clinically challenging due to their frequent disseminated distribution. This study aims to present a British experience with an emerging modality, radioembolisation with yttrium-90 labelled microspheres, and embed this within a meta-analysis of response and survival outcomes. METHODS: A retrospective ...
GAHOI, N MALHOTRA, D MOIYADI, A VARMA, SG GANDHI, MN SRIVASTAVA, S
PurposeGliomas are one of the most aggressive and lethal brain tumors arising from neoplastic transformation of astrocytes and oligodendrocytes. A comprehensive quantitative analysis of proteome level differences in cerebrospinal fluid (CSF) across different grades of gliomas for a better understanding of glioma pathobiology is carried out. Experim...
Capdevila, Jaume Bodei, Lisa Davies, Philippa Gorbounova, Vera Jensen, Robert T. Knigge, Ulrich P. Krejs, Guenter J. Krenning, Eric O’Connor, Juan Manuel Peeters, Marc
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Published in
Neuroendocrinology
Unmet medical needs are not infrequent in oncology, and these needs are usually of higher magnitude in rare cancers. The field of neuroendocrine neoplasms (NENs) has evolved rapidly during the last decade, and, currently, a new WHO classification is being implemented and several treatment options are available in the metastatic setting after the re...
Sorbye, H Baudin, E Borbath, I Caplin, M Chen, J Cwikla, J Frilling, A Grossman, A Kaltsas, G Scarpa, A
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Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are classified based upon morphology and graded upon proliferation rate as either well-differentiated low-grade (G1-G2) neuroendocrine tumours (NET) or poorly differentiated high-grade (G3) neuroendocrine carcinoma (NEC). Recently, a new subgroup of well-differentiated high-grade pancreati...
Garas, George Arora, Asit
Published in
ORL
The first application of robotic technology in surgery was described in 1985 when a robot was used to define the trajectory for a stereotactic brain biopsy. Following its successful application in a variety of surgical operations, the da Vinci® robot, the most widely used surgical robot at present, made its clinical debut in otorhinolaryngology and...