Choi, Yujin Jung, In-Chul Kim, Ae-Ran Park, Hyo-Ju Kwon, Ojin Lee, Jun-Hwan Kim, Joo-Hee
Published in
Brain sciences
Although Electroacupuncture (EA) has been reported to be potentially effective for cognitive disorders, there is limited information about which domains of cognitive function can be improved by EA treatment. Sixty patients with MCI were randomly assigned (1:1:1) to groups to receive 24 sessions over 12 weeks of EA, sham EA, or usual care. In the EA...
Wei, Pengliang Demulder, Manon David, Pascale Eekhout, Thomas Yoshiyama, Kaoru Okamoto Nguyen, Long Vercauteren, Ilse Eeckhout, Dominique Galle, Margot De Jaeger, Geert
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Aluminum (Al) toxicity and inorganic phosphate (Pi) limitation are widespread chronic abiotic and mutually enhancing stresses that profoundly affect crop yield. Both stresses strongly inhibit root growth, resulting from a progressive exhaustion of the stem cell niche. Here, we report on a casein kinase 2 (CK2) inhibitor identified by its capability...
Ronda, Onne AHO; 138409; van de Heijning, Bert JM; de Bruin, Alain; Thomas, Rachel E; Martini, Ingrid; Koehorst, Martijn; Gerding, Albert; Koster, Mirjam H; Bloks, Vincent W; Jurdzinski, Angelika;
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Mouse models are frequently used to study mechanisms of human diseases. Recently, we observed a spontaneous bimodal variation in liver weight in C57BL/6JOlaHsd mice fed a semisynthetic diet. We now characterized the spontaneous variation in liver weight and its relationship with parameters of hepatic lipid and bile acid (BA) metabolism. In male C57...
Rayment, Diana; Peters, Richard; Marston, Linda; De Groef, Bert; 129736;
Previously identified correlations between circulating cortisol and serotonin levels with aggressive, fearful or impulsive behavior in dogs have led to the suggestion that these measures be assessed as screening tools to aid in the identification of individual dogs with aggressive or fearful tendencies in applied settings, such as shelters or breed...
Zhou, L Wen, Z Wang, Z Zhang, Y Ledesma-Amaro, R Jin, M
The recombinant strain Y. lipolytica XYL+ can utilize xylose to produce microbial lipids efficiently. However, its xylose uptake is severely delayed in the presence of d-glucose. In this study, adaptive laboratory evolution (ALE) of strains in the medium containing xylose and d-glucose analogue 2-deoxyglucose (dG) is performed. After four stages of...
Haylock, S Friddin, M Hindley, J Rodriguez, E Charalambous, K Booth, P Barter, L Ces, O
Droplet interface bilayers (DIBs) are model membranes formed between lipid monolayer-encased water droplets in oil. Compared to conventional methods, one of the most unique properties of DIBs is that they can be connected together to generate multi-layered ‘tissue-like’ networks, however introducing communication pathways between these compartments...
Dickinson, Laura Gurjar, Rohan Stöhr, Wolfgang Bonora, Stefano Owen, Andrew D'Avolio, Antonio Cursley, Adam Molina, Jean-Michel Fäetkenheuer, Gerd Vandekerckhove, Linos
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Published in
The Journal of antimicrobial chemotherapy
NEAT001/ANRS143 demonstrated non-inferiority of once-daily darunavir/ritonavir (800/100 mg) + twice-daily raltegravir (400 mg) versus darunavir/ritonavir + tenofovir disoproxil fumarate/emtricitabine (245/200 mg once daily) in treatment-naive patients. We investigated the population pharmacokinetics of darunavir, ritonavir, tenofovir and emtricitab...
Pauwelyn, Glenn Vlerick, Lise Dockx, Robrecht Verhoeven, Jeroen Dobbeleir, Andre Bosmans, Tim Peremans, Kathelijne Vanhove, Christian Polis, Ingeborgh De Vos, Filip
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Published in
BMC Veterinary Research
BackgroundCurrently, [18F] altanserin is the most frequently used PET-radioligand for serotonin2A (5-HT2A) receptor imaging in the human brain but has never been validated in dogs. In vivo imaging of this receptor in the canine brain could improve diagnosis and therapy of several behavioural disorders in dogs. Furthermore, since dogs are considered...
Padmakumar, Manisha; Van Raes, Eveline; Van Geet, Chris; 10892; Freson, Kathleen; 2969;
Autism spectrum disorder (ASD) is a clinically heterogeneous neurodevelopmental disorder that is caused by gene-environment interactions. To improve its diagnosis and treatment, numerous efforts have been undertaken to identify reliable biomarkers for autism. None of them have delivered the holy grail that represents a reproducible, quantifiable, a...
Wilson, H Dervenoulas, G Pagano, G Koros, C Yousaf, T Picillo, M Polychronis, S Simitsi, A Giordano, B Chappell, Z
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BACKGROUND: Because of the highly penetrant gene mutation and clinical features consistent with idiopathic Parkinson's disease, carriers of the autosomal dominant Ala53Thr (A53T; 209G→A) point mutation in the α-synuclein (SNCA) gene are an ideal population to study the premotor phase and evolution of Parkinson's pathology. Given the known neurochem...
