The respiratory tract is the route of entry for accidentally inhaled AgNPs, which can reach the lungs and redistribute to other main organs through systemic circulation. In the present work, we aimed to evaluate silver biodistribution and biological effects after 1 or 2 intratracheal instillations (IT) of two differently sized PVP-coated AgNPs (5 a...
Cytochrome c Oxidase (CcO) is the terminal electron acceptor in aerobic respiratory chain, reducing O-2 to water. The released free energy is stored by pumping protons through the protein, maintaining the transmembrane electrochemical gradient. Protons are held transiently in a proton loading site (PLS) that binds and releases protons driven by the...
status: published
The ability to sense proteins and protein‐related interactions at the single‐molecule level is becoming of increasing importance to understand biological processes and diseases better. Single‐molecule sensors, such as nanopores have shown substantial promise for the label‐free detection of proteins; however, challenges remain due to the lack of sel...
Diet has important effects on normal physiology and the potential deleterious effects of high fat diets and obesity on male reproductive health are being increasingly described. We conducted a histological review of the effects of chronic high fat (HF) diet (using a mouse model fed a 45% fat diet for 21 weeks) with a discovery proteomic study to as...
BACKGROUND: Late onset sepsis (LOS) in preterm infants is preceded by fecal volatile organic compound (VOC) alterations, suggesting an etiologic role of gut microbiota in LOS rather than being primarily caused by central venous catheters (CVC). To increase our knowledge about the involvement of the gut microbiota in LOS, we analyzed fecal samples f...
The kinetics of Se uptake and toxicity to Lemna were studied over a period of 14 days of exposure to Se(IV) or Se(VI). The growth of Lemna stopped immediately after exposure to 5.0 mg/L of Se(IV) or Se(VI). The content of chlorophyll and phaeopigments of Lemna exposed to 5.0 mg/L of Se(IV) was 2–3 times less than in the control after 3 d exposure. ...
The emergence of novel sequencing technologies has greatly improved the identification of structural variation, revealing that a human genome harbors tens of thousands of structural variants (SVs). Since these SVs primarily impact noncoding DNA sequences, the next challenge is one of interpretation, not least to improve our understanding of human d...
Graphene family nanomaterials (GFNs) have experienced significant development in recent years and have been used in many fields. Despite the benefits, they bring to society and the economy, their potential for posing environmental and health risks should also be considered. The increasing release of GFNs into the ecosystem is one of the key environ...
Graphene family nanomaterials (GFNs) have experienced significant development in recent years and have been used in many fields. Despite the benefits, they bring to society and the economy, their potential for posing environmental and health risks should also be considered. The increasing release of GFNs into the ecosystem is one of the key environ...
