Introduction: In the treatment of dermatological disorders, topical drug administration is a mainstay. However, nanoparticle-based carrier systems could improve and expand the current therapeutic range via localized delivery of active ingredients. Areas covered: This review gives a detailed description of lipid-and surfactant-based drug delivery sy...
Geusens, BarbaraVan Gele, MireilleBraat, SienDe Smedt, StefaanStuart, Marc CAProw, Tarl WSanchez, WashingtonRoberts, Michael SSanders, NiekLambert, Jo
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The extent to which nanoscale-engineered systems cross intact human skin and can exert pharmacological effects in viable epidermis is controversial. This research seeks to develop a new lipid-based nanosome that enables the effective delivery of siRNA into human skin. The major finding is that an ultrafl exible siRNA-containing nanosome—prepared us...
