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with TLR2 signaling as keyword
Bono, Cristina Guerrero, Paula Erades, Ana Jordán-Pla, Antonio Yáñez, Alberto Gil, María Luisa
Published in
Stem cells (Dayton, Ohio)
During an infection, hematopoiesis is altered to increase the output of mature myeloid cells to fight off the pathogen. Despite convincing evidence that hematopoietic stem and progenitor cells (HSPCs) can sense pathogens directly, more mechanistic studies are needed to reveal whether pattern recognition receptor (PRR) signaling initiates myeloid de...
Chen, Xuqin Meng, Xiangying Foley, Niamh M Shi, Xiaoyan Liu, Min Chai, Yahui Li, Yiping Redmond, H Paul Wang, Jian Wang, Jiang Huai
...
Published in
Journal of neuroimmunology
It has been reported that B7-H3, a costimulatory protein, participates in the development and progression of experimental pneumococcal meningitis by amplifying the TLR2-mediated inflammatory response. This study attempted to clarify the pathway(s) of TLR2 signaling involved in B7-H3-augmented inflammatory response during S. pneumoniae infection. Mu...
Makkawi, Hasnaa Hoch, Shifra Burns, Elia Hosur, Kavita Hajishengallis, George Kirschning, Carsten J. Nussbaum, Gabriel
Published in
Frontiers in Cellular and Infection Microbiology
Porphyromonas gingivalis is a gram-negative anaerobic periodontal pathogen that persists in dysbiotic mixed-species biofilms alongside a dense inflammatory infiltrate of neutrophils and other leukocytes in the subgingival areas of the periodontium. Toll-like receptor 2 (TLR2) mediates the inflammatory response to P. gingivalis and TLR2-deficient mi...
Xie, Yafeng Xu, Man Xiao, Yongjian Liu, Zhuoran Jiang, Chuanhao Kuang, Xingxing Wang, Chuan Wu, Haiying Peng, Jing Li, Chun
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Published in
Molecular immunology
Treponema pallidum subsp. pallidum membrane proteins are considered as potent inducers in the initiation and development of inflammation. In the present study, the mechanism that leads to the production of interleukin 6 (IL-6), one of the key proinflammatory cytokines, by human monocytic THP-1 cells when these cells are treated with T. pallidum fla...
