Jisr, Nazek Younes, Ghassan El Omari, Khaled Hamze, Monzer Sukhn, Carol El-Dakdouki, Mohammad H.
Published in
Environmental Monitoring and Assessment
The present study aimed at evaluating the levels of microbiological contamination, total petroleum hydrocarbons (TPHs), and heavy metals (As, Cd, Hg, and Pb) in the edible tissues of commonly consumed fish (8 species) collected from the marine area of Tripoli, Northern Lebanon. Total coliform levels in all sampled fish, and Escherichia coli levels ...
Camacho, Oscar M Hedge, Andrew Lowe, Frazer Newland, Nik Gale, Nathan McEwan, Mike Proctor, Christopher
Published in
Contemporary clinical trials communications
Tobacco harm reduction strategies aim to substitute smoking with potentially reduced risk products (PRRPs) such as e-cigarettes and tobacco-heating products (THPs). The health benefits of switching from smoking to PRRPs is unknown. A randomised controlled trial is being conducted to increase understanding of the health effects of switching from smo...
Devos, Perrine Haddad, Mathieu Carrère, Hélène
he increasing demand for a Thermal Hydrolysis Process (THP) to pretreat municipal sludge upstream Anaerobic Digestion (AD) opens the opportunity to further develop and optimise this technology. The optimal THP temperature remains unclear due to the production of refractory compounds at high temperature. A compilation of literature data was conducte...
Thorne, David Leverette, Robert Breheny, Damien Lloyd, Mel McEnaney, Stephen Whitwell, James Clements, Julie Bombick, Betsy Gaça, Marianna
Published in
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
In this study, a variety of test matrices from tobacco and nicotine delivery products were assessed against a 3R4F Kentucky reference cigarette using the in vitro micronucleus assay. Testing was conducted using two Chinese hamster cell lines (CHO and V79), and a human lymphoblastoid cell line (TK6), in accordance with established guidelines. Total ...
Yu, Wensheng Hu, Bin Zhong, Bin Hao, Jinglai Lei, Zhixin Agrawal, Sony Rokosz, Laura Liu, Rong Chen, Shiying Asante-Appiah, Ernest
...
Published in
Bioorganic & medicinal chemistry letters
A series of novel tetracyclic core-containing HCV NS5A inhibitors has been discovered. Incorporation of tetrahydropyran-substituted amino acid moiety improved their potency and yielded HCV NS5A inhibitors with a minimum potency shift from the GT1a strain compared to other genotypes and mutants. Compounds 53 and 54 showed the best potency profile an...
Zhou, Qidong Ding, Weihong Weng, Yingjie Ding, Guanxiong Xia, Guowei Xu, Jianfeng Xu, Ke Ding, Qiang
Published in
Chemotherapy
Objectives: To analyze the correlation between pharmacogenomic biomarkers and the efficacy of pirarubicin (THP, also named 4’-O-tetrahydropyranyl-adriamycin) and to explore potential associations of individual genetic backgrounds with the clinical outcomes of non-muscle-invasive bladder cancer (NMIBC) patients. Methods: Between July 2003 and June 2...
Tosukhowong, Piyaratana Kulpradit, Pimsuda Chaiyarit, Sakdithep Ungjareonwattana, Wattanachai Kalpongnukul, Nuttiya Ratchanon, Supoj Thongboonkerd, Visith
Published in
Urolithiasis
Our previous study has shown that lime powder (LP) had an inhibitory effect against calcium oxalate stone formation. However, the precise mechanisms underlying such beneficial effect remained unclear. Our present study thus aimed to address the effect of LP on excretory level and compositions of urinary proteins using a proteomics approach. From a ...
Su, Qiongli Tao, Ting Tang, Lei Deng, Jun Darko, Kwame Oteng Zhou, Sichun Peng, Mei He, Shanping Zeng, Qing Chen, Alex F
...
Published in
Journal of cellular and molecular medicine
Pyruvate kinase M2 (PKM2) regulates the final step of glycolysis levels that are correlated with the sensitivity of anticancer chemotherapeutic drugs. THP is one of the major drugs used in non-muscle-invasive bladder cancer instillation chemotherapy. However, low response ratio of THP (19.7%) treatment to human genitourinary tumours using collagen ...
Svensson, Kine Kjørlaug, Oda Higgins, Matthew J Linjordet, Roar Horn, Svein J
Published in
Water research
Post-anaerobic digestion (PAD) treatment technologies have been suggested for anaerobic digestion (AD) to improve process efficiency and assure hygenization of organic waste. Because AD reduces the amount of organic waste, PAD can be applied to a much smaller volume of waste compared to pre-digestion treatment, thereby improving efficiency. In this...
Adamson, Jason Jaunky, Tomasz Thorne, David Gaça, Marianna D
Published in
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Traditional in vitro exposure to combustible tobacco products utilise exposure systems that include the use of smoking machines to generate, dilute and deliver smoke to in vitro cell cultures. With reported lower emissions from next generation tobacco and nicotine products (NGPs), including e-cigarettes and tobacco heating products (THPs), diluting...
