Gupta, Anamika Qaisar, Rizwan Halwani, Rabih Kannan, Meganathan Ahmad, Firdos
Published in
Experimental biology and medicine (Maywood, N.J.)
D-dimer is an established biomarker of thromboembolism and severity in COVID-19. We and others have recently reported the dysregulation of tissue factor pathway inhibitor (TFPI), FXIII, fibrinolytic pathway, inflammatory markers, and tissue injury markers, particularly in severe COVID-19. However, association of these markers with thromboembolism i...
Didembourg, Marie Douxfils, Jonathan Carlo, Audrey Mullier, François Hardy, Michael Morimont, Laure
Published in
International journal of laboratory hematology
Hansen, C H Cwikiel, J Bratseth, V Arnesen, H Flaa, A Seljeflot, I
Published in
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
We examined whether resting levels and exercise-induced changes during exercise ECG stress test (EST) of cardiac Troponin T (cTnT), NT-proBNP and prothrombotic markers were affected by revascularization in patients with coronary artery disease (CAD).EST1 was performed before coronary angiography and revascularization, and patients (n = 20) with con...
Ma, Jiewen Sun, Wengang Tang, Liang Yang, Di
Published in
Frontiers in Medicine
We report a case of Behçet’s disease (BD) with a newly identified tissue factor pathway inhibitor (TFPI) gene mutation. The patient suffered from recurrent deep vein thrombosis and dural sinus thrombosis which could not be relieved by constant anticoagulation therapy. Slight relapsing oral lesion was the initial manifestation of BD but was neglecte...
Behzadifard, Mahin Soleimani, Masoud
Published in
Thrombosis Journal
Background Coronavirus disease 2019 (COVID-19) infection is related to immune hyperactivity, the release of inflammatory cytokines, and immunothrombosis. Among the underlying mechanisms in COVID-19 thrombosis, neutrophil extracellular traps (NETs) formation, NETosis, may have a significant role. COVID-19 thrombi obtained from extracorporeal membran...
Miura, Shuhei Habibabady, Zahra A Pollok, Franziska Connolly, Margaret Pratts, Shannon Dandro, Amy Sorrells, Lori Karavi, Kasinath Phelps, Carol Eyestone, Will
...
Published in
Xenotransplantation
Loss of barrier function when GalTKO.hCD46 porcine lungs are perfused with human blood is associated with coagulation pathway dysregulation, innate immune system activation, and rapid sequestration of human formed blood elements. Here, we evaluate whether genetic expression of human tissue factor pathway inhibitor (hTFPI) and human CD47 (hCD47), al...
Kee, Zizheng Ong, Sze Min Heng, Chew-Kiat Ooi, Delicia Shu Qin
Published in
Journal of molecular medicine (Berlin, Germany)
The first genome-wide association study on coronary artery disease (CAD) in the Han Chinese population identified C6orf105 as a susceptibility gene. The C6orf105 gene was later found to encode for a protein that regulates tissue factor pathway inhibitor (TFPI) expression in endothelial cells in an androgen-dependent manner, and the novel protein wa...
Wang, Guanghua Xie, Bing Su, Yanli Gu, Qinqin Hao, Dongfang Liu, Hongmei Wang, Changbiao Hu, Yonghua Zhang, Min
Published in
Veterinary Research
Tissue factor pathway inhibitors (TFPI), including TFPI-1 and TFPI-2, are Kunitz-type serine protease inhibitors that mainly inhibit the blood coagulation induced by tissue factors. Previous reports on teleost proved TFPI play important roles in innate immunity. In this study, two TFPI (PoTFPI-1 and PoTFPI-2) molecules from Japanese flounder (Paral...
Kee, Zizheng Ong, Sze Min Heng, Chew-Kiat Ooi, Delicia Shu Qin
10.1007/s00109-021-02160-5 / JOURNAL OF MOLECULAR MEDICINE-JMM / 100 / 2 / 185-196 / completed
Keyloun, John W Le, Tuan D Pusateri, Anthony E Ball, Robert L Carney, Bonnie C Orfeo, Thomas Brummel-Ziedins, Kathleen E Bravo, Maria C McLawhorn, Melissa M Moffatt, Lauren T
...
Published in
Shock (Augusta, Ga.)
The aim of this study is to evaluate the association between burn injury and admission plasma levels of Syndecan-1 (SDC-1) and Tissue Factor Pathway Inhibitor (TFPI), and their ability to predict 30-day mortality. SDC-1 and TFPI are expressed by vascular endothelium and shed into the plasma as biomarkers of endothelial damage. Admission plasma biom...
