Wang, Yaqiang Gallagher-Jones, Marcus Sušac, Lukas Song, He Feigon, Juli
Published in
Proceedings of the National Academy of Sciences of the United States of America
Telomerase is a ribonucleoprotein complex that counteracts the shortening of chromosome ends due to incomplete replication. Telomerase contains a catalytic core of telomerase reverse transcriptase (TERT) and telomerase RNA (TER). However, what defines TERT and separates it from other reverse transcriptases remains a subject of debate. A recent cryo...
Zhang, Han-Wen Lyu, Gui-Wen He, Wen-Jie Lei, Yi Lin, Fan Wang, Meng-Zhu Zhang, Hong Liang, Li-Hong Feng, Yu-Ning Yang, Ji-Hu
...
Published in
Academic radiology
The World Health Organization 2016 classification of central nervous system tumors added the molecular classification of gliomas and has guiding significance for the operation and prognosis of glioma patients. At present, the perfusion technique plays an important role in judging the malignant degree of glioma. To evaluate the performance of dynami...
Kawashima, Masumi Ueda, Yuka Kurihara, Sho Hiyama, Eiso
Published in
International journal of clinical oncology
Unfavorable neuroblastomas (NBLs) achieve telomere stabilization via telomerase activation through MYCN amplification, TERT promoter region (TERT-PR) rearrangements, or alternative telomere lengthening of telomeres. No well-established methods are available for investigating TERT-PR rearrangements. We examined the relationship between and prognosis...
Jiang, Xiaoxue Wang, Liyan Xie, Sijie Chen, Yingjie Song, Shuting Lu, Yanan Lu, Dongdong
Published in
Stem Cell Research & Therapy
BackgroundMEG3 downregulated the expression in several tumors and inhibits human tumorigenesis. But so far, the mechanism of MEG3 in tumorigenesis is still unclear.MethodsIn gene infection, cellular and molecular technologies and tumorigenesis test in vitro and in vivo were performed, respectively.ResultsOur results indicate that MEG3 enhances the ...
Arita, Hideyuki Matsushita, Yuko Machida, Ryunosuke Yamasaki, Kai Hata, Nobuhiro Ohno, Makoto Yamaguchi, Shigeru Sasayama, Takashi Tanaka, Shota Higuchi, Fumi
...
Published in
Acta Neuropathologica Communications
TERT promoter mutations are commonly associated with 1p/19q codeletion in IDH-mutated gliomas. However, whether these mutations have an impact on patient survival independent of 1p/19q codeletion is unknown. In this study, we investigated the impact of TERT promoter mutations on survival in IDH-mutated glioma cases. Detailed clinical information an...
Ghareghomi, Somayyeh Ahmadian, Shahin Zarghami, Nosratollah Kahroba, Houman
Published in
Biochimie
Telomerase activity is critical for cancer cells to provide unrestricted proliferation and cellular immortality through maintaining telomeres. Telomerase enzymatic activity is regulatable at the level of DNA, mRNA, post translational modifications, cellular transport and enzyme assembly. More recent studies confirm the interaction of the telomerase...
Mefford, Melissa A Hass, Evan P Zappulla, David C
Published in
Molecular and cellular biology
The telomerase ribonucleoprotein (RNP) counters the chromosome end replication problem, completing genome replication to prevent cellular senescence in yeast, humans, and most other eukaryotes. The telomerase RNP core enzyme is composed of a dedicated RNA subunit and a reverse transcriptase (telomerase reverse transcriptase [TERT]). Although the ma...
Mefford, Melissa A. Hass, Evan P. Zappulla, David C.
The telomerase ribonucleoprotein (RNP) counters the chromosome end replication problem, completing genome replication to prevent cellular senescence in yeast, humans, and most other eukaryotes. The telomerase RNP core enzyme is composed of a dedicated RNA subunit and a reverse transcriptase (telomerase reverse transcriptase [TERT]). Although the ma...
Williams, Erik A. Santagata, Sandro Wakimoto, Hiroaki Shankar, Ganesh M. Barker, Fred G. II Sharaf, Radwa Reddy, Abhinav Spear, Phoebe Alexander, Brian M. Ross, Jeffrey S.
...
Published in
Acta Neuropathologica Communications
BackgroundGenomic studies of high-grade/progressive meningiomas have reported a heterogeneous mutation spectrum, identifying few recurrently mutated genes. Most studies have been underpowered to detect genomic subclasses of aggressive meningiomas due to relatively small number of available samples. Here, we present a genomic survey of one of the la...
Richardson, Timothy E Kumar, Ashwani Xing, Chao Hatanpaa, Kimmo J Walker, Jamie M
Published in
Journal of neuropathology and experimental neurology
For over a century, gliomas were characterized solely by histologic features. With the publication of the WHO Classification of Tumours of the Central Nervous System, Revised 4th Edition in 2016, integrated histologic and molecular diagnosis became the norm, providing improved tumor grading and prognosis with IDH1/2 (isocitrate dehydrogenase 1 and ...
