Ozawa, Tatsuhiko Kobayashi, Eiji Hamana, Hiroshi Nakamura, Tomoko Lyu, Fulian Hayashi, Atsushi Muraguchi, Atsushi Kishi, Hiroyuki
Published in
European journal of immunology
Generation of TCR-like monoclonal antibodies using conventional methods is markedly laborious and inefficient. We have proposed improvements of ISAAC (chip-based Ab-secreting cell [ASC] screening method), allows comprehensive analysis of ASCs at the single-cell level to obtain TCR-like antibodies; blocking procedure enables us to avoid the detectio...
Naidus, Elliot Bouquet, Jerome Oh, David Y Looney, Timothy J Yang, Hai Fong, Lawrence Standifer, Nathan E Zhang, Li
Published in
Cancer immunology, immunotherapy : CII
Immune checkpoint inhibitors (ICI) are designed to activate exhausted tumor-reactive T cells thereby leading to tumor regression. Durvalumab, an ICI that binds to the programmed death ligand-1 (PD-L1) molecule, is approved as a consolidation therapy for treatment of patients with stage III, unresectable, non-small cell lung cancer (NSCLC). Immunoph...
Xu, Yu Ma, Junwei Luo, Haorui Shi, Yaohuang Liu, Haifeng Sun, Ao Xu, Chenqi Ji, Hongbin Liu, Xiaolong
Published in
European journal of immunology
CD4+ CD8+ double-positive thymocytes give rise to both conventional TCRαβ+ T cells and invariant natural killer T cells (iNKT cells), but these two kinds of cells display different characteristics. The molecular mechanism underlying iNKT cell lineage development and function acquisition remain to be elucidated. We show that the loss of chromatin as...
Bechara, Rami Feray, Alexia Pallardy, Marc
Published in
Frontiers in Immunology
Allergic reactions to drugs and chemicals are mediated by an adaptive immune response involving specific T cells. During thymic selection, T cells that have not yet encountered their cognate antigen are considered naive T cells. Due to the artificial nature of drug/chemical-T-cell epitopes, it is not clear whether thymic selection of drug/chemical-...
Hu, Chao Shen, Meiying Han, Xiaojian Chen, Qian Li, Luo Chen, Siyin Zhang, Jing Gao, Fengxia Wang, Wang Wang, Yingming
...
Published in
Genes & Diseases
Despite the growing knowledge of T cell responses in COVID-19 patients, there is a lack of detailed characterizations for T cell-antigen interactions and T cell functions. Here, with a predicted peptide library from SARS-CoV-2 S and N proteins, restricted to three of the most prominent HLA-A alleles in the Asian population, we found that specific C...
Pertseva, Margarita Gao, Beichen Neumeier, Daniel Yermanos, Alexander Reddy, Sai T.
Adaptive immunity is mediated by lymphocyte B and T cells, which respectively express a vast and diverse repertoire of B cell and T cell receptors and, in conjunction with peptide antigen presentation through major histocompatibility complexes (MHCs), can recognize and respond to pathogens and diseased cells. In recent years, advances in deep seque...
Peled, Michael Adam, Kieran Mor, Adam
Published in
Data in Brief
Therapeutic programmed cell death protein 1 (PD-1) blockade enhances T cell mediated anti-tumor immunity, but many patients do not respond, and a significant proportion develops inflammatory toxicities. To develop better therapeutics and to understand the signaling pathways downstream of PD-1 we performed phosphoproteomic interrogation of PD-1 to i...
Nakayama, Masafumi Hori, Arisa Toyoura, Saori Yamaguchi, Shin-Ichiro
Published in
Cells
Trogocytosis is an active process whereby plasma membrane proteins are transferred from one cell to the other cell in a cell-cell contact-dependent manner. Since the discovery of the intercellular transfer of major histocompatibility complex (MHC) molecules in the 1970s, trogocytosis of MHC molecules between various immune cells has been frequently...
Nguyen, Thi H.O. Rowntree, Louise C. Petersen, Jan Chua, Brendon Y. Hensen, Luca Kedzierski, Lukasz van de Sandt, Carolien E. Chaurasia, Priyanka Tan, Hyon-Xhi Habel, Jennifer R.
...
Published in
Immunity
Examining unmanipulated SARS-CoV-2-specific T cells is important for understanding primary and recall responses during COVID-19. Nguyen et al. analyze ex vivo CD8+ T cells specific for SARS-CoV-2 epitopes and find that immunodominant B7/N105-specific CD8+ T cells are present at high frequencies in blood samples from unexposed, acute COVID-19, and c...
Aguado, Enrique Compeer, Ewoud B. Miazek, Arkadiusz
Published in
Frontiers in Cell and Developmental Biology
