Tasker, Carley Patel, Jenny Jawa, Vibha Maamary, Jad
Published in
The AAPS Journal
Accurate assessment of antigen-specific immune responses is critical in the development of safe and efficacious biotherapeutics and vaccines. Endosomal processing of a protein antigen followed by presentation on major histocompatibility complex (MHC) class II constitute necessary steps in the induction of CD4+ T cell immune responses. Current precl...
Kamb, Alexander Go, William Y.
Published in
F1000Research
T-cell cancer therapy is a clinical field flush with opportunity. It is part of the revolution in immuno-oncology, most apparent in the dramatic clinical success of PD-1/CTLA-4 antibodies and chimeric antigen receptor T-cells (CAR-Ts) to cure certain melanomas and lymphomas, respectively. Therapeutics based on T cells ultimately hold more promise...
Yiu, Hao H Schoettle, Louis N Garcia-Neuer, Marlene Blattman, Joseph N Johnson, Philip L F
Published in
Immunology
Within each individual, the adaptive immune system generates a repertoire of cells expressing receptors capable of recognizing diverse potential pathogens. The theoretical diversity of the T-cell receptor (TCR) repertoire exceeds the actual size of the T-cell population in an individual by several orders of magnitude - making the observation of ide...
Blanchard, Aaron Salaita, Khalid
Published in
Physical biology
Cells use protein-based mechanosensors to measure the physical properties of their surroundings. Synthetic tension sensors made of proteins, DNA, and other molecular building blocks have recently emerged as tools to visualize and perterb the mechanics of these mechanosensors. While almost all synthetic tension sensors are designed to exhibit orient...
He, Shuai Wang, Lin-He Liu, Yang Li, Yi-Qi Chen, Hai-Tian Xu, Jing-Hong Peng, Wan Lin, Guo-Wang Wei, Pan-Pan Li, Bo
...
Published in
Genome Biology
BackgroundAs core units of organ tissues, cells of various types play their harmonious rhythms to maintain the homeostasis of the human body. It is essential to identify the characteristics of cells in human organs and their regulatory networks for understanding the biological mechanisms related to health and disease. However, a systematic and comp...
Yang, Letitia Jama, Burhan Wang, Huawei Labarta-Bajo, Lara Zúñiga, Elina I Morris, Gerald P
Published in
Proceedings of the National Academy of Sciences of the United States of America
It is known that a subpopulation of T cells expresses two T cell receptor (TCR) clonotypes, though the extent and functional significance of this is not established. To definitively evaluate dual TCRα cells, we generated mice with green fluorescent protein and red fluorescent protein reporters linked to TCRα, revealing that ∼16% of T cells express ...
Clohosey, Matthew L. Mann, Brendan T. Ryan, Paul L. Apanasovich, Tatiyana V. Maggirwar, Sanjay B. Pennington, Daniel J. Soriano-Sarabia, Natalia
Published in
Cells
Crosstalk between innate and adaptive pathways is a critical component to developing an effective, lasting immune response. Among natural effector cells, innate-like γδ T cells promote immunity by facilitating communication between the two compartments and exerting cytotoxic effector functions. Dysregulation of γδ T cell populations is a byproduct ...
Odales, Josué Guzman Valle, Jesus Martínez-Cortés, Fernando Manoutcharian, Karen
Published in
Cellular immunology
Antibodies, T cell receptors and major histocompatibility complex molecules are members of the immunoglobulin superfamily and have pivotal roles in the immune system. The fine interrelation between them regulates several immune functions. Here, we describe lesser-known functions ascribed to these molecules in generating and maintaining immune respo...
Lay, Lindsay Stroup, Brooke Payton, Jacqueline E.
Published in
Practical Laboratory Medicine
Cancers of B and T lymphocytes are the most common hematologic malignancies in the US. Molecular assays for assessing clonal rearrangements of the immunoglobulin receptor (IGH) and T-cell receptor (TCR), commonly referred to as B- and T-cell clonality, as well as determination of IGH somatic mutation status, enables improved diagnostic accuracy and...
Smith, Natasha L. Nahrendorf, Wiebke Sutherland, Catherine Mooney, Jason P. Thompson, Joanne Spence, Philip J. Cowan, Graeme J. M.
Published in
Frontiers in Immunology
CD4+ αβ T-cells are key mediators of the immune response to a first Plasmodium infection, undergoing extensive activation and splenic expansion during the acute phase of an infection. However, the clonality and clonal composition of this expansion has not previously been described. Using a comparative infection model, we sequenced the splenic CD4+ ...
