Bliss, Alex Ahmun, Rob Jowitt, Hannah Scott, Phil Jones, Thomas W Tallent, Jamie
Published in
Journal of science and medicine in sport
To quantify and compare the match demands and variability of international One-Day (ODI) with Twenty20 (T20) cricket matches and to compare ODI match demands when competing home and away. Single cohort, longitudinal observation. Thirteen international male seam bowlers across 204matches (ODI=160; T20=44) were investigated over five-years (2015-2019...
BUCHOUD, Nicolas DOUGLAS, Ross Gastineau, Pascal Koning, Martin Mangin, David POINSOT, Philippe SILVAIN, Jean-François Soubelet, Hélène
This Think20 (T20) policy brief is a response to the call to recouple economic growth and social progress, at the dawn of a global infrastructure tsunami. It highlights the lack of a definitive model of urban, metropolitan sustainability and research on its impacts for global infrastructure and multilevel governance needs. It emphasizes that while ...
EVANS, Caroline Godart, Bruno KRIEGER, Jürgen KOVARIK, Jean-Bernard Mimram, Marc Palhol, Fabien
The need to provide resilient transport infrastructure systems is fundamental to enhancing the economic, social, and environmental viability of our cities. In addition to population growth, rapid urbanization, and aging infrastructure, cities increasingly face complex challenges due to the heightened frequency and intensity of natural hazards and t...
Smith, Michele Hoffman, Jonathon Sojar, Hakimuddin Aalinkeel, Ravikumar Hsiao, Chiu-Bin Hicar, Mark Daniel
Published in
Current HIV research
During HIV infection, fusion of the viral and cellular membranes is dependent on folding of the gp41 trimer into a six-helix bundle. Fusion inhibitors, such as the antiretroviral Enfuvirtide (T20), interfere with the formation of the gp41 six-helix bundle. Recent in vitro studies reveal that the gp41 immunodominant region one targeting antibody 3D6...
Zhu, Yuanmei Zhang, Xiujuan Ding, Xiaohui Chong, Huihui Cui, Sheng He, Jinsheng Wang, Xinquan He, Yuxian
Published in
The Journal of Biological Chemistry
Enfuvirtide (T20) is the only viral fusion inhibitor approved for clinical use, but it has relatively weak anti-HIV activity and easily induces drug resistance. In succession to T20, T1249 has been designed as a 39-mer peptide composed of amino acid sequences derived from HIV-1, HIV-2, and simian immunodeficiency virus (SIV); however, its developme...
Benson, Alexis
Klassrumsakustik behandlar rumsliga förutsättningar för ljudutbredning där god talhörbarhet är av vikt för elevers och lärares välbefinnande och möjligheter till goda lärmiljöer. Även kognitiva förmågor som minnesfunktioner påverkas av ljudmiljöer, där lägre bakgrundsljudnivåer och kortare efterklangstider förordas av forskning och byggnadstekniska...
Ding, Xiaohui Zhang, Xiujuan Chong, Huihui Zhu, Yuanmei Wei, Huamian Wu, Xiyuan He, Jinsheng Wang, Xinquan He, Yuxian
Published in
Journal of virology
The peptide drug enfuvirtide (T20) is the only viral fusion inhibitor used in combination therapy for HIV-1 infection, but it has relatively low antiviral activity and easily induces drug resistance. Emerging studies demonstrate that lipopeptide-based fusion inhibitors, such as LP-11 and LP-19, which mainly target the gp41 pocket site, have greatly...
allen, william j. rizzo, robert c.
Virus-cell fusion is the primary means by which the human immunodeficiency virus-1 (HIV) delivers its genetic material into the human T-cell host. Fusion is mediated in large part by the viral glycoprotein 41 (gp41) which advances through four distinct conformational states: (i) native, (ii) pre-hairpin intermediate, (iii) fusion active (fusogenic)...
Azevedo, Rafael Gonçalves de
BV UNIFESP: Teses e dissertações
Veiga, Salomé Yuan, Yunyun Li, Xuqin Santos, Nuno C Liu, Gang Castanho, Miguel A R B
Published in
Biochimica et biophysica acta
The envelope spike (S) glycoprotein of the severe acute respiratory syndrome associated coronavirus (SARS-CoV) mediates the entry of the virus into target cells. Recent studies point out to a cell entry mechanism of this virus similar to other enveloped viruses, such as HIV-1. As it happens with other viruses peptidic fusion inhibitors, SARS-CoV S ...
