Grotegut, Pia Hoerdemann, Philipp Johannes Reinehr, Sabrina Gupta, Nupur Dick, H Burkhard Joachim, Stephanie C
Published in
International journal of molecular sciences
Heat shock protein 27 (HSP27) is one of the small molecular chaperones and is involved in many cell mechanisms. Besides the known protective and helpful functions of intracellular HSP27, very little is known about the mode of action of extracellular HSP27. In a previous study, we showed that intravitreal injection of HSP27 led to neuronal damage in...
Ghosh, Srijit Das, Srijita Mondal, Rupsa Abdullah, Salik Sultana, Shirin Singh, Sukhbir Sehgal, Aayush Behl, Tapan
Published in
International immunopharmacology
COVID-19 is considered the most critical health pandemic of 21st century. Due to extremely high transmission rate, people are more susceptible to viral infection. COVID-19 patients having chronic type-2 asthma prevails a major risk as it may aggravate the disease and morbidities. The present review mainly focuses on correlating the influence of COV...
Deva, Anand K. Turner, Suzanne D. Kadin, Marshall E. Magnusson, Mark R. Prince, H. Miles Miranda, Roberto N. Inghirami, Giorgio G. Adams, William P.
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a CD30-positive, anaplastic lymphoma kinase-negative T-cell lymphoma. Where implant history is known, all confirmed cases to date have occurred in patients with exposure to textured implants. There is a spectrum of disease presentation, with the most common occurring as a seroma...
Krishnamoorthy, Mithunah Lenehan, John G Burton, Jeremy P Maleki Vareki, Saman
Published in
Cancers
Pancreatic cancer has a high mortality rate, and its incidence is increasing worldwide. The almost universal poor prognosis of pancreatic cancer is partly due to symptoms presenting only at late stages and limited effective treatments. Recently, immune checkpoint blockade inhibitors have drastically improved patient survival in metastatic and advan...
Zhou, Emily-Rose Arce, Sergio
Published in
International Journal of Molecular Sciences
Sarcoidosis is a systemic inflammatory disease characterized by development of granulomas in the affected organs. Sarcoidosis is often a diagnosis of exclusion, and traditionally used tests for sarcoidosis demonstrate low sensitivity and specificity. We propose that accuracy of diagnosis can be improved if biomarkers of altered lymphocyte populatio...
Huber, Magdalena Brehm, Corinna U. Gress, Thomas M. Buchholz, Malte Alashkar Alhamwe, Bilal Pogge von Strandmann, Elke Slater, Emily P. Bartsch, Jörg W. Bauer, Christian Lauth, Matthias
...
Published in
International Journal of Molecular Sciences
The biology of solid tumors is strongly determined by the interactions of cancer cells with their surrounding microenvironment. In this regard, pancreatic cancer (pancreatic ductal adenocarcinoma, PDAC) represents a paradigmatic example for the multitude of possible tumor–stroma interactions. PDAC has proven particularly refractory to novel immunot...
Hove-Skovsgaard, Malene Zhao, Yanan Tingstedt, Jeanette Linnea Hartling, Hans Jakob Thudium, Rebekka Faber Benfield, Thomas Afzal, Shoaib Nordestgaard, Børge Ullum, Henrik Gerstoft, Jan
...
Published in
Frontiers in Immunology
Introduction Residual immune dysfunctions, resembling those that occur during normal aging, may persist even in well-treated people with HIV (PWH), and accelerated aging has been proposed. We aimed to determine if HIV infection is an independent risk factor for T-cell immune dysfunctions including increased immune activation, senescence and apoptos...
Johdi, Nor Adzimah Sukor, Nur Fazilah
Published in
Frontiers in Immunology
Colorectal cancer is the third most common cancer in the world with increasing incidence and mortality rates globally. Standard treatments for colorectal cancer have always been surgery, chemotherapy and radiotherapy which may be used in combination to treat patients. However, these treatments have many side effects due to their non-specificity and...
Kalfaoglu, B Almeida-Santos, J Tye, C Yorifumi, S Ono, M
Severe COVID-19 patients show various immunological abnormalities including T-cell reduction and cytokine release syndrome, which can be fatal and is a major concern of the pandemic. However, it is poorly understood how T-cell dysregulation can contribute to the pathogenesis of severe COVID-19. Here we show single cell-level mechanisms for T-cell d...
Thiramanas, Raweewan Li, Mengyi Jiang, Shuai Landfester, Katharina Mailänder, Volker
Published in
Cells
T-cells are a type of lymphocyte (a subtype of white blood cells) that play a central role in cell-mediated immunity. Currently, adoptive T-cell immunotherapy is being developed to destroy cancer cells. In this therapy, T-cells are harvested from a patient’s blood. After several weeks of growth in culture, tumor-specific T-cells can be reinfused in...
