Jones, Christine L. Degasperi, Andrea Grandi, Vieri Amarante, Tauanne D. Ambrose, John C. Arumugam, Prabhu Baple, Emma L. Bleda, Marta Boardman-Pretty, Freya Boissiere, Jeanne M.
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Published in
Scientific Reports
T-cell non-Hodgkin’s lymphomas develop following transformation of tissue resident T-cells. We performed a meta-analysis of whole exome sequencing data from 403 patients with eight subtypes of T-cell non-Hodgkin’s lymphoma to identify mutational signatures and associated recurrent gene mutations. Signature 1, indicative of age-related deamination, ...
Kang, Jin Hyun Lee, Seung Ho Lee, Jawon Choi, Murim Cho, Junhun Kim, Seok Jin Kim, Won Seog Ko, Young Hyeh Yoo, Hae Yong
Published in
BMC Cancer
BackgroundBCOR acts as a corepressor of BCL6, a potent oncogenic protein in cancers of the lymphoid lineage. We have found the recurrent somatic mutation of BCOR occurred in mature T-cell lymphoma (TCL). The role of BCOR mutation in lymphoid malignancies is unknown.MethodsLymphoma patient samples were analyzed to identify missense mutations in BCOR...
Oon, Ming Liang Lim, Jing Quan Lee, Bernett Leong, Sai Mun Soon, Gwyneth Shook-Ting Wong, Zi Wei Lim, Evelyn Huizi Li, Zhenhua Yeoh, Allen Eng Juh Chen, Shangying
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Published in
Cancers
Simple Summary T-cells defend the human body from pathogenic invasion via specific recognition by T-cell receptors (TCRs). The TCR genes undergo recombination (rearrangement) in a myriad of possible ways to generate different TCRs that can recognize a wide diversity of foreign antigens. However, in patients with T-cell lymphoma (TCL), a particular ...
Haddad, Anis Ben Mahmoud, Ahmed Maghrebi, Houcine Chelly, Baya Jouini, Mohamed Kacem, Montasser Jameleddine
Published in
International journal of surgery case reports
T-cell lymphoma degeneration in pancolic crohn's disease is scarce. It is mostly related to long-standing inflammatory bowel disease in patients under immunosuppressants. We reviewed the clinical, endoscopic, radiological and histologic data of the patient as well as the literature dealing with T-cell lymphoma arising from pancolic crohn's disease....
Kohla, Samah Ibrahim, Feryal Bilal, Ilham Al Kuwari, Einas Al-Sabbagh, Ahmad
Published in
Case Reports in Oncology
Gamma-delta (γδ) T-cell lymphomas are very rare and aggressive neoplasms. We describe here a challenging case of γδ T-cell neoplasm composed of γδ mature T-cells and γδ precursor T-cells with marked eosinophilia that is inapplicable to the current 2016 World Health Organization (WHO) classification. A 3-year-old female child who was presented with ...
Uotila, Pyry M Lemma, Siria A Haapasaari, Kirsi-Maria Porvari, Katja Skarp, Sini Soini, Ylermi Jantunen, Esa Turpeenniemi-Hujanen, Taina Kuittinen, Outi
Published in
Hematology (Amsterdam, Netherlands)
ABSTRACT Objectives: To investigate the protein expression of the epithelial-mesenchymal transition-inducing transcription factors (TFs) Twist, ZEB1 and Slug in peripheral T-cell lymphomas (PTCL) and their correlation with clinical parameters. Methods: The expression of these TFs was studied in 53 diagnostic biopsy specimens of several different PT...
Kreutmair, Stefanie Klingeberg, Cathrin Poggio, Teresa Andrieux, Geoffroy Keller, Alexander Miething, Cornelius Follo, Marie Pfeifer, Dietmar Shoumariyeh, Khalid Lengerke, Claudia
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Published in
Leukemia
While cancer stem cells are well established in certain hematologic and solid malignancies, their existence in T cell lymphoma is unclear and the origin of disease is not fully understood. To examine the existence of lymphoma stem cells, we utilized a mouse model of anaplastic large cell lymphoma. Established NPM-ALK+ lymphomas contained heterogene...
Zhang, Meng-Yuan Min, Cong-Cong Fu, Wei-Wei Liu, Hua Yin, Xiao-Yan Zhang, Cui-Ping Tian, Zi-Bin Li, Xiao-Yu
Published in
World Journal of Clinical Cases
BACKGROUND Enteropathy-associated T-cell lymphoma (EATL) is a rare invasive lymphoma derived from gastrointestinal epithelial T lymphocytes. EATL involving the whole gastrointestinal tract accompanied with early colon cancer is extremely rare. CASE SUMMARY We present the case of a 67-year-old man with diarrhea for more than 5 mo whose colonoscopy i...
Sando, Yasuhisa Matsuoka, Ken-Ichi Sumii, Yuichi Kondo, Takumi Ikegawa, Shuntaro Sugiura, Hiroyuki Nakamura, Makoto Iwamoto, Miki Meguri, Yusuke Asada, Noboru
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Photodynamic therapy (PDT) is an emerging treatment for various solid cancers. We recently reported that tumor cell lines and patient specimens from adult T cell leukemia/lymphoma (ATL) are susceptible to specific cell death by visible light exposure after a short-term culture with 5-aminolevulinic acid, indicating that extracorporeal photopheresis...
Sando, Yasuhisa Matsuoka, Ken-ichi Sumii, Yuichi Kondo, Takumi Ikegawa, Shuntaro Sugiura, Hiroyuki Nakamura, Makoto Iwamoto, Miki Meguri, Yusuke Asada, Noboru
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Published in
Scientific Reports
Photodynamic therapy (PDT) is an emerging treatment for various solid cancers. We recently reported that tumor cell lines and patient specimens from adult T cell leukemia/lymphoma (ATL) are susceptible to specific cell death by visible light exposure after a short-term culture with 5-aminolevulinic acid, indicating that extracorporeal photopheresis...
